INT191896

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.85
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Prkca) transport (Pbsn) endoplasmic reticulum (Prkca)
enzyme binding (Prkca) protein complex (Prkca) cytoplasm (Prkca)
Anatomy Link Frequency
neuronal 1
astrocytes 1
Pbsn (Mus musculus)
Prkca (Mus musculus)
Pain Link Frequency Relevance Heat
Kinase C 52 100.00 Very High Very High Very High
Calcium channel 2 89.00 High High
Inflammation 8 40.96 Quite Low
cytokine 4 34.84 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Bacterial Infection 2 79.04 Quite High
Apoptosis 4 65.12 Quite High
Injury 40 62.80 Quite High
Death 4 53.88 Quite High
Cancer 8 50.00 Quite Low
Necrosis 6 50.00 Quite Low
INFLAMMATION 8 40.96 Quite Low
Sepsis 6 21.16 Low Low
Hepatotoxicity 2 13.12 Low Low
Disease 10 10.04 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the cellular target of Pb is still elusive, exposure to Pb activates protein kinase C (PKC) in several types of cells, such as astrocytes and neuronal cells in the brain (Costa 1998; Markovac and Goldstein 1988).
Pb Positive_regulation (activates) of PKC in astrocytes associated with kinase c
1) Confidence 0.04 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0.43 Pain Relevance 0.22
Although the cellular target of Pb is still elusive, exposure to Pb activates protein kinase C (PKC) in several types of cells, such as astrocytes and neuronal cells in the brain (Costa 1998; Markovac and Goldstein 1988).
Pb Positive_regulation (activates) of PKC in neuronal associated with kinase c
2) Confidence 0.01 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440772 Disease Relevance 0.43 Pain Relevance 0.22

General Comments

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