INT191671

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Context Info
Confidence 0.67
First Reported 2006
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 4.63
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap)
protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)
Anatomy Link Frequency
cleavage 1
Xiap (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 144 99.02 Very High Very High Very High
Chronic pancreatitis 2 91.84 High High
corticosteroid 2 50.00 Quite Low
Inflammation 5 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
headache 3 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
alcohol 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatic Cancer 82 100.00 Very High Very High Very High
Melanoma 221 99.54 Very High Very High Very High
Apoptosis 271 97.30 Very High Very High Very High
Ovarian Cancer 30 95.40 Very High Very High Very High
Pancreatitis 2 91.84 High High
Nevus 66 90.56 High High
Breast Cancer 17 88.40 High High
Infection 26 86.36 High High
Cancer 172 86.16 High High
Targeted Disruption 8 71.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, there was no induction of BIRC4/XIAP.
Neg (no) Positive_regulation (induction) of XIAP
1) Confidence 0.67 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.51 Pain Relevance 0
We showed that in our Carboplatin resistant cells, caspase-3 (the main effector caspase) was not activated by Carboplatin alone, yet pre-treatment of YUMAC cells with Phenoxodiol for 2 or 4 hours resulted in decreased levels of XIAP, sensitization to Carboplatin, and remarkable activation of caspase-3.
Positive_regulation (activation) of XIAP
2) Confidence 0.46 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.67 Pain Relevance 0
The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization

XIAP up-regulation is associated with chemotherapy resistance.

Positive_regulation (regulation) of XIAP in cleavage associated with melanoma and apoptosis
3) Confidence 0.43 Published 2007 Journal J Transl Med Section Title Doc Link PMC1796544 Disease Relevance 1.03 Pain Relevance 0
Further studies are needed to determine whether isoflavone analogues and direct XIAP targeting therapies can be used as chemotherapy sensitizers in melanoma patients, and whether XIAP expression levels are associated with response to therapy.



Spec (whether) Positive_regulation (associated) of XIAP associated with melanoma
4) Confidence 0.43 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.64 Pain Relevance 0
Similarly, Bcl-2 overexpression has been associated with acquired resistance of pancreatic carcinoma [32] corresponding to our data which show upregulation X-IAP and to a somehow weaker extent of Bcl-2 in response to DEX.
Positive_regulation (upregulation) of X-IAP associated with pancreatic cancer and dexamethasone
5) Confidence 0.11 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.02 Pain Relevance 0.25
During a time kinetic from 24 to 72 h, DEX strongly enhanced the levels of MKP-1, SGK1 and X-IAP, in several pancreatic cancer cell lines examined, while Bcl-2 expression was only marginally increased.
Positive_regulation (increased) of X-IAP associated with pancreatic cancer and dexamethasone
6) Confidence 0.08 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.76 Pain Relevance 0.24

General Comments

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