INT191831

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Context Info
Confidence 0.49
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 3.66
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a3) plasma membrane (Slc1a3)
Anatomy Link Frequency
retina 1
whisker 1
Slc1a3 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 96 100.00 Very High Very High Very High
imagery 21 94.64 High High
excitatory amino acid 1 94.32 High High
Somatosensory cortex 3 94.08 High High
cerebral cortex 4 75.80 Quite High
positron emission tomography 20 74.56 Quite High
Central nervous system 13 73.44 Quite High
cytokine 18 71.76 Quite High
Neurotransmitter 3 56.64 Quite High
anesthesia 9 37.28 Quite Low
Disease Link Frequency Relevance Heat
Cancer 141 99.84 Very High Very High Very High
Hypoxia 24 98.76 Very High Very High Very High
Injury 119 93.80 High High
Stab Wounds 30 93.52 High High
Gliosis 4 91.76 High High
Hyperplasia 3 91.64 High High
Neurodegenerative Disease 20 88.64 High High
Aggression 1 87.36 High High
Penetrating Head Injuries 10 80.72 Quite High
Brain Injury 20 75.92 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using Western blot analysis on single barrel columns corresponding to the stimulated whisker, we found that expression levels of GLT1 and GLAST were significantly increased.
Positive_regulation (increased) of GLAST in whisker
1) Confidence 0.49 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1609127 Disease Relevance 0.15 Pain Relevance 0.27
Glucose transporter (GLUT) receptor proteins and hexokinase activity are elevated in tumors and thought to be responsible for increased 18F-FDG tumor uptake compared to normal tissues [19].
Positive_regulation (elevated) of GLUT associated with cancer
2) Confidence 0.45 Published 2006 Journal Radiat Oncol Section Body Doc Link PMC1436004 Disease Relevance 1.51 Pain Relevance 0.12
Studies from our lab indicate that there is a dramatic induction of GLAST protein in WT and IL-1R1-null mice after a mild hypoxic/ischemic insult (Sen et al. unpublished observation).
Positive_regulation (induction) of GLAST protein associated with hypoxia
3) Confidence 0.44 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1533808 Disease Relevance 0.82 Pain Relevance 0.21
Finally, Vim mRNA is expressed at a roughly similar level, while significantly fewer cFos, Slc1a3, and Grm1 transcripts are expressed in the WT mouse retina.
Positive_regulation (fewer) of Slc1a3 in retina
4) Confidence 0.43 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2719914 Disease Relevance 0.07 Pain Relevance 0
However, the induction of chondroitin sulfate proteoglycans, tenascin, S-100B as well as glutamate transporter proteins, GLAST and GLT-1, and glutamine synthetase are independent of IL-1RI signaling.
Positive_regulation (induction) of GLAST associated with glutamate
5) Confidence 0.29 Published 2006 Journal J Neuroinflammation Section Abstract Doc Link PMC1533808 Disease Relevance 0.73 Pain Relevance 0.09
Here we found that many BrdU-positive cells were also positive for vGluT mRNA (Fig. 6) and limNOS2 mRNA (Fig.
Positive_regulation (positive) of vGluT
6) Confidence 0.00 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2816995 Disease Relevance 0.39 Pain Relevance 0.18

General Comments

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