INT19189

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Context Info
Confidence 0.78
First Reported 1988
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 9.02
Pain Relevance 3.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (IL1A) cytosol (IL1A) extracellular space (IL1A)
extracellular region (IL1A)
Anatomy Link Frequency
plaques 3
epithelial cells 3
chondrocyte 1
monocytes 1
immune system 1
IL1A (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 102 100.00 Very High Very High Very High
Inflammation 42 100.00 Very High Very High Very High
cINOD 19 99.64 Very High Very High Very High
Abeta 4 90.24 High High
Inflammatory mediators 5 86.20 High High
aspirin 4 85.40 High High
dexamethasone 1 82.72 Quite High
rheumatoid arthritis 35 80.88 Quite High
Osteoarthritis 4 79.80 Quite High
Inflammatory response 5 74.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 62 100.00 Very High Very High Very High
Cancer 13 100.00 Very High Very High Very High
Necrosis 7 100.00 Very High Very High Very High
Amyloid Plaque 7 99.84 Very High Very High Very High
Osteogenic Sarcomas 8 99.76 Very High Very High Very High
Hemophilus Infection 240 99.20 Very High Very High Very High
Choroideremia 166 98.84 Very High Very High Very High
Disease 100 97.92 Very High Very High Very High
Alzheimer's Dementia 30 96.96 Very High Very High Very High
Injury 2 91.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
But IL-1alpha release was not attenuated by SKI306X.
Localization (release) of IL-1alpha
1) Confidence 0.78 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16141526 Disease Relevance 0.74 Pain Relevance 0.48
We developed an ELISA system for human IL-1 alpha and -beta release from silica-stimulated monocytes from healthy volunteers and tested the effect of several anti-rheumatic drugs including nonsteroidal anti-inflammatory drug (Ibuprofen).
Localization (release) of IL-1 alpha in monocytes associated with inflammation and cinod
2) Confidence 0.72 Published 1991 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2026474 Disease Relevance 0.09 Pain Relevance 0.13
Other NSAIDs may also inhibit IL1 synthesis or release, but probably do not have a beneficial effect on chondrocyte synthetic activity as they have toxic effects on cartilage metabolism.
Localization (release) of IL1 in chondrocyte associated with cinod
3) Confidence 0.70 Published 1999 Journal Z Rheumatol Section Abstract Doc Link 10441838 Disease Relevance 0.39 Pain Relevance 0.69
Additionally cytokines, such as interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are co-localized to senile plaques, a neuropathological hallmark of AD.
Localization (localized) of IL-1alpha in plaques associated with disease, amyloid plaque and cytokine
4) Confidence 0.68 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399113 Disease Relevance 0.78 Pain Relevance 0.52
Additionally cytokines, such as interleukin-1alpha (IL-1alpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) are co-localized to senile plaques, a neuropathological hallmark of AD.
Localization (localized) of interleukin-1alpha in plaques associated with disease, amyloid plaque and cytokine
5) Confidence 0.68 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12399113 Disease Relevance 0.79 Pain Relevance 0.52
Recombinant interleukin 1 and tumor necrosis factor acting in synergy to release thromboxane, 6-KETO-PGF1 alpha and PGE2 by human neutrophils.
Localization (release) of interleukin 1 in neutrophils associated with necrosis and cancer
6) Confidence 0.64 Published 1988 Journal Scand. J. Rheumatol. Suppl. Section Title Doc Link 3266363 Disease Relevance 0.36 Pain Relevance 0.06
The liberation of interleukin-1 alpha and arachidonic acid from human keratinocytes has been used as an in vitro parameter of irritancy.
Localization (liberation) of interleukin-1 alpha in keratinocytes
7) Confidence 0.62 Published 1995 Journal Toxicol. Lett. Section Abstract Doc Link 8597161 Disease Relevance 0.48 Pain Relevance 0.15
The osteosarcoma cells also secrete IL-1 alpha, IL-1 beta and TNF alpha in the culture medium.
Localization (secrete) of IL-1 alpha associated with osteogenic sarcomas
8) Confidence 0.37 Published 1997 Journal Inflamm. Res. Section Abstract Doc Link 9085144 Disease Relevance 0.39 Pain Relevance 0.23
Interestingly, expression levels of genes encoding secreted proteins from different functional groups including CFI, CC2, NRG1, MMP7, WNT5A, RSOPO2, CSF3R, DPP4, IL1 were deregulated altered in CHM cells compared to the control.
Localization (secreted) of IL1 associated with choroideremia
9) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2793004 Disease Relevance 0.76 Pain Relevance 0.07
Middle ear epithelial cells released IL-1 alpha when stimulated by NTHi components and this cytokine acted in an autocrine/paracrine synergistic manner with NTHi to up-regulate beta-defensin 2.
Localization (released) of IL-1 alpha in epithelial cells associated with hemophilus infection and cytokine
10) Confidence 0.13 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1368979 Disease Relevance 0.77 Pain Relevance 0.21
We demonstrate that IL-1 alpha is secreted by middle ear epithelial cells upon exposure to NTHi components and that it can synergistically act with certain of these molecules to up-regulate beta-defensin 2 via the p38 MAP kinase pathway.



Localization (secreted) of IL-1 alpha in epithelial cells associated with hemophilus infection
11) Confidence 0.13 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1368979 Disease Relevance 0.70 Pain Relevance 0.18
Based on these observations, we investigated if human middle ear epithelial cells could release IL-1 alpha upon exposure to a lysate of NTHi and if this cytokine could have a synergistic effect on beta-defensin 2 up-regulation by the bacterial components.


Localization (release) of IL-1 alpha in epithelial cells associated with hemophilus infection and cytokine
12) Confidence 0.13 Published 2006 Journal BMC Infect Dis Section Abstract Doc Link PMC1368979 Disease Relevance 0.57 Pain Relevance 0.12
Interleukin 1 alpha, interleukin 6, and tumour necrosis factor are all been localised within plaques, and acute phase proteins involved in inflammation, such as amyloid P, alpha-1 antichymotrypsin, and C-reactive protein are also plaque components while immunoglobulin G is located in the plaque corona [14, 40–42].
Localization (localised) of Interleukin 1 alpha in plaque associated with necrosis, inflammation, cancer and alzheimer's dementia
13) Confidence 0.11 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC3018626 Disease Relevance 1.43 Pain Relevance 0.18
For example, excess amounts of bacteria toxins absorbed from the GI mucosa may directly stimulate the release of pro-inflammatory cytokines such as tumour necrosis factor (TNF), interleukin-1 (IL-1) [26], and high mobility group box-1 (HMGB1) protein [27], which could exacerbate inflammatory reactions [23,28,29], but also systemically affect the host's immune system for prolonged periods as non-specific immunostimulants.
Localization (release) of interleukin-1 in immune system associated with necrosis, inflammation, cancer and cytokine
14) Confidence 0.01 Published 2011 Journal Nutr J Section Body Doc Link PMC3022554 Disease Relevance 0.75 Pain Relevance 0.24

General Comments

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