INT191825

Context Info Confidence 0.12 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 2.50 Pain Relevance 0.62

extracellular region (CD8A) plasma membrane (CD8A)

Anatomy Link Frequency T cells 6 CD8A (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 17 99.16 Inflammation 34 98.96 Leflunomide 54 96.74 rheumatoid arthritis 40 88.52 Arthritis 33 56.72 metalloproteinase 1 40.76 chemokine 3 39.52 fibrosis 1 12.80 withdrawal 3 5.00 depression 3 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 38 98.96 Acquired Immune Deficiency Syndrome Or Hiv Infection 49 97.44 Infection 16 93.12 Malabsorption Syndromes 83 91.88 Viral Infection 2 89.28 Rheumatoid Arthritis 41 88.52 Disease 29 87.92 Cancer 6 83.60 Cytomegalovirus Infection 4 74.24 Congenital Anomalies 3 67.96

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this study, we performed a randomized, double-blinded, placebo-controlled pilot study of leflunomide administered to HIV infected participants who were not on antiretroviral therapy in order to assess its safety and tolerability in this population as well as its effect on cycling and activation of CD4 and CD8 T cells.

Regulation (effect) of Positive_regulation (activation) of CD8 in T cells associated with acquired immune deficiency syndrome or hiv infection and leflunomide

1) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2914784 Disease Relevance 1.07 Pain Relevance 0.27

In addition, the increase in CD8+ T cells in the epithelium of the mucosa (IEL) cannot be explained by HLA-DQ2 positive cells, which only activate CD4+ T cells.

Regulation (explained) of Positive_regulation (increase) of CD8 in T cells

2) Confidence 0.06 Published 2006 Journal Orphanet J Rare Dis Section Body Doc Link PMC1435993 Disease Relevance 0.55 Pain Relevance 0

B activation, such as pro-inflammatory cytokines and ligation of Toll-like receptors, but triggering of highly specialized antigen receptors such as the T-cell receptor is also dependent on this pathway [12].

Regulation (dependent) of Positive_regulation (triggering) of T-cell receptor in T-cell associated with inflammation and cytokine

3) Confidence 0.03 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1779420 Disease Relevance 0.88 Pain Relevance 0.34

General Comments

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