INT191823

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Context Info
Confidence 0.30
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.95
Pain Relevance 0.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TGM2) plasma membrane (TGM2) transferase activity, transferring acyl groups (TGM2)
cytoplasm (TGM2)
Anatomy Link Frequency
small intestine 1
TGM2 (Homo sapiens)
Pain Link Frequency Relevance Heat
withdrawal 2 93.60 High High
Inflammation 24 78.96 Quite High
Pain 3 68.72 Quite High
nud 1 66.40 Quite High
cytokine 10 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
Infliximab 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Celiac Disease 60 99.40 Very High Very High Very High
Disease 86 99.00 Very High Very High Very High
Malabsorption Syndromes 83 99.00 Very High Very High Very High
Reprotox - General 3 2 87.60 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 80.24 Quite High
INFLAMMATION 27 78.96 Quite High
Cervical Intraepithelial Neoplasia 1 74.84 Quite High
Papillomavirus Infection 3 71.56 Quite High
Arthralgia 1 68.72 Quite High
Neurodegenerative Disease 2 68.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TG2 is a pleiotropic enzyme found both intracellularly and extracellularly in many tissues and organs, including the small intestine, where it is upregulated during active celiac sprue [128–130].
Positive_regulation (upregulated) of TG2 in small intestine associated with celiac disease
1) Confidence 0.30 Published 2008 Journal PLoS Pathogens Section Body Doc Link PMC2323203 Disease Relevance 0.49 Pain Relevance 0
The exact cause of celiac disease is unknown but is thought to be primarily immune mediated (tissue-transglutaminase autoantigen); often the disease is inherited.
Positive_regulation (mediated) of tissue-transglutaminase associated with malabsorption syndromes and disease
2) Confidence 0.08 Published 2006 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC1435993 Disease Relevance 1.46 Pain Relevance 0.25

General Comments

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