INT19191

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Context Info
Confidence 0.58
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 35
Total Number 35
Disease Relevance 15.19
Pain Relevance 13.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL1B) signal transduction (IL1B) extracellular space (IL1B)
aging (IL1B) extracellular region (IL1B) cell-cell signaling (IL1B)
Anatomy Link Frequency
astrocytes 8
monocytes 7
cartilage 4
PBMC 4
macrophages 3
IL1B (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 36 100.00 Very High Very High Very High
COX2 16 100.00 Very High Very High Very High
Inflammatory mediators 9 100.00 Very High Very High Very High
dexamethasone 68 99.98 Very High Very High Very High
Cannabinoid 9 99.98 Very High Very High Very High
Inflammatory response 10 99.80 Very High Very High Very High
rheumatoid arthritis 30 99.70 Very High Very High Very High
lidocaine 10 99.66 Very High Very High Very High
methotrexate 2 99.62 Very High Very High Very High
Calcitonin gene-related peptide 1 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 287 100.00 Very High Very High Very High
Cancer 26 99.80 Very High Very High Very High
Rheumatoid Arthritis 30 99.70 Very High Very High Very High
Necrosis 16 99.56 Very High Very High Very High
Inflammatory Pain 6 99.38 Very High Very High Very High
Pancreatitis 11 97.28 Very High Very High Very High
Anaplastic Astrocytoma 20 97.00 Very High Very High Very High
Granuloma 1 96.64 Very High Very High Very High
Acne 1 95.76 Very High Very High Very High
Arthritis 44 94.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
D-Penicillamine (up to 6 mM), cyclosporin A (up to 1 microM) and methotrexate (up to 12 microM) inhibited neither cell-associated nor secreted IL-1 beta levels.
Negative_regulation (inhibited) of Localization (secreted) of IL-1 beta associated with methotrexate
1) Confidence 0.58 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.09 Pain Relevance 0.27
The ATP-induced release and maturation of IL-1 beta from human monocytes and macrophages, therefore, was suppressed by anion transport inhibitors, suggesting that anion conductance is a necessary component of the ATP-promoted externalization mechanism.
Negative_regulation (suppressed) of Localization (release) of IL-1 in macrophages
2) Confidence 0.58 Published 1994 Journal J. Immunol. Section Abstract Doc Link 8051418 Disease Relevance 0.21 Pain Relevance 0.30
A second effect of SKF86002 was to inhibit release of IL-1 beta into the medium in response to high concentrations of LPS; this effect is observed only with freshly isolated human monocytes as other IL-1 beta-producing cells do not release significant cytokine in response to LPS.
Negative_regulation (inhibit) of Localization (release) of IL-1 in monocytes associated with cytokine
3) Confidence 0.57 Published 1995 Journal Mol. Pharmacol. Section Abstract Doc Link 7565623 Disease Relevance 0 Pain Relevance 0.23
The stimulatory effect of pyocyanin on the IL-1beta- or PDBu-stimulated IL-8 release was reduced in the presence of dexamethasone, budesonide, and fluticasone.
Negative_regulation (reduced) of Localization (release) of IL-1beta associated with dexamethasone
4) Confidence 0.57 Published 2006 Journal Respir Med Section Abstract Doc Link 16448811 Disease Relevance 0.26 Pain Relevance 0.28
These data demonstrate that selective blockade of P2X7 receptors in vivo produces significant antinociception in animal models of inflammatory pain and suggest that the antihyperalgesic effects of P2X7 receptor blockade in an inflammatory pain model in mice are mediated by blocking the release of IL-1beta.
Negative_regulation (blocking) of Localization (release) of IL-1beta associated with antihyperalgesic, antinociception and ipn
5) Confidence 0.57 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19464323 Disease Relevance 0.63 Pain Relevance 0.88
Both diclofenac and indomethacin potently inhibited IL-1 alpha-induced PGE2 release, with IC50 values of 1.6 +/- 0.02 nM and 5.5 +/- 0.1 nM, respectively.
Negative_regulation (inhibited) of Localization (release) of IL-1 associated with diclofenac
6) Confidence 0.43 Published 1989 Journal Biochem. Pharmacol. Section Abstract Doc Link 2512925 Disease Relevance 0.09 Pain Relevance 0.22
These results suggest a possible immunotherapeutic effectiveness of some anti-rheumatic drugs on rheumatoid arthritis through their inhibition of IL-1 beta release.
Negative_regulation (inhibition) of Localization (release) of IL-1 beta associated with rheumatoid arthritis
7) Confidence 0.43 Published 1991 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2026474 Disease Relevance 0.19 Pain Relevance 0.14
Anti-rheumatic drugs including Auranofin and Sulphasalazine suppressed IL-1 beta release significantly at therapeutic concentrations, whereas Bucillamine, Lobenzarit, D-Penicillamine and Ibuprofen did not.
Negative_regulation (suppressed) of Localization (release) of IL-1 beta
8) Confidence 0.43 Published 1991 Journal Int. J. Immunopharmacol. Section Abstract Doc Link 2026474 Disease Relevance 0.10 Pain Relevance 0.14
Nordihydroguaiaretic acid inhibited the level of the secreted form of IL-1 beta, but tended to increase the cell-associated level.
