INT191968

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2011
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 15
Disease Relevance 7.14
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
brain 6
liver 5
muscle 3
pancreatic islets 2
blood 2
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 122 85.52 High High
Hippocampus 12 76.16 Quite High
metalloproteinase 40 69.56 Quite High
Parenteral administration 2 66.56 Quite High
Inflammation 52 65.04 Quite High
vagus nerve 2 58.56 Quite High
withdrawal 1 36.68 Quite Low
imagery 5 27.56 Quite Low
cINOD 23 5.00 Very Low Very Low Very Low
substance P 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 267 100.00 Very High Very High Very High
Alzheimer's Dementia 152 100.00 Very High Very High Very High
Disease 326 99.72 Very High Very High Very High
Diabetes Mellitus 115 97.20 Very High Very High Very High
Impaired Glucose Tolerance 94 85.52 High High
Amyloid Plaque 26 79.76 Quite High
Natriuresis 1 78.32 Quite High
Sprains And Strains 198 75.04 Quite High
Body Weight 30 70.96 Quite High
INFLAMMATION 55 65.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, the overexpression of IDE in transgenic mice results in drastically reduced brain A?
Negative_regulation (results) of Gene_expression (overexpression) of IDE in brain associated with targeted disruption
1) Confidence 0.39 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.61 Pain Relevance 0.06
In our experiment, blood glucose levels were not affected with lower doses of insulin (2 ?
Negative_regulation (lower) of Gene_expression (doses) of insulin in blood
2) Confidence 0.36 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.06
Charcoal meal was administered (i.g) 30 min after insulin administration and SIT was determined after 50 min.
Spec (determined) Negative_regulation (determined) of Gene_expression (administration) of insulin
3) Confidence 0.36 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.12 Pain Relevance 0
It has been shown in animal models that reduction in both neprilysin and IDE expression in the brain correlated with increased A?
Negative_regulation (reduction) of Gene_expression (expression) of IDE in brain
4) Confidence 0.29 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2726140 Disease Relevance 0.62 Pain Relevance 0
Once expression of IDE and NEP is reduced in the AD brain leading to A?
Negative_regulation (reduced) of Gene_expression (expression) of IDE in brain associated with disease
5) Confidence 0.25 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2726140 Disease Relevance 0.91 Pain Relevance 0.04
Each individual peak (a–h, see Figure 2C) from the T40/IDE digest also reduced the A?
Negative_regulation (reduced) of Gene_expression (digest) of T40/IDE
6) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0
IDE has been proposed to be an amyloid scavenger recognizing structural ?
Negative_regulation (scavenger) of Gene_expression (proposed) of IDE associated with alzheimer's dementia
7) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.28 Pain Relevance 0
Pancreas morphology and insulin content, and insulin secretion in isolated pancreatic islets
Negative_regulation (morphology) of Gene_expression (content) of insulin in pancreatic islets
8) Confidence 0.25 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.36 Pain Relevance 0.07
loss in insulin-sensitive tissues, such as the liver, or whether the insulin sensitization is a consequence of the functional loss of GSK-3?
Negative_regulation (loss) of Gene_expression (tissues) of insulin-sensitive in liver
9) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.98 Pain Relevance 0.06
loss in insulin-sensitive tissues, such as the liver, or whether the insulin sensitization is a consequence of the functional loss of GSK-3?
Negative_regulation (loss) of Gene_expression (sensitization) of insulin in liver
10) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.06 Pain Relevance 0.06
The data from these studies support the idea that there are isoform and tissue-specific roles for GSK-3 in the regulation of glucose metabolism and insulin action, such that GSK-3?
Negative_regulation (metabolism) of Gene_expression (action) of insulin
11) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.78 Pain Relevance 0.08
Since there was a lack of insulin-sensitization in the tissue-specific deletions of GSK-3?
Negative_regulation (lack) of Gene_expression (deletions) of insulin
12) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.29 Pain Relevance 0
In addition, the extent of insulin- and glucose-induced dephosphorylation and activation of GS in muscle and liver tissues was comparable in Alb Cre + and Alb Cre – mice (Figures 6A and 6B) and the amount of glycogen deposited within in these tissues was also unaffected by the loss of hepatic GSK-3?
Negative_regulation (comparable) of Gene_expression (extent) of insulin in muscle
13) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.32 Pain Relevance 0
In addition, the extent of insulin- and glucose-induced dephosphorylation and activation of GS in muscle and liver tissues was comparable in Alb Cre + and Alb Cre – mice (Figures 6A and 6B) and the amount of glycogen deposited within in these tissues was also unaffected by the loss of hepatic GSK-3?
Negative_regulation (comparable) of in liver Gene_expression (extent) of insulin in muscle
14) Confidence 0.06 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.32 Pain Relevance 0
DHA may also increase levels of insulin-degrading enzyme and A?
Negative_regulation (levels) of Gene_expression (enzyme) of insulin-degrading
15) Confidence 0.02 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.51 Pain Relevance 0.03

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