INT19190

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Context Info
Confidence 0.50
First Reported 1991
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 14
Total Number 17
Disease Relevance 8.71
Pain Relevance 4.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
monocytes 8
blood 4
macrophages 2
leukocyte 2
paw 2
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 159 100.00 Very High Very High Very High
cytokine 73 100.00 Very High Very High Very High
cINOD 11 100.00 Very High Very High Very High
dexamethasone 47 98.72 Very High Very High Very High
Kinase C 6 98.72 Very High Very High Very High
metalloproteinase 1 98.54 Very High Very High Very High
lidocaine 5 97.08 Very High Very High Very High
Pain 8 93.72 High High
rheumatoid arthritis 15 92.32 High High
cerebral cortex 4 84.24 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 183 100.00 Very High Very High Very High
Necrosis 12 100.00 Very High Very High Very High
Cancer 12 100.00 Very High Very High Very High
Apoptosis 4 100.00 Very High Very High Very High
Disease 121 99.74 Very High Very High Very High
Syndrome 117 99.38 Very High Very High Very High
Adhesions 4 99.24 Very High Very High Very High
Injury 7 98.80 Very High Very High Very High
Targeted Disruption 6 98.60 Very High Very High Very High
Rheumatoid Arthritis 15 98.44 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Heparinized human whole blood was evaluated as a model to study the effects of various classes of anti-inflammatory drugs on IL-1 beta and TNF-alpha release from leukocytes.
Regulation (effects) of Localization (release) of IL-1 beta in blood associated with inflammation and cinod
1) Confidence 0.50 Published 1993 Journal Agents Actions Section Abstract Doc Link 8273590 Disease Relevance 0.17 Pain Relevance 0.21
Effects of gammalinolenic acid on interleukin-1 beta and tumor necrosis factor-alpha secretion by stimulated human peripheral blood monocytes: studies in vitro and in vivo.
Regulation (Effects) of Localization (secretion) of interleukin-1 beta in monocytes associated with necrosis and cancer
2) Confidence 0.46 Published 1999 Journal J. Investig. Med. Section Title Doc Link 10361385 Disease Relevance 0.66 Pain Relevance 0.27
Inflammatory and chemoattractant mediators likely promote phagocytosis of trauma-induced cellular debris by macrophages and these cells can continue to secrete IL-1?
Regulation (continue) of Localization (secrete) of IL-1 in macrophages associated with inflammation and injury
3) Confidence 0.44 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2837019 Disease Relevance 0.93 Pain Relevance 0.21
Proteins that are mutated in AIDs mediate the regulation of NFkappaB activation, cell apoptosis, and IL-1beta secretion through cross-regulated and sometimes common signaling pathways.
Regulation (regulation) of Localization (secretion) of IL-1beta associated with apoptosis and disease
4) Confidence 0.44 Published 2008 Journal Best Pract Res Clin Rheumatol Section Abstract Doc Link 19028365 Disease Relevance 1.53 Pain Relevance 0.10
The protein kinase C (PKC) inhibitor, Go6976, also significantly reduced the stimulatory effect of pyocyanin on IL-1beta, and PDBu increased IL-8 release.
Regulation (effect) of Localization (release) of IL-1beta associated with kinase c
5) Confidence 0.44 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.28 Pain Relevance 0.37
The effects of anti-inflammatory and antiallergic drugs on the release of IL-1 beta and TNF-alpha in the human whole blood assay.
Regulation (effects) of Localization (release) of IL-1 beta in blood associated with inflammation
6) Confidence 0.37 Published 1993 Journal Agents Actions Section Title Doc Link 8273590 Disease Relevance 0.19 Pain Relevance 0.22
Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro.
Regulation (effects) of Localization (secretion) of IL-1 in leukocyte
7) Confidence 0.36 Published 1993 Journal Acta Anaesthesiol Scand Section Title Doc Link 8383401 Disease Relevance 0.18 Pain Relevance 0.47
