INT191766

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Context Info
Confidence 0.07
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 3.40
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

IGKV1D-39 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 203 97.26 Very High Very High Very High
imagery 14 95.92 Very High Very High Very High
Arthritis 7 89.36 High High
cytokine 21 89.20 High High
Analgesic 35 85.36 High High
Inflammatory stimuli 14 84.48 Quite High
Eae 14 74.92 Quite High
analgesia 6 37.24 Quite Low
lidocaine 2 29.00 Quite Low
anesthesia 10 25.04 Quite Low
Disease Link Frequency Relevance Heat
Sleep Disorders 98 100.00 Very High Very High Very High
Stress 7 98.04 Very High Very High Very High
INFLAMMATION 245 97.26 Very High Very High Very High
Disease 28 95.48 Very High Very High Very High
Adhesions 287 94.08 High High
Injury 7 92.48 High High
Necrosis 14 91.92 High High
Cancer 14 91.56 High High
Arthritis 7 89.36 High High
Diabetes Mellitus 7 88.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Before N2O/O2 sedation, patients’ RSS were determined as 1 but after the administration of N2O/O2, at the T1-6 time points patients’ RSS were 2 and OAA/S scores of patients’ were 4 or 5.
Negative_regulation (Before) of Gene_expression (sedation) of O2 associated with sleep disorders
1) Confidence 0.07 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.31 Pain Relevance 0
Before N2O/O2 sedation, patients’ RSS were determined as 1 but after the administration of N2O/O2, at the T1-6 time points patients’ RSS were 2 and OAA/S scores of patients’ were 4 or 5.
Negative_regulation (Before) of Gene_expression (sedation) of N2O associated with sleep disorders
2) Confidence 0.07 Published 2007 Journal European journal of dentistry Section Body Doc Link PMC2609910 Disease Relevance 0.31 Pain Relevance 0
In summary, our in vitro results indicate that the in vivo anti-inflammatory properties of compounds NF161 and NF177 [16,17] do not involve the COX pathway, but may be due to their anti-adhesive effects and their inhibition of O2-. production and of myeloperoxidase release, these properties being shown in vitro with steep concentration-response curves and at high concentrations.
Negative_regulation (inhibition) of Gene_expression (production) of O2 associated with inflammation
3) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.43 Pain Relevance 0.12
O2-. production and myeloperoxidase release from PMNs stimulated by FMLP was inhibited in a dose- but not time-dependent manner by both [1,8]naphthyridine derivatives, NF161 being statistically more active than NF177 (P < 0.01).
Negative_regulation (inhibited) of Gene_expression (production) of O2
4) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1435878 Disease Relevance 0.84 Pain Relevance 0.39
NF161 percentage inhibition vs control was 98 ± 1% and its IC50 = 2.1 ± 0.4 × 10-5M; the inhibition of O2-. production induced by NF177 was lower (**p < 0.01: NF161 vs NF177), being 83 ± 4%, and its IC50 = 2.5 ± 0.5 × 105 M.
Negative_regulation (inhibition) of Gene_expression (production) of O2
5) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.06 Pain Relevance 0.03
Even when in cubation time was prolonged (30 min; data not shown), the substances tested were still able to inhibit O2-. production, with a dose-response curve quantitatively and qualitatively equal to those depicted above in Fig. 2. 2-chloroadenosine, a well known modulator of PMN functions, used as positive control [27], caused greater inhibition than the tested compounds, with maximum effect of 70 ± 4% inhibition, and IC50 = 87 ± 6 × 10-9M.
Negative_regulation (inhibit) of Gene_expression (production) of O2
6) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.12 Pain Relevance 0.06
Both compounds dose-dependently inhibited O2-. production evoked by 10-7M FMLP.
Negative_regulation (inhibited) of Gene_expression (production) of O2
7) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.07 Pain Relevance 0.03
The compounds' effects on the production of reactive oxygen species (ROS) by human polymorphonuclear cells (PMNs) were studied in an in vitro cell model, evaluating inhibition of superoxide anion (O2-.) production induced by N-formylmethionyl-leucyl-phenylalanine (FMLP).
Negative_regulation (inhibition) of Gene_expression (production) of O2
8) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Abstract Doc Link PMC1435878 Disease Relevance 0.63 Pain Relevance 0.46
Therefore the ability of these [1,8] naphthyridine derivatives to inhibit O2-. production demonstrates their role in modulating oxidative stress and suggests their potential use in various degenerative diseases.


Negative_regulation (inhibit) of Gene_expression (production) of O2 associated with stress and disease
9) Confidence 0.03 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1435878 Disease Relevance 0.64 Pain Relevance 0.04

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