INT191806

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 9.94
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD24) signal transducer activity (CD24)
Anatomy Link Frequency
biliary epithelium 2
lung 2
neural 2
CD24 (Homo sapiens)
Pain Link Frequency Relevance Heat
Bile 40 99.28 Very High Very High Very High
palliative 13 96.36 Very High Very High Very High
Multiple sclerosis 95 92.52 High High
Demyelination 3 89.68 High High
Spinal cord 16 84.16 Quite High
Central nervous system 5 81.48 Quite High
allodynia 9 25.00 Low Low
Peripheral nervous system 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cholangiocarcinoma 190 99.98 Very High Very High Very High
Apoptosis 70 99.88 Very High Very High Very High
Prostate Cancer 27 99.80 Very High Very High Very High
Metastasis 23 99.58 Very High Very High Very High
Benign Prostatic Hypertrophy 13 99.28 Very High Very High Very High
Cancer 313 98.86 Very High Very High Very High
Leukemia 10 98.38 Very High Very High Very High
Lung Cancer 11 96.24 Very High Very High Very High
Disease Progression 14 96.04 Very High Very High Very High
Hypoxia 90 95.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, overexpression of the molecular marker CD24 in cholangiocarcinoma is predictive of poor survival.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD24 associated with cholangiocarcinoma
1) Confidence 0.70 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.77 Pain Relevance 0
Overexpression of CD24 continued to affect survival adversely despite the overall improvement noted with the addition of radiation therapy.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of CD24
2) Confidence 0.70 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.23 Pain Relevance 0.03
Figure 1Moderately differentiated cholangiocarcinoma with overexpression of CD24.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD24 associated with cholangiocarcinoma
3) Confidence 0.70 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.49 Pain Relevance 0.12
Furthermore, correlation between CD24 expression and radiation sensitivity has been noted to vary with the cell type as in human small cell lung cancer, and radiation doses required to induce apoptosis of CD24-negative human ALL (acute lymphoblastic leukemia) cells were higher than those required for CD24-positive cells, suggesting that lack of CD24 surface antigen expression is associated with intrinsic radiation resistance.34,35
Positive_regulation (lack) of Gene_expression (expression) of CD24 in lung associated with leukemia, lung cancer and apoptosis
4) Confidence 0.50 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 1.20 Pain Relevance 0
CD24 overexpressors demonstrated a lack of response to chemotherapy and possibly radiation therapy although these observations were limited by the small sample size.
Positive_regulation (overexpressors) of Gene_expression (overexpressors) of CD24
5) Confidence 0.50 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.71 Pain Relevance 0
This Pca patient population had a 2.69 times higher mean CD24 expression for Pca than for BPH.
Positive_regulation (mean) of Gene_expression (expression) of CD24 associated with benign prostatic hypertrophy and prostate cancer
6) Confidence 0.50 Published 2006 Journal BMC Urol Section Body Doc Link PMC1435920 Disease Relevance 1.04 Pain Relevance 0
This finding that shows that patients with low expression of CD24 may benefit from chemotherapy or radiation is of importance because it has been previously reported that adjuvant or palliative radiation had no effect on survival in patients with cholangiocarcinoma.41 However, the small number of patients in the present series limits interpretation of data suggesting that CD24 overexpression may be predictive of lack of response to radiation or chemotherapy.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD24 associated with cholangiocarcinoma and palliative
7) Confidence 0.47 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.89 Pain Relevance 0.10
Median survival for patients with overexpression of CD24 was significantly shorter, and the addition of chemotherapy improved survival.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD24
8) Confidence 0.47 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.94 Pain Relevance 0
Figure 1 depicts cholangiocarcinoma positive for CD24 expression adjacent to normal biliary epithelium.
Positive_regulation (positive) of Gene_expression (expression) of CD24 in biliary epithelium associated with cholangiocarcinoma
9) Confidence 0.47 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.58 Pain Relevance 0.12
Multivariate analysis using the Cox’s proportional hazards survival analysis demonstrated that overexpression of CD24 (p?
Positive_regulation (overexpression) of Gene_expression (overexpression) of CD24
10) Confidence 0.47 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.21 Pain Relevance 0.03
Biochemical analysis indicated that the deletion leads to rapid decay of CD24 mRNA, which should result in reduced synthesis of the CD24 protein.
Positive_regulation (result) of Gene_expression (synthesis) of CD24
11) Confidence 0.47 Published 2007 Journal PLoS Genetics Section Abstract Doc Link PMC1847692 Disease Relevance 1.22 Pain Relevance 0.24
Additional properties of tumor proliferation, invasion, metastasis, and apoptosis make CD24 a potent target for specifically directed molecular therapy and its overexpression a potential criterion in the selection of patients for the appropriate conventional treatment modality.



Positive_regulation (overexpression) of Gene_expression (overexpression) of CD24 associated with cancer, apoptosis and metastasis
12) Confidence 0.44 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.65 Pain Relevance 0
Human neural stem cells (hCNS-SCns) were prospectively isolated based on fluorescence-activated cell sorting for a CD133+ and CD24?
Positive_regulation (activated) of Gene_expression (cell) of CD24 in neural
13) Confidence 0.22 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923623 Disease Relevance 1.01 Pain Relevance 0.16

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