INT191974

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Context Info
Confidence 0.38
First Reported 2005
Last Reported 2011
Negated 2
Speculated 8
Reported most in Body
Documents 16
Total Number 24
Disease Relevance 9.54
Pain Relevance 2.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
brain 4
blood 2
liver 2
muscle 2
plasma 1
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 170 100.00 Very High Very High Very High
agonist 81 99.30 Very High Very High Very High
alcohol 12 99.20 Very High Very High Very High
Central nervous system 13 98.68 Very High Very High Very High
Parenteral administration 5 95.84 Very High Very High Very High
cINOD 50 94.24 High High
vagus nerve 29 93.44 High High
withdrawal 3 92.40 High High
Prostatitis 1 86.20 High High
anesthesia 7 85.16 High High
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 142 100.00 Very High Very High Very High
Diabetes Mellitus 260 99.44 Very High Very High Very High
Alzheimer's Dementia 79 99.16 Very High Very High Very High
Hypothermia 3 98.94 Very High Very High Very High
Sprains And Strains 203 98.90 Very High Very High Very High
Disease 114 98.56 Very High Very High Very High
Targeted Disruption 314 97.00 Very High Very High Very High
Hyperinsulinism 26 96.60 Very High Very High Very High
Atherosclerotic Plaque 2 95.20 Very High Very High Very High
Body Weight 68 91.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is also a clinical evidence indicating that intensive insulin treatment in Type 2 diabetes improve ?
Regulation (intensive) of insulin associated with diabetes mellitus
1) Confidence 0.38 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.10 Pain Relevance 0
In this study, we examined the activity of IDE and NEP on formation of relevant ?
Spec (examined) Regulation (activity) of IDE
2) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.26 Pain Relevance 0.05
We have examined the ability of IDE and NEP to generate amyloid-forming species from the exposed and non-amyloidogenic hAChE T40 oligomerisation domain and the consequences for heterologous seeding of A?
Spec (examined) Regulation (ability) of IDE associated with alzheimer's dementia
3) Confidence 0.26 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.54 Pain Relevance 0
To rule out the influence of endogenous insulin on SIT, we felt it is necessary to measure the serum insulin levels.
Regulation (influence) of insulin
4) Confidence 0.23 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
Therefore, to study the effect of insulin and associated fall in blood glucose levels on intestinal transit, the charcoal meal was administered 30 min after insulin administration.
Regulation (effect) of insulin in blood
5) Confidence 0.23 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.05
We observed that serum insulin levels were not altered with the lowest dose of insulin (2 ?
Neg (not) Regulation (altered) of insulin
6) Confidence 0.20 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
While insulin in all the doses tested produced similar degree of acceleration of SIT, the effect on serum insulin levels was noticed to be dose related.


Regulation (effect) of insulin
7) Confidence 0.20 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.04
, to examine the relative contribution of two insulin-sensitive tissues, muscle and liver, towards the insulin sensitization phenotype originally observed in the global GSK-3?
Spec (examine) Regulation (contribution) of insulin in liver
8) Confidence 0.17 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017066 Disease Relevance 0.70 Pain Relevance 0.04
, to examine the relative contribution of two insulin-sensitive tissues, muscle and liver, towards the insulin sensitization phenotype originally observed in the global GSK-3?
Spec (examine) Regulation (contribution) of insulin-sensitive in liver
9) Confidence 0.17 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017066 Disease Relevance 0.69 Pain Relevance 0.04
Given the strain differences in our original analyses, we examined the insulin and glucose sensitivity of global GSK-3?
Spec (examined) Regulation (sensitivity) of insulin associated with sprains and strains
10) Confidence 0.17 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017066 Disease Relevance 0.69 Pain Relevance 0.05
has minimal effects on glucose tolerance and insulin sensitivity.
Regulation (effects) of insulin associated with tolerance and impaired glucose tolerance
11) Confidence 0.17 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.34 Pain Relevance 0.14
Insulin sensitivity was determined in mice fasted for 4 h by i.p. injection of insulin (Humulin, 0.75 mg/kg; Eli Lilly, France) and measurement of plasma glucose at 15, 30, 60 and 90 min.
Regulation (sensitivity) of Insulin in plasma
12) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.32 Pain Relevance 0.05
In addition, no significant difference in insulin sensitivity was observed.
Regulation (sensitivity) of insulin
13) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.23 Pain Relevance 0.09
Figure 3Glucose tolerance and insulin sensitivity of wt and P2Y1-/- mice.
Regulation (sensitivity) of insulin associated with tolerance
14) Confidence 0.16 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.27 Pain Relevance 0.17
Taken together, decreased phosphatase activity, hypothermia, as well as additional metabolic alterations due to insulin deficiency and high brain glucose levels may contribute concomitantly to the increased phosphorylation of tau in STZ-injected non-transgenic mice.
Regulation (deficiency) of insulin in brain associated with targeted disruption and hypothermia
15) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2775636 Disease Relevance 0.58 Pain Relevance 0.16
, to examine the relative contribution of two insulin-sensitive tissues, muscle and liver, towards the insulin sensitization phenotype originally observed in the global GSK-3?
Spec (examine) Regulation (contribution) of insulin in muscle
16) Confidence 0.06 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017066 Disease Relevance 0.70 Pain Relevance 0.04
, to examine the relative contribution of two insulin-sensitive tissues, muscle and liver, towards the insulin sensitization phenotype originally observed in the global GSK-3?
Spec (examine) Regulation (contribution) of insulin-sensitive in muscle
17) Confidence 0.06 Published 2011 Journal PLoS ONE Section Abstract Doc Link PMC3017066 Disease Relevance 0.69 Pain Relevance 0.04
However, despite favourable effects on the insulin-sensitising adipokine adiponectin in genetic models of 11?
Regulation (effects) of insulin-sensitising
18) Confidence 0.05 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 1.25 Pain Relevance 0.15
This study was designed to examine the impact of cardiac-specific overexpression of alcohol dehydrogenase (ADH) on ethanol-induced change in cardiac contractile function, intracellular Ca2+ homeostasis, insulin and AMP-dependent kinase (AMPK) signaling.


Regulation (change) of insulin associated with alcohol
19) Confidence 0.05 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2890411 Disease Relevance 0.33 Pain Relevance 0.18
We previously reported that brain insulin signaling increases the arterial femoral blood flow by a mechanism that does not require the cholinergic tone, since the central insulin signal was not affected by atropine (4).
Neg (not) Regulation (affected) of insulin in brain
20) Confidence 0.04 Published 2008 Journal Diabetes Section Body Doc Link PMC2551665 Disease Relevance 0.22 Pain Relevance 0.40

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