INT191667

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Context Info
Confidence 0.68
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 4.59
Pain Relevance 3.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sgk1) endoplasmic reticulum (Sgk1) plasma membrane (Sgk1)
nucleus (Sgk1) kinase activity (Sgk1) response to stress (Sgk1)
Anatomy Link Frequency
ventral 1
Sgk1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 380 99.98 Very High Very High Very High
Nucleus accumbens 12 99.82 Very High Very High Very High
dexamethasone 218 99.20 Very High Very High Very High
Locus ceruleus 2 99.20 Very High Very High Very High
withdrawal 18 93.44 High High
Hippocampus 6 86.72 High High
antagonist 28 84.68 Quite High
drug abuse 2 76.64 Quite High
alcohol 2 76.04 Quite High
Pain 3 65.16 Quite High
Disease Link Frequency Relevance Heat
Pancreatic Cancer 123 100.00 Very High Very High Very High
Apoptosis 126 98.08 Very High Very High Very High
Breast Cancer 21 96.20 Very High Very High Very High
Lymphatic System Cancer 6 87.64 High High
Skin Cancer 8 86.60 High High
Metastasis 3 83.80 Quite High
Solid Tumor 15 79.84 Quite High
Drug Dependence 30 76.64 Quite High
Sprains And Strains 164 73.44 Quite High
Vomiting 12 69.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
More specifically, activation of Tsc22d3 in the striatum was limited to the medio-ventral region (nucleus accumbens), while Sgk1 was induced ubiquitously in the whole striatum (Figure 5a).
Positive_regulation (induced) of Sgk1 in ventral associated with nucleus accumbens
1) Confidence 0.68 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.45
The morphine-induced increase in Sgk1 abundance was associated with a significant decrease in the level of the protein (0.75-fold).
Positive_regulation (increase) of Sgk1 associated with morphine
2) Confidence 0.68 Published 2010 Journal Genome Biol Section Body Doc Link PMC2898085 Disease Relevance 0 Pain Relevance 0.42
Moreover, acute morphine induction of two other genes, namely Sgk and Fzd2, also decreased toward the control level after blockade of GR receptor (20 mg/kg RU486; data not shown).
Positive_regulation (induction) of Sgk associated with morphine
3) Confidence 0.61 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.11 Pain Relevance 1.07
Furthermore, alterations in expression of Sgk and Nfkbia were also observed after acute administration of ethanol [43-45].
Positive_regulation (alterations) of Sgk
4) Confidence 0.44 Published 2007 Journal Genome Biol Section Body Doc Link PMC2394777 Disease Relevance 0.22 Pain Relevance 0.75
For inhibition of apoptosis a functional glucocorticoid receptor (GR) is required and association with the transcriptional induction of survival molecules like serum and GC-inducible protein kinase-1 (SGK-1) and mitogen-activated protein kinase phosphatase-1 (MKP-1) is suggested in human established breast cancer cell lines [15].
Positive_regulation (inducible) of SGK-1 associated with breast cancer and apoptosis
5) Confidence 0.30 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.74 Pain Relevance 0.25
For inhibition of apoptosis a functional glucocorticoid receptor (GR) is required and association with the transcriptional induction of survival molecules like serum and GC-inducible protein kinase-1 (SGK-1) and mitogen-activated protein kinase phosphatase-1 (MKP-1) is suggested in human established breast cancer cell lines [15].
Positive_regulation (induction) of SGK-1 associated with breast cancer and apoptosis
6) Confidence 0.30 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.77 Pain Relevance 0.26
During a time kinetic from 24 to 72 h, DEX strongly enhanced the levels of MKP-1, SGK1 and X-IAP, in several pancreatic cancer cell lines examined, while Bcl-2 expression was only marginally increased.
Positive_regulation (increased) of SGK1 associated with pancreatic cancer and dexamethasone
7) Confidence 0.13 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.76 Pain Relevance 0.24

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