INT191971

Context Info Confidence 0.45 First Reported 2006 Last Reported 2011 Negated 4 Speculated 1 Reported most in Body Documents 5 Total Number 6 Disease Relevance 1.97 Pain Relevance 0.20

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide) ATPase activity (Ide) nucleus (Ide)

Anatomy Link Frequency blood 2 Ide (Mus musculus)

Pain Link Frequency Relevance Heat tolerance 32 84.36 Parenteral administration 3 67.12 vagus nerve 3 59.20 cINOD 5 5.00 nMDA receptor 3 5.00 peripheral neuropathy 3 5.00 antagonist 3 5.00 Nerve growth factor 3 5.00 Neurotransmitter 3 5.00 abdominal pain 3 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 58 99.78 Disease 134 99.56 Insulin Resistance 7 96.44 Diabetes Mellitus 88 91.52 Impaired Glucose Tolerance 23 84.36 Amyloid Plaque 9 79.56 Hyperinsulinism 4 79.24 Apoptosis 1 63.44 Obesity 38 61.16 Sprains And Strains 34 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

We observed that serum insulin levels were not altered with the lowest dose of insulin (2 ?

Neg (not) Regulation (altered) of Gene_expression (levels) of insulin

1) Confidence 0.45 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03

We observed that serum insulin levels were not altered with the lowest dose of insulin (2 ?

Neg (not) Regulation (altered) of Gene_expression (dose) of insulin

2) Confidence 0.38 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03

In our experiment, blood glucose levels were not affected with lower doses of insulin (2 ?

Neg (not) Regulation (affected) of Gene_expression (doses) of insulin in blood

3) Confidence 0.38 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.06

A study using AD transgenic mice that had an over expression of IDE or NEP demonstrated a significant reduction in A?

Regulation (had) of Gene_expression (expression) of IDE associated with targeted disruption and disease

4) Confidence 0.32 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.74 Pain Relevance 0

The data from these studies support the idea that there are isoform and tissue-specific roles for GSK-3 in the regulation of glucose metabolism and insulin action, such that GSK-3?

Regulation (regulation) of Gene_expression (action) of insulin

5) Confidence 0.17 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.79 Pain Relevance 0.08

Unfortunately the ITT did not show any significant differences in insulin sensitivity between the groups, probably due to a combination of groups of too few animals in which insulin resistance varies substantially, and a varied response to the experimental dose of insulin. 11?

Neg (not) Spec (probably) Regulation (differences) of Gene_expression (sensitivity) of insulin associated with insulin resistance

6) Confidence 0.05 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.44 Pain Relevance 0

General Comments

This test has worked.