INT191807

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 75
Total Number 75
Disease Relevance 53.92
Pain Relevance 3.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (CD24) signal transducer activity (CD24)
Anatomy Link Frequency
T cells 4
margins 3
lung 3
platelets 2
endothelial cells 2
CD24 (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 71 99.80 Very High Very High Very High
Multiple sclerosis 1330 99.38 Very High Very High Very High
Bile 164 99.28 Very High Very High Very High
palliative 90 97.76 Very High Very High Very High
Demyelination 4 89.28 High High
Spinal cord 51 84.16 Quite High
Angina 14 61.56 Quite High
Pain 18 59.88 Quite High
allodynia 9 25.00 Low Low
Inflammation 18 17.96 Low Low
Disease Link Frequency Relevance Heat
Solid Tumor 41 100.00 Very High Very High Very High
Cholangiocarcinoma 779 99.88 Very High Very High Very High
Apoptosis 291 99.88 Very High Very High Very High
Cancer 1563 99.80 Very High Very High Very High
Prostate Cancer 432 99.80 Very High Very High Very High
Metastasis 130 99.58 Very High Very High Very High
Heart Rate Under Development 64 99.44 Very High Very High Very High
Multiple Sclerosis 1414 99.38 Very High Very High Very High
Benign Prostatic Hypertrophy 208 99.28 Very High Very High Very High
Disease Progression 99 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Multivariate analysis using the Cox’s proportional hazards survival analysis demonstrated that overexpression of CD24 (p?
Gene_expression (overexpression) of CD24
1) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.21 Pain Relevance 0.03
Figure 1Moderately differentiated cholangiocarcinoma with overexpression of CD24.
Gene_expression (overexpression) of CD24 associated with cholangiocarcinoma
2) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.49 Pain Relevance 0.12
In conclusion, overexpression of the molecular marker CD24 in cholangiocarcinoma is predictive of poor survival.
Gene_expression (overexpression) of CD24 associated with cholangiocarcinoma
3) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.77 Pain Relevance 0
This finding that shows that patients with low expression of CD24 may benefit from chemotherapy or radiation is of importance because it has been previously reported that adjuvant or palliative radiation had no effect on survival in patients with cholangiocarcinoma.41 However, the small number of patients in the present series limits interpretation of data suggesting that CD24 overexpression may be predictive of lack of response to radiation or chemotherapy.
Gene_expression (overexpression) of CD24 associated with cholangiocarcinoma and palliative
4) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.89 Pain Relevance 0.10
Furthermore, correlation between CD24 expression and radiation sensitivity has been noted to vary with the cell type as in human small cell lung cancer, and radiation doses required to induce apoptosis of CD24-negative human ALL (acute lymphoblastic leukemia) cells were higher than those required for CD24-positive cells, suggesting that lack of CD24 surface antigen expression is associated with intrinsic radiation resistance.34,35
Gene_expression (expression) of CD24 in lung associated with leukemia, lung cancer and apoptosis
5) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.93 Pain Relevance 0
Our data indicate that high expression of CD24 remains an adverse prognosticator despite the use of additional therapy.
Gene_expression (expression) of CD24
6) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.60 Pain Relevance 0
The cholangiocarcinoma cells were scored as 1+ when they demonstrated weak expression of CD24, 2+ for moderate expression, and 3+ for strong expression of CD24.
Gene_expression (expression) of CD24 associated with cholangiocarcinoma
7) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.63 Pain Relevance 0.12
The cholangiocarcinoma cells were scored as 1+ when they demonstrated weak expression of CD24, 2+ for moderate expression, and 3+ for strong expression of CD24.
Gene_expression (expression) of CD24 associated with cholangiocarcinoma
8) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.61 Pain Relevance 0.12
Su et al. noted a 51% expression of CD24 by immunohistochemistry in intrahepatic cholangiocarcinoma as compared to the 81.8% in the present series.
