INT191778

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.76
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (F7) extracellular space (F7) extracellular region (F7)
Anatomy Link Frequency
lung 2
body 2
F7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammatory response 9 94.60 High High
Inflammation 15 72.16 Quite High
tolerance 4 60.04 Quite High
cytokine 16 41.28 Quite Low
ischemia 9 5.00 Very Low Very Low Very Low
fibrosis 8 5.00 Very Low Very Low Very Low
aspirin 4 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 22 96.84 Very High Very High Very High
Hyperinsulinism 7 96.38 Very High Very High Very High
Nicotine Addiction 6 95.96 Very High Very High Very High
Diabetic Cardiomyopathies 105 94.72 High High
INFLAMMATION 24 94.60 High High
Pressure And Volume Under Development 32 91.82 High High
Disorder Of Lipid Metabolism 3 91.44 High High
Hyperlipidemia 4 90.74 High High
Hyperglycemia 13 90.30 High High
Abdominal Obesity 4 90.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The rat fetal distal lung epithelium has been used in vitro to study epithelial thrombin formation and it has been shown, by Chan et al, that lung epithelial cells promote thrombin generation via the expression of factor VII dependent tissue factor activity [41].
Positive_regulation (promote) of Gene_expression (expression) of factor VII in lung
1) Confidence 0.01 Published 2006 Journal Respir Res Section Body Doc Link PMC1435891 Disease Relevance 0.31 Pain Relevance 0.03
Insulin resistance and hyperinsulinemia have been identified as risk factors for DCM.78,79 In hyperinsulinemia and insulin resistance, an imbalance in the direct effects of insulin action occurs, accompanied by the confounding effects of other cardiovascular risk factors associated with the insulin resistance syndrome, ie, central obesity, hyperglycemia, hypertriglyceridemia, low high-density lipoprotein (HDL), and hypertension.80 The clustering of these cardiovascular and atherothrombotic risk factors that accompany insulin resistance provides a plausible basis for DCM and is often associated with adverse cardiovascular effects.81,82 Hyperinsulinemia and insulin resistance are also associated with a cluster of thrombotic risk factors, such as elevated levels of PAI-1,83,84 factor VII, factor XII, and fibrinogen.85–87 Increased levels of factor VII and XII may also occur through activation by triglyceride-rich particles, whereas hyperfibrinogenemia may be attributed to smoking, increased body mass, and inflammatory responses.
Positive_regulation (occur) of Gene_expression (levels) of factor VII in body associated with hyperglycemia, pressure and volume under development, inflammatory response, nicotine addiction, metabolic syndrome, diabetic cardiomyopathies, insulin resistance, abdominal obesity, hyperinsulinism, hyperlipidemia and disorder of lipid metabolism
2) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2964943 Disease Relevance 2.44 Pain Relevance 0.11

General Comments

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