INT191661

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 0.73
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GGPS1) small molecule metabolic process (GGPS1) cytoplasm (GGPS1)
Anatomy Link Frequency
Caov-3 1
GGPS1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 5 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 55 96.80 Very High Very High Very High
Prostate Cancer 25 78.84 Quite High
Apoptosis 15 5.00 Very Low Very Low Very Low
Hypercalcemia 10 5.00 Very Low Very Low Very Low
Cancer 10 5.00 Very Low Very Low Very Low
Pain 5 5.00 Very Low Very Low Very Low
Breast Cancer 5 5.00 Very Low Very Low Very Low
Ovarian Cancer 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
So, inhibition of geranyl-geranylation by ZOL appears to result from a blockade in GGPP synthesis from FPP rather than from the inhibition of the enzymatic transfer of GGPP onto its protein substrate.


Gene_expression (transfer) of GGPP
1) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.29 Pain Relevance 0
In alendronate-treated Caov-3 cells, Sawada et al. showed inhibition of Rho activation through GGPP depletion and suggested that this inhibition accounted for the inhibition of LPA-induced stress fiber formation they observed.
Gene_expression (depletion) of GGPP in Caov-3 associated with stress
2) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.15 Pain Relevance 0
So, inhibition of geranyl-geranylation by ZOL appears to result from a blockade in GGPP synthesis from FPP rather than from the inhibition of the enzymatic transfer of GGPP onto its protein substrate.


Gene_expression (synthesis) of GGPP
3) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.22 Pain Relevance 0
Indeed, some studies support the inhibition of FPP synthase, impairing FPP, and consequently GGPP, production [7-9,15,17], whereas other teams suggest the existence of an additional enzymatic target of N-BPs, downstream of FPP synthase [11,12,34].
Gene_expression (production) of GGPP
4) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0.08 Pain Relevance 0
ZOL impairs Rap1A geranyl-geranylation by preventing GGPP production and not GGPP incorporation into the protein
Gene_expression (production) of GGPP
5) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434759 Disease Relevance 0 Pain Relevance 0

General Comments

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