INT191825

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Context Info
Confidence 0.12
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.50
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
T cells 6
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 17 99.16 Very High Very High Very High
Inflammation 34 98.96 Very High Very High Very High
Leflunomide 54 96.74 Very High Very High Very High
rheumatoid arthritis 40 88.52 High High
Arthritis 33 56.72 Quite High
metalloproteinase 1 40.76 Quite Low
chemokine 3 39.52 Quite Low
fibrosis 1 12.80 Low Low
withdrawal 3 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 38 98.96 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 49 97.44 Very High Very High Very High
Infection 16 93.12 High High
Malabsorption Syndromes 83 91.88 High High
Viral Infection 2 89.28 High High
Rheumatoid Arthritis 41 88.52 High High
Disease 29 87.92 High High
Cancer 6 83.60 Quite High
Cytomegalovirus Infection 4 74.24 Quite High
Congenital Anomalies 3 67.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we performed a randomized, double-blinded, placebo-controlled pilot study of leflunomide administered to HIV infected participants who were not on antiretroviral therapy in order to assess its safety and tolerability in this population as well as its effect on cycling and activation of CD4 and CD8 T cells.


Regulation (effect) of Positive_regulation (activation) of CD8 in T cells associated with acquired immune deficiency syndrome or hiv infection and leflunomide
1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914784 Disease Relevance 1.07 Pain Relevance 0.27
In addition, the increase in CD8+ T cells in the epithelium of the mucosa (IEL) cannot be explained by HLA-DQ2 positive cells, which only activate CD4+ T cells.
Regulation (explained) of Positive_regulation (increase) of CD8 in T cells
2) Confidence 0.06 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1435993 Disease Relevance 0.55 Pain Relevance 0
B activation, such as pro-inflammatory cytokines and ligation of Toll-like receptors, but triggering of highly specialized antigen receptors such as the T-cell receptor is also dependent on this pathway [12].
Regulation (dependent) of Positive_regulation (triggering) of T-cell receptor in T-cell associated with inflammation and cytokine
3) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 0.88 Pain Relevance 0.34

General Comments

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