INT19187

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Context Info
Confidence 0.73
First Reported 1991
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 24
Total Number 30
Disease Relevance 19.72
Pain Relevance 5.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Lgals3) extracellular region (Lgals3) mRNA processing (Lgals3)
proteinaceous extracellular matrix (Lgals3) plasma membrane (Lgals3) nucleus (Lgals3)
Anatomy Link Frequency
inflammatory macrophages 4
macrophages 1
platelet 1
fibroblasts 1
eosinophils 1
Lgals3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
depression 336 99.28 Very High Very High Very High
Chronic pancreatitis 19 98.56 Very High Very High Very High
qutenza 10 97.12 Very High Very High Very High
Inflammation 87 96.64 Very High Very High Very High
fibrosis 98 91.08 High High
Inflammatory mediators 4 90.72 High High
dexamethasone 2 90.52 High High
aspirin 2 87.64 High High
cINOD 2 87.28 High High
Morphine 3 59.28 Quite High
Disease Link Frequency Relevance Heat
Immunization 39 100.00 Very High Very High Very High
Diabetic Retinopathy 119 99.92 Very High Very High Very High
Diabetes Complications 7 99.92 Very High Very High Very High
Asthma 39 99.78 Very High Very High Very High
Diabetes Mellitus 438 99.76 Very High Very High Very High
Anxiety Disorder 436 99.76 Very High Very High Very High
Primary Sclerosing Cholangitis 2 99.56 Very High Very High Very High
Depression 336 99.28 Very High Very High Very High
Conjunctiva Disease 54 99.24 Very High Very High Very High
Eczema 436 99.06 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that all immunomodulatory drugs applied in clinically relevant doses affect both the gene (LGALS3) and protein expression level of galectin-3.
Gene_expression (expression) of galectin-3
1) Confidence 0.73 Published 2006 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16458432 Disease Relevance 0.18 Pain Relevance 0.22
The results showed that all immunomodulatory drugs applied in clinically relevant doses affect both the gene (LGALS3) and protein expression level of galectin-3.
Gene_expression (expression) of LGALS3
2) Confidence 0.73 Published 2006 Journal Biochim. Biophys. Acta Section Abstract Doc Link 16458432 Disease Relevance 0.18 Pain Relevance 0.22
Following the demonstration 25 years ago that substituted ammonium groups on neuromuscular blocking drugs (NMBDs) are the main allergenic structures recognized by IgE antibodies in the sera of some patients who experience anaphylaxis during anaesthesia, immunoassays for these drugs were quickly applied to supplement skin tests in the diagnostic assessment of suspected adverse reactions to anaesthetic agents.
Gene_expression (antibodies) of IgE in skin associated with adverse drug reaction and anaphylaxis
3) Confidence 0.67 Published 2009 Journal Clin. Exp. Allergy Section Abstract Doc Link 19187323 Disease Relevance 0.31 Pain Relevance 0.06
Lgals3 expression has previously been reported to increase in Muller cells of diabetic rats in association with increased acute phase genes [30].
Gene_expression (expression) of Lgals3 in Muller cells associated with diabetes mellitus
4) Confidence 0.66 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.75 Pain Relevance 0.08
Lgals3 (lectin, galactoside-binding, soluble 3; galectin-3) is an abundant protein expressed in the nucleus, cytoplasm, mitochondria, and plasma membrane of multiple cell types including inflammatory macrophages [59], retinal Müller glia [30] and endothelial cells [60].
Gene_expression (expressed) of lectin in inflammatory macrophages associated with inflammation
5) Confidence 0.66 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.55 Pain Relevance 0.05
It is likely that increased Lgals3 expression with diabetes is mediated by increased AGE formation [64], [65] and contributes to inflammatory [66] and vascular components of retinal complications.
Gene_expression (expression) of Lgals3 in vascular components associated with inflammation and diabetes mellitus
6) Confidence 0.66 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.87 Pain Relevance 0.15
Insulin treatment partially normalized the protein expression of Cp, Lgals3, and Stat3 with the insulin-treated group no longer significantly elevated from control but also not significantly lower than the diabetic group (Figure 7).
Gene_expression (expression) of Lgals3 associated with diabetes mellitus
7) Confidence 0.66 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.31 Pain Relevance 0
Lgals3 (lectin, galactoside-binding, soluble 3; galectin-3) is an abundant protein expressed in the nucleus, cytoplasm, mitochondria, and plasma membrane of multiple cell types including inflammatory macrophages [59], retinal Müller glia [30] and endothelial cells [60].
Gene_expression (expressed) of Lgals3 in inflammatory macrophages associated with inflammation
8) Confidence 0.66 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.55 Pain Relevance 0.05