METHODS: We examined the influence of gammalinolenic acid added to cells in vitro and administered orally in vivo on interleukin-1 beta and tumor necrosis factor-alpha secretion from activated human peripheral blood monocytes.
Spec (examined) Regulation (influence) of Localization (secretion) of interleukin-1 beta in monocytes
8) Confidence 0.34 Published 1999 Journal J. Investig. Med. Section Body Doc Link 10361385 Disease Relevance 0.38 Pain Relevance 0
in CAPS, while also demonstrating the effectiveness of targeting IL-1?
Regulation (effectiveness) of Localization (targeting) of IL-1 associated with syndrome
9) Confidence 0.27 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.40 Pain Relevance 0.27
Suppressive effect of anti-rheumatic drugs on interleukin-1 beta release from human peripheral blood monocytes.
Regulation (effect) of Localization (release) of interleukin-1 beta in monocytes
10) Confidence 0.27 Published 1991 Journal Int. J. Immunopharmacol. Section Title Doc Link 2026474 Disease Relevance 0.09 Pain Relevance 0.13
Since 1989, we have provided abundant evidence, based on human, animal, and cell culture studies, that IL-1, synthesized and released by activated microglia, is an important driving force in the transformation of diffuse amyloid deposits into neuritic A?
Regulation (important) of Localization (released) of IL-1 in microglia associated with amyloid plaque
11) Confidence 0.27 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656298 Disease Relevance 0.71 Pain Relevance 0.29
The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.
Regulation (effect) of Localization (release) of IL-1beta associated with dexamethasone
12) Confidence 0.26 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.21 Pain Relevance 0.28
The knockout animals were unimpaired in their ability to produce mRNA for pro-IL-1beta, and cytometric analysis of paw and systemic cytokines from knockout and wild-type animals following adjuvant insult suggests a selective effect of the gene deletion on release of IL-1beta and IL-10, with systemic reductions in adjuvant-induced increases in IL-6 and MCP-1.
Regulation (effect) of Localization (release) of IL-1beta in paw associated with targeted disruption and cytokine
13) Confidence 0.26 Published 2005 Journal Pain Section Abstract Doc Link 15777864 Disease Relevance 1.05 Pain Relevance 0.52
Luminex technology was used to determine the effect of BOL-303242-X on LPS- or IL-1ß-induced cytokine release and intercellular adhesion molecule-1 (ICAM-1) levels.
Spec (determine) Regulation (effect) of Localization (release) of IL-1 associated with adhesions and cytokine
14) Confidence 0.10 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2790480 Disease Relevance 0.46 Pain Relevance 0.41
The role of ATP/P2X receptor signaling in release of IL-1?
Regulation (role) of Localization (release) of IL-1
15) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2906308 Disease Relevance 0.20 Pain Relevance 0.05
Secretion from Primary Human Peripheral Blood Monocytes by P2X7-independent and P2X7-dependent Mechanisms*

The processing and regulated secretion of IL-1?

Regulation (regulated) of Localization (secretion) of IL-1 in Monocytes
16) Confidence 0.05 Published 2010 Journal The Journal of Biological Chemistry Section Title Doc Link PMC2906308 Disease Relevance 0.10 Pain Relevance 0.21
The purpose of this study was to examine whether drugs used in the treatment of arthritic disorders possess any inhibitory potential on the proteoglycanolytic activities of matrix metalloproteinases (MMPs), and to determine whether drugs which inhibit these enzymes also modulate the biosynthesis and release of proteoglycans (PGs) from interleukin-1-(IL-1) treated articular cartilage explants.
Regulation (modulate) of Localization (release) of interleukin-1 in articular cartilage associated with metalloproteinase and arthritis
17) Confidence 0.03 Published 1997 Journal Biochem. Pharmacol. Section Abstract Doc Link 9264315 Disease Relevance 0.15 Pain Relevance 0.10

General Comments

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