INT191669

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Context Info
Confidence 0.26
First Reported 2006
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.35
Pain Relevance 3.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophage 1
Igh-Dex (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 360 100.00 Very High Very High Very High
Inflammation 105 100.00 Very High Very High Very High
withdrawal 5 100.00 Very High Very High Very High
Multiple sclerosis 18 98.28 Very High Very High Very High
cytokine 12 96.52 Very High Very High Very High
Inflammatory mediators 3 95.20 Very High Very High Very High
agonist 3 59.36 Quite High
corticosteroid 5 50.00 Quite Low
metalloproteinase 1 33.84 Quite Low
imagery 4 21.24 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 114 100.00 Very High Very High Very High
Apoptosis 190 99.88 Very High Very High Very High
Cancer 136 99.56 Very High Very High Very High
Multiple Sclerosis 50 98.28 Very High Very High Very High
Pancreatic Cancer 82 86.08 High High
Obesity 12 77.76 Quite High
Hypersensitivity 8 76.08 Quite High
Disease 47 62.60 Quite High
Shock 8 59.88 Quite High
Foreign Bodies 4 51.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Confirmation of copolymer-mediated Dox incorporation and release from polymer–Dex–Dox was also performed using RAW 264.7 macrophage cells.
Localization (release) of Dex in macrophage associated with dexamethasone
1) Confidence 0.26 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636579 Disease Relevance 0.70 Pain Relevance 0.65
In this study, a dual-therapeutic eluting polymer-hybrid film was constructed that releases functional anti-inflammatory (Dex) and anti-cancer drugs (Dox).
Localization (releases) of Dex associated with inflammation, cancer and dexamethasone
2) Confidence 0.23 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636579 Disease Relevance 0.71 Pain Relevance 0.26
Dex incorporation and release from the deposited polymer–Dex–Dox thin films was monitored via the inflammation of cells grown on the polymer–Dex–Dox films with LPS followed by quantitative RT-PCR trials to examine the Dex-mediated suppression of IL-6 and TNF?
Localization (release) of Dex associated with inflammation and dexamethasone
3) Confidence 0.23 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636579 Disease Relevance 0.32 Pain Relevance 0.63
Dex incorporation and release from the deposited polymer–Dex–Dox thin films was monitored via the inflammation of cells grown on the polymer–Dex–Dox films with LPS followed by quantitative RT-PCR trials to examine the Dex-mediated suppression of IL-6 and TNF?
Localization (release) of Dex associated with inflammation and dexamethasone
4) Confidence 0.23 Published 2008 Journal International Journal of Nanomedicine Section Body Doc Link PMC2636579 Disease Relevance 0.32 Pain Relevance 0.63
M DEX as calculated from the means of data obtained with three concentrations of cytotoxic therapy at 24, 48 and 72 h after treatment (Table 2, 3).
Localization (calculated) of DEX associated with dexamethasone
5) Confidence 0.09 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.37 Pain Relevance 0.45
While cytotoxic drugs alone strongly induced apoptosis, the presence of DEX inhibited this effect in all cell lines examined (Fig. 1A, 2A).
Localization (presence) of DEX associated with apoptosis and dexamethasone
6) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.96 Pain Relevance 0.24
6 M Dex as well as 10?
Localization (well) of Dex associated with dexamethasone
7) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2781169 Disease Relevance 0.78 Pain Relevance 0.40
However, withdrawal of both Dex and AIM caused a reduction of ApoE output over 2 weeks.
Localization (withdrawal) of Dex associated with dexamethasone and withdrawal
8) Confidence 0.01 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2596794 Disease Relevance 0.20 Pain Relevance 0.29

General Comments

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