INT191862

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Context Info
Confidence 0.79
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 6.89
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Tlr4) plasma membrane (Tlr4) intracellular (Tlr4)
cytoplasm (Tlr4)
Anatomy Link Frequency
brain 1
nucleus 1
peritoneal macrophages 1
Tlr4 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 207 100.00 Very High Very High Very High
agonist 19 99.82 Very High Very High Very High
antidepressant 45 96.56 Very High Very High Very High
tolerance 51 96.20 Very High Very High Very High
Angina 10 93.60 High High
Desipramine 49 82.48 Quite High
Kinase C 26 82.36 Quite High
fluoxetine 47 81.28 Quite High
Inflammatory response 42 77.16 Quite High
cytokine 132 70.92 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 256 100.00 Very High Very High Very High
Bacterial Infection 12 99.80 Very High Very High Very High
Hypotension 6 99.64 Very High Very High Very High
Cancer 99 98.68 Very High Very High Very High
Acute Coronary Syndrome 17 98.68 Very High Very High Very High
Necrosis 16 98.44 Very High Very High Very High
Pneumonia 23 98.24 Very High Very High Very High
Septic Shock 22 96.60 Very High Very High Very High
Sepsis 57 95.04 Very High Very High Very High
Cv General 2 Under Development 5 94.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The correlation between TLR4 and TNF-?
Phosphorylation (correlation) of TLR4
1) Confidence 0.79 Published 2010 Journal Clinical Medicine Insights. Cardiology Section Body Doc Link PMC2956475 Disease Relevance 1.11 Pain Relevance 0.17
Phosphorylated STAT3 was not detected in the brain nuclear fraction of vehicle-injected mice (Fig. 6D and 6E); however, after LPS, phosphorylated STAT3 protein level increased in both genotypes, but was increased to a greater extent in COX-2-/- mice (Fig. 6D and 6E).


Phosphorylation (phosphorylated) of LPS in brain
2) Confidence 0.60 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.14 Pain Relevance 0.11
The protein levels of p67phox (Fig. 7C and 7D) and phosphorylated STAT3 after LPS (Fig. 7E and 7F) were also higher in the celecoxib-treated mice compared to untreated mice.


Phosphorylation (phosphorylated) of LPS
3) Confidence 0.53 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2409311 Disease Relevance 0.05 Pain Relevance 0.09
These results are consensually supported by the studies in which TLR4 activation inhibits phosphorylation and nucleus translocation of Stat3 [21] and activated Stat3 inhibits TLR4 signaling in return via inhibiting transcriptional or translational activity of NF-?
Phosphorylation (phosphorylation) of TLR4 in nucleus
4) Confidence 0.51 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716531 Disease Relevance 1.28 Pain Relevance 0.12
Kinase phosphorylation downstream of ceramide/TLR4
Phosphorylation (phosphorylation) of TLR4
5) Confidence 0.50 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2944801 Disease Relevance 0.13 Pain Relevance 0
This may, in part, result from the fact that key posttranslational modifications, e.g., phosphorylation, to TLR4 do not occur in tolerized cells (14).
Phosphorylation (phosphorylation) of TLR4
6) Confidence 0.46 Published 2010 Journal mBio Section Body Doc Link PMC2962435 Disease Relevance 0.19 Pain Relevance 0.35
As shown in Figure 2C, pretreatment with TLR4 antibody also inhibited LPS-stimulated phosphorylation of NF-?
Phosphorylation (phosphorylation) of LPS
7) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3002338 Disease Relevance 0.15 Pain Relevance 0.04
NO radical increased gradually at 2 h and increased rapidly at 4 h after LPS injection.
Phosphorylation (injection) of LPS
8) Confidence 0.40 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386525 Disease Relevance 0.82 Pain Relevance 0.04
Coincident with alleviation of LPS-induced hypotension, PAF treatment markedly reduced NO production (Figure 3D, E).
Phosphorylation (alleviation) of LPS associated with hypotension
9) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2714981 Disease Relevance 1.07 Pain Relevance 0.03
miR-155 regulates c/ebp Beta in the splenocytes of LPS-treated mice
Phosphorylation (splenocytes) of LPS
10) Confidence 0.33 Published 2009 Journal Nucleic Acids Research Section Body Doc Link PMC2761263 Disease Relevance 0 Pain Relevance 0
Previously LPS-induced p38 and ERK phosphorylation was reduced in bone-marrow derived DCs treated with ~40 ?
Phosphorylation (phosphorylation) of LPS
11) Confidence 0.32 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2993695 Disease Relevance 0.06 Pain Relevance 0
Although Pb alone or LPS alone slightly increased the phosphorylation of MAPK in peritoneal macrophages, only coexposing them to Pb+LPS induced obvious p42/44 MAPK phosphorylation and TNF-?
Phosphorylation (phosphorylation) of LPS in peritoneal macrophages
12) Confidence 0.24 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0 Pain Relevance 0.14
These results rule out a possible effect of LPS on Syk phosphorylation.
Phosphorylation (phosphorylation) of LPS
13) Confidence 0.15 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0 Pain Relevance 0
The switch in Lewis antigen expression suggests that different gastric environments, and possibly gastric pH, can influence the fucosylation of LPS.
Phosphorylation (fucosylation) of LPS
14) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.35 Pain Relevance 0
LPS isolation
Phosphorylation (isolation) of LPS
15) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2690825 Disease Relevance 0.05 Pain Relevance 0
In addition, the same A2A agonist reduced LPS-induced microvascular permeability and secretion of interleukin-6, tumor necrosis factor-?
Phosphorylation (permeability) of LPS associated with necrosis, cancer and agonist
16) Confidence 0.11 Published 2008 Journal Crit Care Section Body Doc Link PMC2592730 Disease Relevance 1.04 Pain Relevance 0.44
LPS-induced inflammation and endotoxic shock in mice
Phosphorylation (inflammation) of LPS associated with inflammation and bacterial infection
17) Confidence 0.06 Published 2007 Journal Respir Res Section Body Doc Link PMC1876225 Disease Relevance 0.42 Pain Relevance 0.22

General Comments

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