INT191952

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Context Info
Confidence 0.11
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 3.31
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB2) extracellular matrix organization (NFKB2) DNA binding (NFKB2)
cytoplasm (NFKB2) cytosol (NFKB2) signal transduction (NFKB2)
Anatomy Link Frequency
chondrocytes 2
muscle 2
NFKB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 26 99.52 Very High Very High Very High
Inflammatory response 6 92.72 High High
rheumatoid arthritis 2 90.32 High High
Pain 5 89.24 High High
cytokine 15 78.08 Quite High
Osteoarthritis 66 75.96 Quite High
antagonist 4 73.72 Quite High
Arthritis 15 71.44 Quite High
Bile 2 27.44 Quite Low
depression 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 32 99.52 Very High Very High Very High
Mesothelioma 47 99.10 Very High Very High Very High
Frailty 3 95.32 Very High Very High Very High
Appetite Loss 90 90.88 High High
Rheumatoid Arthritis 2 90.32 High High
Pain 5 89.24 High High
Dyspnea 2 88.92 High High
Disease 30 87.88 High High
Congenital Anomalies 11 85.08 High High
Osteoarthritis 66 75.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The primary endpoint is overall survival.In preclinical mesothelioma models, the proteasome inhibitor bortezomib inhibits constitutive activation of NFkB and enhances the cytotoxicity of cisplatin and pemetrexed [49, 50].
Negative_regulation (inhibits) of Positive_regulation (activation) of NFkB associated with mesothelioma
1) Confidence 0.11 Published 2008 Journal Curr Treat Options Oncol Section Body Doc Link PMC2782121 Disease Relevance 0.88 Pain Relevance 0.09
effects) [37-39] GS was also shown, on chondrocytes, to directly inhibit the activation of the transcription factor nuclear factor-kappa B[38,39], thus preventing the activation of a gene required for osteoclastogenesis.
Negative_regulation (inhibit) of Positive_regulation (activation) of nuclear factor-kappa B in chondrocytes
2) Confidence 0.09 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246236 Disease Relevance 0.13 Pain Relevance 0.08
Thus, whole plant yucca powder has powerful anti-inflammatory activity, mediated via inhibition of NFkB activation.
Negative_regulation (inhibition) of Positive_regulation (activation) of NFkB associated with inflammation
3) Confidence 0.09 Published 2006 Journal J Inflamm (Lond) Section Body Doc Link PMC1440857 Disease Relevance 0.95 Pain Relevance 0.47
Several recent laboratory studies have shown that n-3 fatty acid may attenuate protein degradation, potentially by preventing NFkB accumulation in the nucleus, preventing the degradation of muscle proteins.
Negative_regulation (preventing) of Positive_regulation (accumulation) of NFkB in muscle
4) Confidence 0.08 Published 2010 Journal Curr Treat Options Oncol Section Abstract Doc Link PMC3016925 Disease Relevance 1.35 Pain Relevance 0.12

General Comments

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