Negative_regulation (inhibited) of Localization (secreted) of IL-1 beta
9) Confidence 0.43 Published 1989 Journal Drugs Exp Clin Res Section Abstract Doc Link 2513175 Disease Relevance 0.21 Pain Relevance 0.28
A less marked effect of the drug was noted under LPS treatment, and inhibition of the production/secretion of IL-1 beta was found only at pharmacological concentration.
Negative_regulation (inhibition) of Localization (production/secretion) of IL-1 beta
10) Confidence 0.43 Published 1993 Journal Agents Actions Suppl. Section Abstract Doc Link 8456629 Disease Relevance 0.32 Pain Relevance 0.47
In the absence of LPS and at therapeutic concentration, tiaprofenic acid decreased both the synthesis and release of IL-1 beta.
Negative_regulation (decreased) of Localization (release) of IL-1 beta
11) Confidence 0.43 Published 1993 Journal Agents Actions Suppl. Section Abstract Doc Link 8456629 Disease Relevance 0.34 Pain Relevance 0.50
A-839977 also potently blocked agonist-evoked YO-PRO uptake and IL-1beta release from differentiated human THP-1 cells.
Negative_regulation (blocked) of Localization (release) of IL-1beta in THP-1 associated with agonist
12) Confidence 0.42 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19464323 Disease Relevance 0.75 Pain Relevance 0.89
We conclude that brief ischemia of remote preconditioning such as heart or liver protects gastric mucosa against severe ischemia-reperfusion-induced gastric lesions as effectively as local preconditioning of the stomach itself via the mechanism involving prostaglandin derived from cyclooxygenase-1 and cyclooxygenase-2 and the activation of sensory nerves releasing calcitonin gene-related peptide (CGRP) combined with the suppression of interleukin-1beta and TNF-alpha expression and release.
Negative_regulation (suppression) of Localization (release) of interleukin-1beta in stomach associated with ischemia and calcitonin gene-related peptide
13) Confidence 0.42 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363968 Disease Relevance 0.64 Pain Relevance 0.35
Although donor and CP PBMC responded equally to LPS, PACAP-mediated counteraction of LPS-induced cytokine response was switched from inhibiting TNF-alpha to decreasing IL-1beta and increasing IL-10 secretion.
Negative_regulation (decreasing) of Localization (secretion) of IL-1beta in PBMC associated with chronic pancreatitis and cytokine
14) Confidence 0.42 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17962362 Disease Relevance 1.12 Pain Relevance 0.99
Our results demonstrated that exposing LPS-stimulated human monocytes to NCX-4016 resulted in a 40-80% inhibition of IL-1beta, IL-8, IL-12, IL-18, IFN-gamma, and TNF-alpha release with an EC(50) of 10-20 microM for IL-1beta and IL-18.
Negative_regulation (inhibition) of Localization (release) of IL-1beta in monocytes
15) Confidence 0.41 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.24 Pain Relevance 0.38
IL-18 immunoneutralization resulted in a 60-80% reduction of IL-1beta, IL-8, IFN-gamma, and TNF-alpha release from LPS-stimulated monocytes.
Negative_regulation (reduction) of Localization (release) of IL-1beta in monocytes
16) Confidence 0.41 Published 2000 Journal J. Immunol. Section Abstract Doc Link 11046058 Disease Relevance 0.15 Pain Relevance 0.31
CC-4047 does not, however, block COX2 induction in or prostacyclin secretion from IL-1beta stimulated human umbilical vein endothelial cells (HUVEC) cells, nor does it inhibit COX1 in either monocytes or HUVEC cells.
Negative_regulation (block) of Localization (secretion) of IL-1beta in endothelial cells associated with cox2 and cox1
17) Confidence 0.41 Published 2007 Journal J. Clin. Immunol. Section Abstract Doc Link 17308870 Disease Relevance 0.51 Pain Relevance 0.90
and responded as seen previously to rosiglitazone, LG268, and IL-1?
Negative_regulation (previously) of Localization (seen) of IL-1
18) Confidence 0.41 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
As previously reported, the 5-lipoxygenase/cyclooxygenase (5-LO/CO) inhibitor, SKF86002 (30 microM), significantly inhibited both IL-1 beta and TNF-alpha release using either stimulus.
Negative_regulation (inhibited) of Localization (release) of IL-1 beta
19) Confidence 0.35 Published 1993 Journal Agents Actions Section Abstract Doc Link 8273590 Disease Relevance 0.16 Pain Relevance 0.21
Both lidocaine and bupivacaine inhibited the release of the inflammatory mediators leukotriene B4 (LTB4) and interleukin-1 (IL-1) evaluated by radioimmunoassay (RIA).
Negative_regulation (inhibited) of Localization (release) of IL-1 associated with inflammatory mediators and lidocaine
20) Confidence 0.34 Published 1993 Journal Acta Anaesthesiol Scand Section Abstract Doc Link 8383401 Disease Relevance 0.18 Pain Relevance 0.50

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