INT191686

Context Info Confidence 0.04 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.79 Pain Relevance 0.46

mitochondrion (Sgk1) endoplasmic reticulum (Sgk1) plasma membrane (Sgk1) nucleus (Sgk1) kinase activity (Sgk1) response to stress (Sgk1)

Igh-Dex (Mus musculus) Sgk1 (Mus musculus)

Pain Link Frequency Relevance Heat dexamethasone 144 100.00 Chronic pancreatitis 2 90.32 corticosteroid 2 50.00 palliative 2 5.00 Inflammation 2 5.00 Pain 2 5.00

Disease Link Frequency Relevance Heat Pancreatic Cancer 82 99.08 Apoptosis 72 97.64 Breast Cancer 14 90.48 Pancreatitis 2 90.32 Carcinoma 6 71.08 Death 4 64.16 Lymphatic System Cancer 4 55.32 Skin Cancer 4 54.76 Solid Tumor 10 45.12 Reprotox - General 1 6 44.20

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In contrast, we found DEX-induced upregulation of the pro-survival genes SGK-1 and MKP-1.

DEX Positive_regulation (upregulation) of SGK-1 associated with dexamethasone

1) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 1.16 Pain Relevance 0.22

During a time kinetic from 24 to 72 h, DEX strongly enhanced the levels of MKP-1, SGK1 and X-IAP, in several pancreatic cancer cell lines examined, while Bcl-2 expression was only marginally increased.

DEX Positive_regulation (enhanced) of SGK1 associated with pancreatic cancer and dexamethasone

2) Confidence 0.02 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1434760 Disease Relevance 0.63 Pain Relevance 0.24

General Comments

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