Lgals3 (lectin, galactoside-binding, soluble 3; galectin-3) is an abundant protein expressed in the nucleus, cytoplasm, mitochondria, and plasma membrane of multiple cell types including inflammatory macrophages [59], retinal Müller glia [30] and endothelial cells [60].
Gene_expression (expressed) of soluble 3 in inflammatory macrophages associated with inflammation
9) Confidence 0.51 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.55 Pain Relevance 0.05
Lgals3 (lectin, galactoside-binding, soluble 3; galectin-3) is an abundant protein expressed in the nucleus, cytoplasm, mitochondria, and plasma membrane of multiple cell types including inflammatory macrophages [59], retinal Müller glia [30] and endothelial cells [60].
Gene_expression (expressed) of galectin-3 in inflammatory macrophages associated with inflammation
10) Confidence 0.51 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020973 Disease Relevance 0.55 Pain Relevance 0.05
On this basis, we considered IgE levels as a possible explanatory factor in the association between anxiety, depression, and eczema, but we recently published that there is no association between IgE levels, and anxiety and depression [17].
Gene_expression (levels) of IgE associated with depression, anxiety disorder and eczema
11) Confidence 0.32 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2876073 Disease Relevance 1.85 Pain Relevance 0.33
On the basis of this nil finding, IgE levels cannot be a mediating or confounding factor in the association of interest.
Gene_expression (levels) of IgE
12) Confidence 0.32 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2876073 Disease Relevance 1.80 Pain Relevance 0.31
On this basis, we considered IgE levels as a possible explanatory factor in the association between anxiety, depression, and eczema, but we recently published that there is no association between IgE levels, and anxiety and depression [17].
Gene_expression (levels) of IgE associated with depression, anxiety disorder and eczema
13) Confidence 0.32 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2876073 Disease Relevance 1.60 Pain Relevance 0.34
The average IgE titers measured by ELISA after the fourth immunization and expressed as optical density in Control, Total-C-C, Filtered-C-C, C-Total-C, C-Filtered-C, C-C-Total and C-C-Filtered were 0.47 ± 0.06, 0.79 ± 0.35, 0.86 ± 0.46, 0.80 ± 0.22, 0.56 ± 0.08, 0.46 ± 0.04 and 0.45 ± 0.03, respectively.
Gene_expression (expressed) of IgE associated with immunization
14) Confidence 0.28 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.49 Pain Relevance 0
A substantial part of the psychodermatological literature has focused on atopic forms of eczema, and many of the above referred hypotheses concerning possible explanatory factors for the association between anxiety and depression, and eczema presuppose the involvement of atopy (elevated levels of IgE, in addition to "atopic symptoms" [16]) as a part of the aetiological chain underlying this association.
Gene_expression (levels) of IgE associated with asthma, depression, anxiety disorder and eczema
15) Confidence 0.28 Published 2010 Journal BMC Dermatol Section Body Doc Link PMC2876073 Disease Relevance 1.59 Pain Relevance 0.31
Log2 P-K IgE titers of each group are shown in Table 3.
Gene_expression (titers) of IgE
16) Confidence 0.25 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.55 Pain Relevance 0
Elevated IgE was also detected in the rats exposed to diesel exhaust directly during the suckling period, C-Total-C and C-Filtered-C.
Gene_expression (detected) of IgE
17) Confidence 0.22 Published 2002 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC101391 Disease Relevance 0.07 Pain Relevance 0
In situ hybridization analysis of normal pancreas indicated low abundance of galectin-1 mRNA in fibroblasts, whereas galectin-3 mRNA was moderately present in ductal cells.
Gene_expression (present) of galectin-3 mRNA in fibroblasts
18) Confidence 0.17 Published 2000 Journal Lab. Invest. Section Abstract Doc Link 10950114 Disease Relevance 0.72 Pain Relevance 0.64
Concanavalin A (ConA) is a lectin extracted from Cannavalia ensiformis (Jack bean) with selectivity for methyl ?
Gene_expression (is) of lectin
19) Confidence 0.16 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2636009 Disease Relevance 0.70 Pain Relevance 0
Role of concanavalin A lectin in recognition of pterygium remnant after surgical excision: Preliminary results of a prospective study

Background:

Pterygium is one of the most common conjunctival diseases among ophthalmic pathologies. 
Gene_expression (Role) of lectin associated with conjunctiva disease and conjunctival diseases
20) Confidence 0.14 Published 2007 Journal Indian Journal of Ophthalmology Section Title Doc Link PMC2636009 Disease Relevance 0.73 Pain Relevance 0

General Comments

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