INT191978

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Context Info
Confidence 0.63
First Reported 2005
Last Reported 2011
Negated 2
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 6.80
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ide) mitochondrion (Ide) extracellular space (Ide)
ATPase activity (Ide) nucleus (Ide)
Anatomy Link Frequency
liver 3
muscle 3
skeletal muscle 2
brain 2
blood 2
Ide (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 122 100.00 Very High Very High Very High
alcohol 14 100.00 Very High Very High Very High
withdrawal 1 97.44 Very High Very High Very High
Hippocampus 29 88.72 High High
Inflammation 10 75.12 Quite High
metalloproteinase 40 69.56 Quite High
vagus nerve 6 55.40 Quite High
substance P 9 5.00 Very Low Very Low Very Low
depression 9 5.00 Very Low Very Low Very Low
Parenteral administration 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Impaired Glucose Tolerance 99 100.00 Very High Very High Very High
Insulin Resistance 28 100.00 Very High Very High Very High
Targeted Disruption 266 99.84 Very High Very High Very High
Disease 384 99.42 Very High Very High Very High
Alzheimer's Dementia 95 98.24 Very High Very High Very High
Sprains And Strains 168 94.44 High High
Diabetes Mellitus 211 92.96 High High
Hypoglycemia 13 86.16 High High
Body Weight 38 84.04 Quite High
Disorder Of Lipid Metabolism 6 83.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, the overexpression of IDE in transgenic mice results in drastically reduced brain A?
Positive_regulation (overexpression) of Gene_expression (overexpression) of IDE in brain associated with targeted disruption
1) Confidence 0.63 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989646 Disease Relevance 0.55 Pain Relevance 0.06
But with the higher doses of insulin (2 m and 2 U/kg), the serum insulin levels were significantly elevated (P < 0.01) (Fig 3).
Positive_regulation (elevated) of Gene_expression (levels) of insulin
2) Confidence 0.51 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
To further elucidate the role of endogenous insulin levels on SIT with higher doses of insulin, we evaluated C-peptide of insulin levels.
Positive_regulation (evaluated) of Gene_expression (levels) of insulin
3) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.09 Pain Relevance 0
But with the higher doses of insulin (2 m and 2 U/kg), the serum insulin levels were significantly elevated (P < 0.01) (Fig 3).
Positive_regulation (elevated) of Gene_expression (doses) of insulin
4) Confidence 0.42 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0 Pain Relevance 0.03
In this animal model, the above observation further confirms the view that higher doses of exogenously administered insulin reflexly stimulate the synthesis of insulin which resulted in release of C-peptide.
Positive_regulation (stimulate) of Gene_expression (synthesis) of insulin
5) Confidence 0.39 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.15 Pain Relevance 0
These findings indicate that exogenously administered insulin is solely responsible for significant acceleration of SIT, but with the higher doses of insulin elevated endogenous insulin levels produced cannot be ruled out in acceleration of SIT.
Positive_regulation (elevated) of Neg (cannot) Gene_expression (produced) of insulin
6) Confidence 0.39 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.07 Pain Relevance 0
A study using AD transgenic mice that had an over expression of IDE or NEP demonstrated a significant reduction in A?
Positive_regulation (over) of Gene_expression (expression) of IDE associated with targeted disruption and disease
7) Confidence 0.36 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.74 Pain Relevance 0
The elevated serum insulin levels observed with higher doses of insulin might be due to insulin administration itself or a reflex release of endogenous insulin from the pancreas.
Positive_regulation (elevated) of Gene_expression (levels) of insulin in pancreas
8) Confidence 0.34 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1444921 Disease Relevance 0.07 Pain Relevance 0
T40/IDE digestion promotes A?
Positive_regulation (promotes) of Gene_expression (digestion) of T40/IDE
9) Confidence 0.33 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.10 Pain Relevance 0
This result underlines the importance of the T40 CSR, which is included within the T40/IDE products and AChE586-599, and provides an insight into the identity of an AChE domain that may cooperate with A?
Positive_regulation (included) of Gene_expression (products) of T40/IDE
10) Confidence 0.29 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1920558 Disease Relevance 0.48 Pain Relevance 0
However, after injection of glucose (3 g/kg), no significant difference in insulin levels was observed between the two genotypes at 30 and 60 min (Table 2).
Neg (no) Positive_regulation (difference) of Gene_expression (levels) of insulin
11) Confidence 0.29 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096536 Disease Relevance 0.21 Pain Relevance 0.16
in skeletal muscle improves glucose tolerance and insulin signaling, while removal of this isoform in ?
Positive_regulation (improves) of Gene_expression (improves) of insulin in skeletal muscle associated with tolerance and impaired glucose tolerance
12) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.88 Pain Relevance 0.13
reported here, we postulate that enhanced neuronal insulin signaling may contribute to the improved metabolic and liver-specific phenotype observed in the global GSK-3?
Positive_regulation (enhanced) of Gene_expression (signaling) of insulin in liver
13) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.20 Pain Relevance 0.03
KO provoked enhanced insulin sensitivity and hepatic glucose metabolism, tissue-specific deletions of GSK-3?
Positive_regulation (enhanced) of Gene_expression (sensitivity) of insulin associated with targeted disruption
14) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.57 Pain Relevance 0
In addition, the extent of insulin- and glucose-induced dephosphorylation and activation of GS in muscle and liver tissues was comparable in Alb Cre + and Alb Cre – mice (Figures 6A and 6B) and the amount of glycogen deposited within in these tissues was also unaffected by the loss of hepatic GSK-3?
Positive_regulation (activation) of Gene_expression (extent) of insulin in muscle
15) Confidence 0.19 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.31 Pain Relevance 0
As shown in Table 2, the levels of serum insulin were elevated after administration of 4.0 g/kg body wt CSE (9.8 ± 0.5 ?
Positive_regulation (elevated) of Gene_expression (levels) of insulin in body
16) Confidence 0.18 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2785813 Disease Relevance 0.64 Pain Relevance 0
Further, insulin resistance induced by 5 months of high-fat diet, in 9-month-old Tg2576 mice, was associated with to a twofold increase of A?
Positive_regulation (induced) of Gene_expression (resistance) of insulin in fat associated with insulin resistance
17) Confidence 0.12 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2952897 Disease Relevance 0.80 Pain Relevance 0.11
Plasma insulin levels and blood alcohol levels were significantly elevated in a comparable manner in both groups following acute ethanol challenge (Table 1).
Positive_regulation (elevated) of Gene_expression (levels) of insulin in blood associated with alcohol
18) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2890411 Disease Relevance 0.08 Pain Relevance 0.09
In addition, the extent of insulin- and glucose-induced dephosphorylation and activation of GS in muscle and liver tissues was comparable in Alb Cre + and Alb Cre – mice (Figures 6A and 6B) and the amount of glycogen deposited within in these tissues was also unaffected by the loss of hepatic GSK-3?
Positive_regulation (activation) of in liver Gene_expression (extent) of insulin in muscle
19) Confidence 0.07 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017066 Disease Relevance 0.31 Pain Relevance 0
Unfortunately the ITT did not show any significant differences in insulin sensitivity between the groups, probably due to a combination of groups of too few animals in which insulin resistance varies substantially, and a varied response to the experimental dose of insulin. 11?
Positive_regulation (response) of Gene_expression (dose) of insulin associated with insulin resistance
20) Confidence 0.06 Published 2008 Journal BMC Pharmacol Section Body Doc Link PMC2270815 Disease Relevance 0.56 Pain Relevance 0

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