INT191804

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Context Info
Confidence 0.72
First Reported 2006
Last Reported 2007
Negated 1
Speculated 1
Reported most in Body
Documents 10
Total Number 18
Disease Relevance 12.43
Pain Relevance 1.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD24) signal transducer activity (CD24)
Anatomy Link Frequency
urine 2
CD24 (Homo sapiens)
Pain Link Frequency Relevance Heat
Multiple sclerosis 855 96.28 Very High Very High Very High
Central nervous system 45 89.92 High High
palliative 27 80.84 Quite High
Angina 9 51.88 Quite High
Pain 9 50.20 Quite High
Inflammation 9 8.28 Low Low
Disease Link Frequency Relevance Heat
Prostate Cancer 243 99.84 Very High Very High Very High
Multiple Sclerosis 909 99.68 Very High Very High Very High
Contagious Ecthyma 9 99.56 Very High Very High Very High
Hepatocellular Cancer 9 99.56 Very High Very High Very High
Lung Cancer 9 99.20 Very High Very High Very High
Cancer 225 97.64 Very High Very High Very High
Ovarian Cancer 18 97.28 Very High Very High Very High
Systemic Lupus Erythematosus 441 97.20 Very High Very High Very High
Benign Prostatic Hypertrophy 117 96.92 Very High Very High Very High
Renal Cancer 9 93.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Prior to actinomycin D treatment, there was significantly higher mRNA expression for the CD24TG cDNA in comparison to the CD24del cDNA.
Transcription (expression) of CD24TG
1) Confidence 0.72 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0 Pain Relevance 0
Since the two alleles were present in the same cells and therefore were transcribed at the same rate, our data demonstrate that the P1527 variant has a strong impact on mRNA expression of CD24 in vivo, most likely by post-transcriptional mechanisms.


Transcription (expression) of CD24
2) Confidence 0.72 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.11 Pain Relevance 0.03
As shown in Figure 4A, the primers designed for the P1527TG allele detected CD24 mRNA in the P1527TG/TG, but not in the P1527del/del individuals, and vice versa.
Neg (not) Transcription (detected) of CD24
3) Confidence 0.72 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.34 Pain Relevance 0.04
Two cis elements of mouse Cd24 mRNA, a negative and a positive cis element, regulate the stability of mouse Cd24 mRNA expression and determine cell-surface CD24 expression [31].
Transcription (expression) of Cd24
4) Confidence 0.72 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.84 Pain Relevance 0.15
Real-time one-step RT-PCR for detecting CD24 mRNA was performed using a LightCycler thermal cycler system according to the manufacturer's instructions (Roche Diagnostics GmbH, Mannheim, Germany).
Transcription (detecting) of CD24
5) Confidence 0.71 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 0.44 Pain Relevance 0.08
The dinucleotide deletion significantly reduced the stability of CD24 mRNA.
Transcription (stability) of CD24
6) Confidence 0.69 Published 2007 Journal PLoS Genetics Section Abstract Doc Link PMC1847692 Disease Relevance 0.99 Pain Relevance 0.18
Human CD24 (CD24) mRNA has a 0.24-kb ORF and a 1.8-kb 3?
Transcription (has) of CD24 associated with contagious ecthyma
7) Confidence 0.69 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 1.28 Pain Relevance 0.22
Human CD24 (CD24) mRNA has a 0.24-kb ORF and a 1.8-kb 3?
Transcription (has) of CD24 associated with contagious ecthyma
8) Confidence 0.69 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 1.34 Pain Relevance 0.27
Two cis elements of mouse Cd24 mRNA, a negative and a positive cis element, regulate the stability of mouse Cd24 mRNA expression and determine cell-surface CD24 expression [31].
Spec (determine) Transcription (elements) of Cd24
9) Confidence 0.69 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.79 Pain Relevance 0.14
The present study demonstrates the feasibility of quantitative CD24 RNA transcript detection in prostatic tissues even without previous laser microdissection.
Transcription (detection) of CD24
10) Confidence 0.68 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 0.93 Pain Relevance 0
Based on the RT-PCR protocol using LightCycler technology, the present study revealed a highly significant elevation of tissue CD24 mRNA expression in Pca patients compared to patients with a benign histology.
Transcription (expression) of CD24 associated with prostate cancer
11) Confidence 0.62 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 0.72 Pain Relevance 0
Fifth, the dinucleotide deletion reduced steady levels of CD24 mRNA by more than 2-fold.
Transcription (levels) of CD24
12) Confidence 0.53 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.75 Pain Relevance 0.14
For each sample, copy numbers of CD24 mRNA were divided by those of PBGD mRNA to normalize for CD24 mRNA expression and thus avoid sample-to-sample differences in RNA quantity.


Transcription (expression) of CD24
13) Confidence 0.53 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 0.05 Pain Relevance 0
Normalized CD24 transcript levels in 59 Pca cases were increased 2.69-fold on the average when compared to 55 BPH cases.
Transcription (levels) of CD24 associated with benign prostatic hypertrophy and prostate cancer
14) Confidence 0.53 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 1.30 Pain Relevance 0
If CD24 mRNA should be detectable not only in tissue but also in prostatic secretions or even urine, the RT-PCR presented here could serve as an important noninvasive supplement to other procedures (digital rectal examination and serum PSA) within the framework of cancer screening.
Transcription (detectable) of CD24 in urine associated with cancer
15) Confidence 0.53 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 0.78 Pain Relevance 0
For each sample, copy numbers of CD24 mRNA were divided by those of PBGD mRNA to normalize for CD24 mRNA expression and thus avoid sample-to-sample differences in RNA quantity.


Transcription (expression) of CD24
16) Confidence 0.53 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 0.05 Pain Relevance 0
If CD24 mRNA should be detectable not only in tissue but also in prostatic secretions or even urine, the RT-PCR presented here could serve as an important noninvasive supplement to other procedures (digital rectal examination and serum PSA) within the framework of cancer screening.


Transcription (detectable) of CD24 in urine associated with cancer
17) Confidence 0.53 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 0.76 Pain Relevance 0
Huang showed that CD24 mRNA is expressed in 66% of hepatocellular carcinomas (HCC) [12].
Transcription (expressed) of CD24 associated with hepatocellular cancer
18) Confidence 0.53 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 0.96 Pain Relevance 0

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