INT191731

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Context Info
Confidence 0.43
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 32
Disease Relevance 14.46
Pain Relevance 0.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
stigma 1
plug 1
skin 1
face 1
Lmrq1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 4 99.28 Very High Very High Very High
Pain 25 79.84 Quite High
Inflammation 33 58.64 Quite High
cytokine 43 58.12 Quite High
abdominal pain 5 53.60 Quite High
agonist 5 50.00 Quite Low
headache 2 50.00 Quite Low
cryotherapy 8 44.56 Quite Low
anesthesia 8 40.80 Quite Low
Bioavailability 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 853 100.00 Very High Very High Very High
Leishmaniasis 1141 99.98 Very High Very High Very High
Sprains And Strains 49 99.84 Very High Very High Very High
Pox Virus Infection 18 99.56 Very High Very High Very High
Disease 317 98.22 Very High Very High Very High
Htlv Types I And Ii 8 97.22 Very High Very High Very High
Diffuse Cutaneous Leishmaniasis 13 95.96 Very High Very High Very High
Cicatrix 42 92.94 High High
Pressure And Volume Under Development 28 92.32 High High
Toxicity 14 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Growth development, determined by weekly body mass measure, was not affected by the Leishmania infection and no expressive alterations of health markers were observed.
Gene_expression (infection) of Leishmania in body associated with infection
1) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2814861 Disease Relevance 0.72 Pain Relevance 0
These data show that whole blood is not a reliable sample to detect Leishmania infection, at least in this mammal host species.
Gene_expression (infection) of Leishmania in blood associated with infection
2) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2814861 Disease Relevance 0.48 Pain Relevance 0
12) obtained from the Oswaldo Cruz Institute Leishmania collection (Coleção de Leishmania do Instituto Oswaldo Cruz, CLIOC).
Gene_expression (collection) of Leishmania
3) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2814861 Disease Relevance 0.32 Pain Relevance 0
12) obtained from the Oswaldo Cruz Institute Leishmania collection (Coleção de Leishmania do Instituto Oswaldo Cruz, CLIOC).
Gene_expression (collection) of Leishmania
4) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2814861 Disease Relevance 0.32 Pain Relevance 0
It was proposed that the entry of new species of Leishmania (Leishmania) subgenus was the consequence of the arrival of infected caviomorph rodents during the Oligocene [17]; 2) the detection of Leishmania sp.
Gene_expression (detection) of Leishmania
5) Confidence 0.43 Published 2010 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2814861 Disease Relevance 0.16 Pain Relevance 0
We describe an elegant and novel example of behavioral manipulation in which the timing of parasite development is linked to the feeding persistence of the sand fly vector and demonstrate that such a strategy enhances Leishmania transmission.


Gene_expression (transmission) of Leishmania
6) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904410 Disease Relevance 0.14 Pain Relevance 0
The combination of these two events results in the blockage of the anterior midgut with a plug of Leishmania promastigotes and their gel, which distends and permanently holds open the already eroded valve.
Gene_expression (promastigotes) of Leishmania in plug
7) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904410 Disease Relevance 0.22 Pain Relevance 0
Further, Leishmania infection specifically causes an increase in vector biting persistence on mice (re-feeding after interruption) and also promotes feeding on multiple hosts.
Gene_expression (infection) of Leishmania associated with infection
8) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Abstract Doc Link PMC1904410 Disease Relevance 0.23 Pain Relevance 0
In this study, we investigate the behavior of Leishmania-infected sand flies.
Gene_expression (flies) of Leishmania-infected
9) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904410 Disease Relevance 0.13 Pain Relevance 0
Leishmania Manipulation of Sand Fly Feeding Behavior Results in Enhanced Transmission

In nature the prevalence of Leishmania infection in whole sand fly populations can be very low (<0.1%), even in areas of endemicity and high transmission.

Gene_expression (infection) of Leishmania associated with infection
10) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Title Doc Link PMC1904410 Disease Relevance 0.17 Pain Relevance 0
This study significantly improves our understanding of Leishmania transmission, and these findings can now be incorporated into both epidemiological and experimental models of infection.


Gene_expression (transmission) of Leishmania associated with infection
11) Confidence 0.38 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904410 Disease Relevance 0.44 Pain Relevance 0
Sand fly infections initiated with tissue-derived amastigotes of both L. mexicana (experimental combination) and Leishmania infantum (natural combination) in Lutzomyia longipalpis were produced, and the generation of metacyclic promastigotes and fPPG synthesis was examined (Figure 1).
Gene_expression (produced) of Leishmania associated with infection
12) Confidence 0.34 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1904410 Disease Relevance 0.10 Pain Relevance 0
Since an increased number of ATL autochthonous cases has been diagnosed in the Northeastern region of the State of São Paulo (SP), it has become important to identify the Leishmania species involved as well as its pathogenecity.1,8 For this proposal, PCR has been utilized with great specificity and sensibility.9–12

MATERIALS AND METHODS

Gene_expression (species) of Leishmania associated with htlv types i and ii
13) Confidence 0.21 Published 2008 Journal Clinics Section Body Doc Link PMC2664119 Disease Relevance 0.39 Pain Relevance 0
Recently, a method of mass screening sand flies for Leishmania infection was established, and its usability for field research confirmed [46,47].
Gene_expression (infection) of Leishmania associated with infection
14) Confidence 0.17 Published 2010 Journal International Journal of Environmental Research and Public Health Section Body Doc Link PMC2872317 Disease Relevance 0.10 Pain Relevance 0
In contrast, Laurent et al [24], used the OC dipstick to detect PCR products of Leishmania but achieved a 10 times lower sensitivity of 14 parasites per ?
Gene_expression (products) of Leishmania
15) Confidence 0.14 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2844367 Disease Relevance 0.54 Pain Relevance 0
In the present study, blood samples of parasitologically confirmed VL patients were used for the detection of Leishmania.
Gene_expression (detection) of Leishmania in blood associated with leishmaniasis
16) Confidence 0.12 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2844367 Disease Relevance 0.60 Pain Relevance 0
In South America, Leishmania amazonensis is one of the causative agents of localized cutaneous leishmaniasis and the most important agent of diffuse cutaneous leishmaniasis (DCL), a devastating disease with uncontrolled progression, characterized by multiple skin lesions and vaste numbers of amastigotes.
Gene_expression (amazonensis) of Leishmania in skin associated with leishmaniasis, diffuse cutaneous leishmaniasis and disease
17) Confidence 0.10 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2398787 Disease Relevance 1.32 Pain Relevance 0
The treatment did not lead to sterile cure of lesions but Leishmania parasites have been shown to remain present and viable, although in decreased numbers, after treatment with antimonials in a variety of animal models, as well as in humans.
Gene_expression (parasites) of Leishmania
18) Confidence 0.10 Published 2008 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2398787 Disease Relevance 0.50 Pain Relevance 0
Secondly, imiquimod could mediate a better anti-Leishmania Th1 immune response that would result in the production of IFN-?
Gene_expression (immune) of Leishmania
19) Confidence 0.10 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2710502 Disease Relevance 0.47 Pain Relevance 0
Also, we know that some drugs and regimens are effective only against certain Leishmania species or strains and only in certain areas of the world.
Gene_expression (species) of Leishmania associated with sprains and strains
20) Confidence 0.07 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2765639 Disease Relevance 0.79 Pain Relevance 0.07

General Comments

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