INT19181

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Context Info
Confidence 0.68
First Reported 1991
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 35
Total Number 39
Disease Relevance 16.93
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Bche) extracellular region (Bche) endoplasmic reticulum (Bche)
Anatomy Link Frequency
plasma 10
molar 2
neuronal 1
nerve 1
brain 1
Bche (Mus musculus)
Pain Link Frequency Relevance Heat
Abeta 3 100.00 Very High Very High Very High
aspirin 1 99.30 Very High Very High Very High
antagonist 66 97.96 Very High Very High Very High
Chronic pancreatitis 1 97.68 Very High Very High Very High
agonist 76 95.20 Very High Very High Very High
anesthesia 55 94.32 High High
fortral 26 87.32 High High
nMDA receptor 23 85.40 High High
Clonidine 5 83.04 Quite High
cocaine 87 72.80 Quite High
Disease Link Frequency Relevance Heat
Cytomegalovirus Infection 286 100.00 Very High Very High Very High
Targeted Disruption 1433 99.76 Very High Very High Very High
Toxicity 74 98.52 Very High Very High Very High
Pancreatic Cancer 3 98.44 Very High Very High Very High
Disease 529 98.36 Very High Very High Very High
Neuromuscular Disease 1 98.08 Very High Very High Very High
Aging 46 97.78 Very High Very High Very High
Pancreatitis 3 97.68 Very High Very High Very High
Cognitive Disorder 115 96.72 Very High Very High Very High
Coagulation Disorder 26 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Organophosphorus pesticide-induced butyrylcholinesterase inhibition and potentiation of succinylcholine toxicity in mice.
Gene_expression (inhibition) of butyrylcholinesterase associated with aspirin and toxicity
1) Confidence 0.68 Published 1999 Journal J. Biochem. Mol. Toxicol. Section Title Doc Link 9890196 Disease Relevance 0.38 Pain Relevance 0.14
The recovery profile was shorter in the remifentanil group the drug being rapidly metabolised by plasma cholinesterase.
Gene_expression (metabolised) of plasma cholinesterase in plasma
2) Confidence 0.56 Published 2002 Journal Minerva Anestesiol Section Body Doc Link 12370680 Disease Relevance 0 Pain Relevance 0
Increased cholinesterase levels were observed in workers handling fluorine compounds in a plastics factory [10].
Gene_expression (levels) of cholinesterase
3) Confidence 0.49 Published 2002 Journal Crit Care Section Body Doc Link PMC137451 Disease Relevance 0.39 Pain Relevance 0.30
Additional research is warranted to determine whether cholinesterase inhibitors and antioxidants, such as vitamin E, provide any significant benefit in the prevention and treatment of AD.


Gene_expression (inhibitors) of cholinesterase associated with disease
4) Confidence 0.48 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.72 Pain Relevance 0
Rivastigmine (Novartis Pharmaceuticals Corporation, NJ, USA) is a dual acting inhibitor that targets both acetylcholinesterase and butyrylcholinesterase.
Gene_expression (targets) of butyrylcholinesterase
5) Confidence 0.42 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 1.49 Pain Relevance 0
Aging and its variants, such as AD, should be viewed as the result of multiple "hits," including alterations in the levels of Abeta, metals, cholinesterase enzymes, and neuronal gene expression.
Gene_expression (levels) of cholinesterase in neuronal associated with aging, disease and abeta
6) Confidence 0.40 Published 2005 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 16387707 Disease Relevance 1.39 Pain Relevance 0.13
One way to achieve plasma stability and longer half-life of recombinant BChE while maintaining its biological activity is to provide a recombinantly produced BChE fused to human serum albumin (hSA).
Gene_expression (produced) of BChE in plasma
7) Confidence 0.40 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.18 Pain Relevance 0.03
Expression of BChE/hSA in the milk of transgenic mice and goats represents just another good example.
Gene_expression (Expression) of BChE associated with targeted disruption
8) Confidence 0.40 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.53 Pain Relevance 0
Pharmacokinetic study on BChE/hSA produced in vitro
Gene_expression (produced) of BChE
9) Confidence 0.40 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.06 Pain Relevance 0
Given the fact that the recombinant human BChE expressed in the milk of transgenic goats is mainly in the dimer form [14], it is not surprised that the major eluted fusion protein peaks from the milk of transgenic mice and goats by SEC-HPLC are dimers in size.
Gene_expression (expressed) of BChE associated with targeted disruption
10) Confidence 0.34 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.63 Pain Relevance 0
For a BChE preparation with >70% tetramer, recombinant BChE produced from milk of transgenic goats was purified [14] and polyproline (Sigma-Aldrich) was added to the purified recombinant BChE at molar ratio of 2:1 to maximize tetramer formation.
Gene_expression (produced) of BChE in molar associated with targeted disruption
11) Confidence 0.34 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.18 Pain Relevance 0
The results clearly revealed a substantial enhancement of the plasma half-life of the fusion protein (~32 h) when compared with the recombinant BChE transgenically produced in goat milk and enriched to contain more than 70% tetramer (~3 h) (Table 1; Fig. 2).


Gene_expression (produced) of BChE in plasma
12) Confidence 0.34 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.27 Pain Relevance 0
Plasma BChE activity in juvenile pigs following a single i.v. injection of 10 mg/kg BChE/hSA, produced in vitro and partially purified, or 10 mg/kg tetramer-enriched BChE, produced in vivo and purified, was analyzed using the Ellman assay with background BChE activity subtracted (Fig. 2A and 2B).
Gene_expression (produced) of BChE in Plasma
13) Confidence 0.34 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.05 Pain Relevance 0
There were no detectable levels of BChE/hSA in the F1 females from the male line, probably due to the low copy number of the transgene integrated (data not shown).
Neg (no) Gene_expression (detectable) of BChE
14) Confidence 0.34 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.47 Pain Relevance 0
Plasma BChE activity in juvenile pigs following a single i.v. injection of 10 mg/kg BChE/hSA, produced in vitro and partially purified, or 10 mg/kg tetramer-enriched BChE, produced in vivo and purified, was analyzed using the Ellman assay with background BChE activity subtracted (Fig. 2A and 2B).
Gene_expression (produced) of BChE in Plasma
15) Confidence 0.34 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.06 Pain Relevance 0
Pharmacokinetic study on BChE/hSA produced in vitro
Gene_expression (/) of BChE
16) Confidence 0.34 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.06 Pain Relevance 0
Three F0 founder mice, two females and one male, were generated by pronuclear microinjection with the in vivo DNA expression vector, bCN/BChE/hSA.
Gene_expression (expression) of BChE
17) Confidence 0.34 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.41 Pain Relevance 0
There were no detectable levels of BChE/hSA in the F1 females from the male line, probably due to the low copy number of the transgene integrated (data not shown).
Neg (no) Gene_expression (levels) of BChE
18) Confidence 0.34 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.47 Pain Relevance 0
The level of BChE activity in cell culture media from CMV/BChE/hSA transfected BHK cells was evaluated using a commercially available kit (Sigma-Aldrich).
Gene_expression (transfected) of BChE associated with cytomegalovirus infection
19) Confidence 0.31 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.27 Pain Relevance 0
Goat 2177 expressed BChE/hSA in the milk in average ~1.1 g/liter whereas the others expressed at 0.04–0.3 g/liter, as determined by the Ellman assay (Table 2).
Spec (determined) Gene_expression (expressed) of BChE
20) Confidence 0.31 Published 2008 Journal BMC Biotechnol Section Body Doc Link PMC2415180 Disease Relevance 0.61 Pain Relevance 0

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