INT191968

Context Info Confidence 0.39 First Reported 2005 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 9 Total Number 15 Disease Relevance 7.14 Pain Relevance 0.47

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide) ATPase activity (Ide) nucleus (Ide)

Anatomy Link Frequency brain 6 liver 5 muscle 3 pancreatic islets 2 blood 2 Ide (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 122 85.52 Hippocampus 12 76.16 metalloproteinase 40 69.56 Parenteral administration 2 66.56 Inflammation 52 65.04 vagus nerve 2 58.56 withdrawal 1 36.68 imagery 5 27.56 cINOD 23 5.00 substance P 11 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 267 100.00 Alzheimer's Dementia 152 100.00 Disease 326 99.72 Diabetes Mellitus 115 97.20 Impaired Glucose Tolerance 94 85.52 Amyloid Plaque 26 79.76 Natriuresis 1 78.32 Sprains And Strains 198 75.04 Body Weight 30 70.96 INFLAMMATION 55 65.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Conversely, the overexpression of IDE in transgenic mice results in drastically reduced brain A?

Negative_regulation (results) of Gene_expression (overexpression) of IDE in brain associated with targeted disruption

1) Confidence 0.39 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.61 Pain Relevance 0.06

In our experiment, blood glucose levels were not affected with lower doses of insulin (2 ?

Negative_regulation (lower) of Gene_expression (doses) of insulin in blood

2) Confidence 0.36 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.06

Charcoal meal was administered (i.g) 30 min after insulin administration and SIT was determined after 50 min.

Spec (determined) Negative_regulation (determined) of Gene_expression (administration) of insulin

3) Confidence 0.36 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.12 Pain Relevance 0

It has been shown in animal models that reduction in both neprilysin and IDE expression in the brain correlated with increased A?

Negative_regulation (reduction) of Gene_expression (expression) of IDE in brain

4) Confidence 0.29 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2726140 Disease Relevance 0.62 Pain Relevance 0

Once expression of IDE and NEP is reduced in the AD brain leading to A?

Negative_regulation (reduced) of Gene_expression (expression) of IDE in brain associated with disease

5) Confidence 0.25 Published 2009 Journal Mol Neurodegener Section Body Doc Link PMC2726140 Disease Relevance 0.91 Pain Relevance 0.04

Each individual peak (a–h, see Figure 2C) from the T40/IDE digest also reduced the A?

Negative_regulation (reduced) of Gene_expression (digest) of T40/IDE

6) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0

IDE has been proposed to be an amyloid scavenger recognizing structural ?

Negative_regulation (scavenger) of Gene_expression (proposed) of IDE associated with alzheimer's dementia

7) Confidence 0.25 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.28 Pain Relevance 0

Pancreas morphology and insulin content, and insulin secretion in isolated pancreatic islets

Negative_regulation (morphology) of Gene_expression (content) of insulin in pancreatic islets

8) Confidence 0.25 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.36 Pain Relevance 0.07

loss in insulin-sensitive tissues, such as the liver, or whether the insulin sensitization is a consequence of the functional loss of GSK-3?

Negative_regulation (loss) of Gene_expression (tissues) of insulin-sensitive in liver

9) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.98 Pain Relevance 0.06

loss in insulin-sensitive tissues, such as the liver, or whether the insulin sensitization is a consequence of the functional loss of GSK-3?

Negative_regulation (loss) of Gene_expression (sensitization) of insulin in liver

10) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.06 Pain Relevance 0.06

The data from these studies support the idea that there are isoform and tissue-specific roles for GSK-3 in the regulation of glucose metabolism and insulin action, such that GSK-3?

Negative_regulation (metabolism) of Gene_expression (action) of insulin

11) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.78 Pain Relevance 0.08

Since there was a lack of insulin-sensitization in the tissue-specific deletions of GSK-3?

Negative_regulation (lack) of Gene_expression (deletions) of insulin

12) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.29 Pain Relevance 0

In addition, the extent of insulin- and glucose-induced dephosphorylation and activation of GS in muscle and liver tissues was comparable in Alb Cre + and Alb Cre – mice (Figures 6A and 6B) and the amount of glycogen deposited within in these tissues was also unaffected by the loss of hepatic GSK-3?

Negative_regulation (comparable) of Gene_expression (extent) of insulin in muscle

13) Confidence 0.16 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.32 Pain Relevance 0

In addition, the extent of insulin- and glucose-induced dephosphorylation and activation of GS in muscle and liver tissues was comparable in Alb Cre + and Alb Cre – mice (Figures 6A and 6B) and the amount of glycogen deposited within in these tissues was also unaffected by the loss of hepatic GSK-3?

Negative_regulation (comparable) of in liver Gene_expression (extent) of insulin in muscle

14) Confidence 0.06 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.32 Pain Relevance 0

DHA may also increase levels of insulin-degrading enzyme and A?

Negative_regulation (levels) of Gene_expression (enzyme) of insulin-degrading

15) Confidence 0.02 Published 2010 Journal Mol Neurobiol Section Body Doc Link PMC2876259 Disease Relevance 0.51 Pain Relevance 0.03

General Comments

This test has worked.