INT191970

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Context Info
Confidence 0.51
First Reported 2005
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 29
Total Number 33
Disease Relevance 12.94
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
liver 3
blood 3
fat 3
pancreas 2
body 2
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
alcohol 14 100.00 Very High Very High Very High
tolerance 162 99.90 Very High Very High Very High
fibrosis 1 89.00 High High
Hippocampus 34 88.72 High High
Neuropeptide 4 86.08 High High
substance P 16 85.36 High High
Neurotransmitter 3 85.28 High High
cytokine 6 83.32 Quite High
antagonist 22 80.72 Quite High
Central nervous system 16 80.68 Quite High
Disease Link Frequency Relevance Heat
Insulin Resistance 41 100.00 Very High Very High Very High
Hyperinsulinism 30 100.00 Very High Very High Very High
Impaired Glucose Tolerance 127 99.90 Very High Very High Very High
Diabetes Mellitus 412 99.36 Very High Very High Very High
Severe Combined Immunodeficiency 37 99.24 Very High Very High Very High
Targeted Disruption 306 99.10 Very High Very High Very High
Metabolic Syndrome 20 98.04 Very High Very High Very High
Sprains And Strains 175 97.76 Very High Very High Very High
Obesity 166 97.20 Very High Very High Very High
Body Weight 71 96.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The elevated serum insulin levels observed with higher doses of insulin might be due to insulin administration itself or a reflex release of endogenous insulin from the pancreas.
Positive_regulation (elevated) of insulin in pancreas
1) Confidence 0.51 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.07 Pain Relevance 0
Moreover, these observations were recorded at higher concentrations of insulin [14,18,20].
Positive_regulation (concentrations) of insulin
2) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
Our subsidiary experiment about in vitro effect of insulin on mouse ileal longitudinal smooth muscle indicated that all the dose ranges of insulin (2, 20, 200 ?
Positive_regulation (ranges) of insulin in smooth muscle
3) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
These findings indicate that exogenously administered insulin is solely responsible for significant acceleration of SIT, but with the higher doses of insulin elevated endogenous insulin levels produced cannot be ruled out in acceleration of SIT.
Positive_regulation (elevated) of insulin
4) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.06 Pain Relevance 0
Normally the C-peptide level is expected to come down by supplementation of insulin.
Positive_regulation (supplementation) of insulin
5) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.14 Pain Relevance 0
It is worthy of note that the increase in insulin level was evident under basal conditions (4 h post-prandial), but not after an overnight fast or even under dynamic stimulated conditions.
Positive_regulation (increase) of insulin
6) Confidence 0.40 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.27 Pain Relevance 0.09
Further, the 2 m and 2 U doses of insulin significantly elevated serum insulin and C-peptide levels.


Positive_regulation (elevated) of insulin
7) Confidence 0.39 Published 2006 Journal BMC Pharmacol Section Abstract Doc Link PMC1444921 Disease Relevance 0.33 Pain Relevance 0
These findings indicate that exogenously administered insulin is solely responsible for significant acceleration of SIT, but with the higher doses of insulin elevated endogenous insulin levels produced cannot be ruled out in acceleration of SIT.
Positive_regulation (elevated) of insulin
8) Confidence 0.39 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.07 Pain Relevance 0
The elevated serum insulin levels observed with higher doses of insulin might be due to insulin administration itself or a reflex release of endogenous insulin from the pancreas.
Positive_regulation (elevated) of insulin in pancreas
9) Confidence 0.37 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.07 Pain Relevance 0
But with the higher doses of insulin (2 m and 2 U/kg), the serum insulin levels were significantly elevated (P < 0.01) (Fig 3).
Positive_regulation (elevated) of insulin
10) Confidence 0.34 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
Moreover, the total T40/IDE digest also increased the apparent rate of fibril formation (from 48±15 for A?
Positive_regulation (total) of T40/IDE
11) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0
When applied to three independent T40/IDE digests of 30 min, analysis of the CD spectra by deconvolution showed large and unambiguous changes with a decrease in ?
Neg (independent) Positive_regulation (independent) of T40/IDE
12) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.06 Pain Relevance 0
Along with IDE, NEP is an important A?
Positive_regulation (important) of IDE
13) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0 Pain Relevance 0.04
While the CSR peptides themselves may offer a potential target in the struggle to prevent abnormal protein aggregation in the brain, our results suggest that simply increasing IDE and NEP activity may not be as beneficial as anticipated.
Positive_regulation (increasing) of IDE in brain
14) Confidence 0.27 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.35 Pain Relevance 0
does not result in increased insulin sensitivity.
Neg (not) Positive_regulation (increased) of insulin associated with hyperinsulinism
15) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.29 Pain Relevance 0
knockout (KO) animals are viable and fertile and exhibit enhanced insulin sensitivity and glucose tolerance, accompanied by elevated hepatic glycogen deposition [11].
Positive_regulation (enhanced) of insulin associated with targeted disruption, tolerance and impaired glucose tolerance
16) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.99 Pain Relevance 0.08
in all tissues (global KO) display improved whole body glucose and insulin tolerance and enhanced hepatic glycogen storage and insulin signaling [11].
Positive_regulation (enhanced) of insulin in body associated with targeted disruption and tolerance
17) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.52 Pain Relevance 0.10
reported here, we postulate that enhanced neuronal insulin signaling may contribute to the improved metabolic and liver-specific phenotype observed in the global GSK-3?
Positive_regulation (enhanced) of insulin in liver
18) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.20 Pain Relevance 0.03
The tissues responsible for the improved glucose tolerance and enhanced hepatic insulin signaling are currently unknown.
Positive_regulation (enhanced) of insulin associated with tolerance and impaired glucose tolerance
19) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 1.15 Pain Relevance 0.08
After the mice were orally administered with corn silk extract, the blood glucose and the HbA1c were significantly decreased in alloxan-induced hyperglycemic mice (p < 0.05, p < 0.01, respectively), while the level of insulin secretionn was markedly elevated in alloxa-induced hyperglycemic mice (p < 0.05).
Positive_regulation (elevated) of insulin in blood
20) Confidence 0.14 Published 2009 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2785813 Disease Relevance 0.08 Pain Relevance 0

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