INT191803

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.49
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD24) signal transducer activity (CD24)
Anatomy Link Frequency
endothelial cells 1
lung 1
CD24 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 190 99.80 Very High Very High Very High
palliative 5 56.32 Quite High
Central nervous system 10 5.00 Very Low Very Low Very Low
cytokine 9 5.00 Very Low Very Low Very Low
Bile 8 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Angina 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
COX2 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Prostate Cancer 27 100.00 Very High Very High Very High
Multiple Sclerosis 202 99.80 Very High Very High Very High
Leukemia 3 99.38 Very High Very High Very High
Hypoxia 18 98.80 Very High Very High Very High
Apoptosis 14 98.24 Very High Very High Very High
Benign Prostatic Hypertrophy 13 98.16 Very High Very High Very High
Lung Cancer 3 97.24 Very High Very High Very High
Ovarian Cancer 2 94.00 High High
Recurrence 5 91.48 High High
Autoimmune Disease 50 90.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
They noted several genes transcriptionally upregulated including CD24 at late times of exposure to hypoxia, indicating that it was a useful marker of hypoxic activation in vascular endothelial cells.
Positive_regulation (upregulated) of CD24 in endothelial cells associated with hypoxia
1) Confidence 0.70 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 1.55 Pain Relevance 0.06
Furthermore, correlation between CD24 expression and radiation sensitivity has been noted to vary with the cell type as in human small cell lung cancer, and radiation doses required to induce apoptosis of CD24-negative human ALL (acute lymphoblastic leukemia) cells were higher than those required for CD24-positive cells, suggesting that lack of CD24 surface antigen expression is associated with intrinsic radiation resistance.34,35
Positive_regulation (required) of CD24 in lung associated with leukemia, lung cancer and apoptosis
2) Confidence 0.50 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 1.06 Pain Relevance 0
In summary, results from both of population and the family studies confirm our earlier conclusion that the CD24 locus is a major modulator for MS risk.
Positive_regulation (modulator) of CD24 associated with multiple sclerosis
3) Confidence 0.50 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.89 Pain Relevance 0.33
Thus, the dinucleotide deletion at the P1527 position destabilized CD24 mRNA.


Positive_regulation (destabilized) of CD24
4) Confidence 0.50 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.27 Pain Relevance 0.04
Normalized CD24 transcript levels in 59 Pca cases were increased 2.69-fold on the average when compared to 55 BPH cases.
Positive_regulation (increased) of CD24 associated with benign prostatic hypertrophy and prostate cancer
5) Confidence 0.46 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 1.31 Pain Relevance 0
Compared to isotype controls, USC-HN1 displays significantly increased staining of FABP5, E-cadherin, and CD24.
Positive_regulation (increased) of CD24
6) Confidence 0.19 Published 2010 Journal Head Neck Oncol Section Body Doc Link PMC2841166 Disease Relevance 0.42 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox