INT191879

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Context Info
Confidence 0.01
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.25
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Mapk3) transport (Pbsn) protein complex assembly (Mapk3)
protein complex (Mapk3) cytoplasm (Mapk3) cytosol (Mapk3)
Anatomy Link Frequency
liver 2
hepatocytes 1
Pbsn (Mus musculus)
Mapk3 (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 26 100.00 Very High Very High Very High
Inflammation 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Calcium channel 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatocellular Cancer 1 88.76 High High
Poisoning 1 83.44 Quite High
Glioma 1 80.16 Quite High
Injury 20 50.00 Quite Low
Cancer 4 50.00 Quite Low
Necrosis 3 50.00 Quite Low
Death 2 32.32 Quite Low
Disease 5 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Sepsis 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because circulating Pb will quickly deposit in the liver (Bornemann and Colburn 1985), we speculated (Cheng and Liu 2005) that a transient accumulation of Pb in the liver will suppress the activation of PKC and p42/44 MAPK in hepatocytes.
Positive_regulation (accumulation) of Pb in hepatocytes Negative_regulation (suppress) of Positive_regulation (activation) of p42/44 MAPK in liver associated with kinase c
1) Confidence 0.01 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0.25 Pain Relevance 0.23

General Comments

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