INT191971

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Context Info
Confidence 0.45
First Reported 2006
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 1.97
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
blood 2
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 32 84.36 Quite High
Parenteral administration 3 67.12 Quite High
vagus nerve 3 59.20 Quite High
cINOD 5 5.00 Very Low Very Low Very Low
nMDA receptor 3 5.00 Very Low Very Low Very Low
peripheral neuropathy 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Nerve growth factor 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 58 99.78 Very High Very High Very High
Disease 134 99.56 Very High Very High Very High
Insulin Resistance 7 96.44 Very High Very High Very High
Diabetes Mellitus 88 91.52 High High
Impaired Glucose Tolerance 23 84.36 Quite High
Amyloid Plaque 9 79.56 Quite High
Hyperinsulinism 4 79.24 Quite High
Apoptosis 1 63.44 Quite High
Obesity 38 61.16 Quite High
Sprains And Strains 34 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed that serum insulin levels were not altered with the lowest dose of insulin (2 ?
Neg (not) Regulation (altered) of Gene_expression (levels) of insulin
1) Confidence 0.45 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
We observed that serum insulin levels were not altered with the lowest dose of insulin (2 ?
Neg (not) Regulation (altered) of Gene_expression (dose) of insulin
2) Confidence 0.38 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
In our experiment, blood glucose levels were not affected with lower doses of insulin (2 ?
Neg (not) Regulation (affected) of Gene_expression (doses) of insulin in blood
3) Confidence 0.38 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.06
A study using AD transgenic mice that had an over expression of IDE or NEP demonstrated a significant reduction in A?
Regulation (had) of Gene_expression (expression) of IDE associated with targeted disruption and disease
4) Confidence 0.32 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.74 Pain Relevance 0
The data from these studies support the idea that there are isoform and tissue-specific roles for GSK-3 in the regulation of glucose metabolism and insulin action, such that GSK-3?
Regulation (regulation) of Gene_expression (action) of insulin
5) Confidence 0.17 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.79 Pain Relevance 0.08
Unfortunately the ITT did not show any significant differences in insulin sensitivity between the groups, probably due to a combination of groups of too few animals in which insulin resistance varies substantially, and a varied response to the experimental dose of insulin. 11?
Neg (not) Spec (probably) Regulation (differences) of Gene_expression (sensitivity) of insulin associated with insulin resistance
6) Confidence 0.05 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.44 Pain Relevance 0

General Comments

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