INT191926

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 17.68
Pain Relevance 0.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lepr) extracellular space (Lepr) extracellular region (Lepr)
plasma membrane (Lepr)
Lepr (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 91 99.48 Very High Very High Very High
tolerance 111 92.88 High High
Neuropeptide 3 87.52 High High
Bile 8 85.40 High High
amygdala 8 75.44 Quite High
Inflammatory marker 5 69.04 Quite High
cytokine 53 62.68 Quite High
Inflammatory mediators 1 58.20 Quite High
medulla 27 56.64 Quite High
Thalamus 2 54.24 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 3907 100.00 Very High Very High Very High
Albuminuria 92 99.84 Very High Very High Very High
Coronary Artery Disease 139 99.82 Very High Very High Very High
INFLAMMATION 96 99.48 Very High Very High Very High
Gestational Diabetes 105 99.40 Very High Very High Very High
Obesity 231 99.16 Very High Very High Very High
Autoimmune Disease 31 98.92 Very High Very High Very High
Syndrome 32 98.20 Very High Very High Very High
Atherosclerosis 19 98.20 Very High Very High Very High
Weight Loss 163 97.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
U22421, mouse (Mus musculus); http://www.ncbi.nlm.gov]; db/db mice, which lack the leptin receptor isoform 1 gene [lepr; GenBank accession no.
Negative_regulation (lack) of lepr
1) Confidence 0.48 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 1.85 Pain Relevance 0.08
U22421, mouse (Mus musculus); http://www.ncbi.nlm.gov]; db/db mice, which lack the leptin receptor isoform 1 gene [lepr; GenBank accession no.
Negative_regulation (lack) of leptin receptor isoform 1 gene
2) Confidence 0.40 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440793 Disease Relevance 1.85 Pain Relevance 0.07
These include deficiencies of leptin, LEPRB, single-minded 1 (SIM1), PC1, POMC and MC4R deficiency [184].
Negative_regulation (deficiencies) of LEPRB
3) Confidence 0.31 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.84 Pain Relevance 0.16
Studies performed with mice lacking AQP9 and leptin receptor function, developed obese mice, with type II diabetes and increased lipolysis and glycerol production [82].
Negative_regulation (lacking) of leptin receptor associated with diabetes mellitus and obesity
4) Confidence 0.05 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923373 Disease Relevance 0.70 Pain Relevance 0.04
In contrast, 90% of control mice developed diabetes by 100 days after Cy bolus.
Negative_regulation (developed) of diabetes associated with diabetes mellitus
5) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2950856 Disease Relevance 1.10 Pain Relevance 0.12
Based on our and previous studies it can be speculated, that the low grade inflammation seen in both IHD and T2D declines in diabetes, when diabetic patients develop symptomatic atherosclerosis, and therefore make hsCRP as a biomarker of IHD in diabetic patients questionable.
Negative_regulation (declines) of diabetes associated with coronary artery disease, inflammation, atherosclerosis and diabetes mellitus
6) Confidence 0.01 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3016330 Disease Relevance 2.77 Pain Relevance 0.19
The export summary file provides dbSNP accession numbers, functional type and consequence, gene accession description information, GO terms, and OMIM description (if available) for each SNP.
Negative_regulation (numbers) of dbSNP
7) Confidence 0.01 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1797019 Disease Relevance 0.05 Pain Relevance 0
Furthermore, regular exercise may prevent type 2 diabetes in high-risk individuals (11–13).
Spec (may) Negative_regulation (prevent) of diabetes associated with diabetes mellitus
8) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.71 Pain Relevance 0
MNT is an integral component of diabetes prevention, management, and self-management education.
Negative_regulation (prevention) of diabetes associated with diabetes mellitus
9) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 0.89 Pain Relevance 0
Information on the National Diabetes Education Program (NDEP) campaign to prevent type 2 diabetes in women with GDM can be found at http://ndep.nih.gov/media/NeverTooEarly_Tipsheet.pdf.


Negative_regulation (prevent) of diabetes associated with gestational diabetes and diabetes mellitus
10) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 1.50 Pain Relevance 0.04
Clinical studies are being conducted to test various methods of preventing type 1 diabetes or reversing early type 1 diabetes in those with evidence of autoimmunity.


Negative_regulation (reversing) of diabetes associated with autoimmune disease and diabetes mellitus
11) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 1.46 Pain Relevance 0
Clinical studies are being conducted to test various methods of preventing type 1 diabetes or reversing early type 1 diabetes in those with evidence of autoimmunity.


Negative_regulation (preventing) of diabetes associated with autoimmune disease and diabetes mellitus
12) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 1.45 Pain Relevance 0
For other drugs, the issues of cost, side effects, and lack of persistence of effect in some studies led the panel to not recommend use for diabetes prevention.
Negative_regulation (prevention) of diabetes associated with diabetes mellitus
13) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 1.36 Pain Relevance 0.09
The more recent Veterans Affairs Diabetes Trial (VADT) in type 2 diabetes also showed significant reductions in albuminuria with intensive (achieved median A1C 6.9%) compared with standard glycemic control but no difference in retinopathy and neuropathy (60,61).
Negative_regulation (reductions) of diabetes associated with diabetes mellitus, neuropathic pain, ocular toxicity (including many sub-types) and albuminuria
14) Confidence 0.00 Published 2010 Journal Diabetes Care Section Body Doc Link PMC2797382 Disease Relevance 1.14 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox