INT191678

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Context Info
Confidence 0.71
First Reported 2006
Last Reported 2011
Negated 1
Speculated 1
Reported most in Body
Documents 60
Total Number 64
Disease Relevance 57.25
Pain Relevance 1.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Xiap) nucleus (Xiap) intracellular (Xiap)
protein complex (Xiap) ligase activity (Xiap) cytoplasm (Xiap)
Anatomy Link Frequency
chondrocytes 3
melanocytes 3
cleavage 1
nucleus 1
lung 1
Xiap (Mus musculus)
Pain Link Frequency Relevance Heat
dexamethasone 288 99.54 Very High Very High Very High
cINOD 22 88.32 High High
headache 48 83.04 Quite High
depression 50 80.56 Quite High
palliative 8 69.76 Quite High
tolerance 2 68.48 Quite High
Inflammation 18 55.52 Quite High
cytokine 18 52.24 Quite High
corticosteroid 4 50.00 Quite Low
addiction 2 36.40 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 1518 100.00 Very High Very High Very High
Cancer 2324 99.96 Very High Very High Very High
Nevus 1056 99.88 Very High Very High Very High
Chondrosarcoma 208 99.86 Very High Very High Very High
Melanoma 3508 99.84 Very High Very High Very High
Malignant Neoplastic Disease 526 99.84 Very High Very High Very High
Death 224 99.74 Very High Very High Very High
Pancreatic Cancer 288 99.48 Very High Very High Very High
Ovarian Cancer 480 99.24 Very High Very High Very High
Toxicity 160 98.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased expression of XIAP has been shown to be associated with aggressive malignant behavior and disease progression in a number of malignancies, including lymphoma, breast cancer, lung cancer and renal cell carcinoma [18,25-27].
Gene_expression (expression) of XIAP in lung associated with malignant neoplastic disease, lung cancer, lymphatic system cancer, renal cancer, breast cancer and disease progression
1) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.29 Pain Relevance 0
The purpose of the present work was to assess the expression patterns of XIAP in a large cohort of melanoma tumors and benign nevi, and to assess the association of expression with disease stage.
Gene_expression (expression) of XIAP associated with cancer, melanoma, nevus and disease
2) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.32 Pain Relevance 0.11
Phenoxodiol inhibition of XIAP expression in melanoma cells
Gene_expression (expression) of XIAP associated with melanoma
3) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.82 Pain Relevance 0
In our large cohort of melanomas and nevi we show significantly higher expression in tumors than in nevi, and XIAP expression was significantly higher in metastatic specimens than in primary melanomas.
Gene_expression (expression) of XIAP associated with cancer, melanoma and nevus
4) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.17 Pain Relevance 0
XIAP expression in human tumors
Gene_expression (expression) of XIAP associated with cancer
5) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.60 Pain Relevance 0
Among primary tumors we found an association between high XIAP expression and deep lesions (>2 mm).
Gene_expression (expression) of XIAP associated with cancer
6) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.17 Pain Relevance 0
XIAP expression in a panel of human cell lines
Gene_expression (expression) of XIAP
7) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.86 Pain Relevance 0
XIAP expression was significantly higher in melanomas than nevi (P < 0.0001), and higher in metastatic than primary lesions (P < 0.0001).
Gene_expression (expression) of XIAP associated with melanoma and nevus
8) Confidence 0.71 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC1796544 Disease Relevance 1.04 Pain Relevance 0
While it is unknown whether there is a threshold level above which XIAP inhibitors might be more effective as therapeutics, our data show that there is variability in XIAP expression in melanoma, which should, at the very least, be assessed when XIAP targeting therapies are used in clinical trials in melanoma patients.
Gene_expression (expression) of XIAP associated with melanoma
9) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.90 Pain Relevance 0
Given that these benign nevi were excised, we cannot assess the association between XIAP expression and clinical outcome in nevi.
Gene_expression (expression) of XIAP associated with nevus
10) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.33 Pain Relevance 0
We hypothesize that resistance of melanoma cells to chemotherapy is associated with high baseline expression of XIAP.
Gene_expression (expression) of XIAP associated with melanoma
11) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.30 Pain Relevance 0.12
However, to the best of our knowledge, there are no large cohort studies that thoroughly assess expression levels of XIAP in specimens from patients with melanoma.
Gene_expression (expression) of XIAP associated with melanoma
12) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.28 Pain Relevance 0
Because level of expression may be an important determinant of sensitivity to XIAP targeted therapies, we sought to determine the percent of samples that displayed XIAP over-expression as compared to nevi.
Gene_expression (over) of XIAP associated with nevus
13) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.26 Pain Relevance 0
Moreover, the expression of XIAP was significantly higher in metastatic specimens than in primary specimens (P < 0.0001), as shown in Figure 3.
Gene_expression (expression) of XIAP
14) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.84 Pain Relevance 0
We showed that in our Carboplatin resistant cells, caspase-3 (the main effector caspase) was not activated by Carboplatin alone, yet pre-treatment of YUMAC cells with Phenoxodiol for 2 or 4 hours resulted in decreased levels of XIAP, sensitization to Carboplatin, and remarkable activation of caspase-3.
Gene_expression (levels) of XIAP
15) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.67 Pain Relevance 0
Here we assessed XIAP expression in melanomas, using tissue microarrays containing 436 melanomas and 336 nevi by a novel method of automated, quantitative analysis (AQUA).
Gene_expression (expression) of XIAP associated with melanoma and nevus
16) Confidence 0.71 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC1796544 Disease Relevance 0.92 Pain Relevance 0
We then assessed a panel of melanoma cell lines for XIAP expression, and found high expression in all cell lines.
Gene_expression (expression) of XIAP associated with melanoma
17) Confidence 0.71 Published 2007 Journal J Transl Med Section Abstract Doc Link PMC1796544 Disease Relevance 1.07 Pain Relevance 0
Zhang et al demonstrated up-regulation of XIAP in a limited number of melanoma cell lines [28], and Bowen et al demonstrated higher expression of XIAP in 4 melanoma cell lines than in normal melanocytes, and found an association between XIAP expression and resistance to chemotherapy and radiation therapy [29].
Gene_expression (expression) of XIAP in melanocytes associated with melanoma
18) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 1.30 Pain Relevance 0
Further studies are needed to determine whether isoflavone analogues and direct XIAP targeting therapies can be used as chemotherapy sensitizers in melanoma patients, and whether XIAP expression levels are associated with response to therapy.



Spec (whether) Gene_expression (expression) of XIAP associated with melanoma
19) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.64 Pain Relevance 0
To assess for intra-tumor heterogeneity of XIAP expression in melanoma specimens, we used tissue arrays containing tumor cores from 565 melanoma patients.
Gene_expression (expression) of XIAP associated with melanoma and cancer
20) Confidence 0.71 Published 2007 Journal J Transl Med Section Body Doc Link PMC1796544 Disease Relevance 0.64 Pain Relevance 0

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