Gene_expression (expression) of CD24 associated with cholangiocarcinoma
9) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.72 Pain Relevance 0.06
Overexpression of CD24 continued to affect survival adversely despite the overall improvement noted with the addition of radiation therapy.
Gene_expression (Overexpression) of CD24
10) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.23 Pain Relevance 0.03
They reported CD24 expression and tumor stage as independently predictive of survival on multivariate analysis and suggested membrane-bound CD24 protein as a potential target for immunotherapy.8
Gene_expression (expression) of CD24 associated with cancer
11) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.74 Pain Relevance 0.06
Furthermore, correlation between CD24 expression and radiation sensitivity has been noted to vary with the cell type as in human small cell lung cancer, and radiation doses required to induce apoptosis of CD24-negative human ALL (acute lymphoblastic leukemia) cells were higher than those required for CD24-positive cells, suggesting that lack of CD24 surface antigen expression is associated with intrinsic radiation resistance.34,35
Gene_expression (expression) of CD24 in lung associated with leukemia, lung cancer and apoptosis
12) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 1.20 Pain Relevance 0
A negative association was suggested between the expression of CD24 and phosphorylated/activated p-MAPK (Kendall’s ??
Gene_expression (expression) of CD24
13) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.38 Pain Relevance 0.10
Figure 1 depicts cholangiocarcinoma positive for CD24 expression adjacent to normal biliary epithelium.
Gene_expression (expression) of CD24 in biliary epithelium associated with cholangiocarcinoma
14) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 0.58 Pain Relevance 0.12
This finding that shows that patients with low expression of CD24 may benefit from chemotherapy or radiation is of importance because it has been previously reported that adjuvant or palliative radiation had no effect on survival in patients with cholangiocarcinoma.41 However, the small number of patients in the present series limits interpretation of data suggesting that CD24 overexpression may be predictive of lack of response to radiation or chemotherapy.
Gene_expression (expression) of CD24 associated with cholangiocarcinoma and palliative
15) Confidence 0.78 Published 2007 Journal J Gastrointest Surg Section Body Doc Link PMC1852393 Disease Relevance 1.20 Pain Relevance 0.10
To test the expression efficiency of the CD24 alleles, we transfected varying concentrations of plasmids into CHO cells using FuGENE 6 (Roche, http://www.roche.com).
Gene_expression (expression) of CD24
16) Confidence 0.78 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0 Pain Relevance 0
Recently, we showed that CD24 is essential for local clonal expansion and persistence of T cells after their migration into the central nervous system and that expression of CD24 on either hematopoietic cells or nonhematopoietic antigen-presenting cells in the recipient is sufficient to confer susceptibility to EAE [25].
Gene_expression (expression) of CD24 in T cells associated with multiple sclerosis and central nervous system
17) Confidence 0.78 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 1.54 Pain Relevance 0.27
The low expression of CD24 in T cells is essential for homeostatic proliferation of T cells, which has been implicated in the development of autoimmune diseases.
Gene_expression (expression) of CD24 in T cells associated with autoimmune disease
18) Confidence 0.78 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.63 Pain Relevance 0.11
Since CD24 was expressed at high levels among some lineages of hematopoietic cells and in the transfected CHO cells, the reduction in the steady levels may underestimate the reduction in other cell types, such as T cells, in which CD24 is expressed at lower levels and is therefore less likely to saturate the degradation system.
Gene_expression (expressed) of CD24 in T cells
19) Confidence 0.78 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.54 Pain Relevance 0.10
Since CD24 was expressed at high levels among some lineages of hematopoietic cells and in the transfected CHO cells, the reduction in the steady levels may underestimate the reduction in other cell types, such as T cells, in which CD24 is expressed at lower levels and is therefore less likely to saturate the degradation system.
Gene_expression (expressed) of CD24 in T cells
20) Confidence 0.78 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1847692 Disease Relevance 0.40 Pain Relevance 0.07

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