INT191660

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.15
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GGPS1) small molecule metabolic process (GGPS1) cytoplasm (GGPS1)
Anatomy Link Frequency
Caov-3 1
GGPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 3 86.36 High High
Inflammation 54 50.00 Quite Low
metalloproteinase 2 31.00 Quite Low
cytokine 27 5.00 Very Low Very Low Very Low
Arthritis 10 5.00 Very Low Very Low Very Low
Inflammatory response 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Inflammatory marker 3 5.00 Very Low Very Low Very Low
tolerance 3 5.00 Very Low Very Low Very Low
chemokine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 14 96.40 Very High Very High Very High
Prostate Cancer 6 57.00 Quite High
INFLAMMATION 68 50.00 Quite Low
Aging 21 50.00 Quite Low
Atherosclerosis 44 5.00 Very Low Very Low Very Low
Osteoporosis 35 5.00 Very Low Very Low Very Low
Diabetes Mellitus 33 5.00 Very Low Very Low Very Low
Cancer 20 5.00 Very Low Very Low Very Low
Cardiovascular Disease 20 5.00 Very Low Very Low Very Low
Disease 19 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of FPP synthase prevents the formation of FPP and its derivative GGPP.
Positive_regulation (derivative) of GGPP
1) Confidence 0.05 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0 Pain Relevance 0.08
In alendronate-treated Caov-3 cells, Sawada et al. showed inhibition of Rho activation through GGPP depletion and suggested that this inhibition accounted for the inhibition of LPA-induced stress fiber formation they observed.
Positive_regulation (activation) of GGPP in Caov-3 associated with stress
2) Confidence 0.03 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.15 Pain Relevance 0

General Comments

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