INT19199

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.37
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 17
Disease Relevance 10.07
Pain Relevance 21.73

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
RVM 9
neurons 2
dorsal horn 2
spinal 1
peripheral nerve 1
Rvm (Mus musculus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 226 100.00 Very High Very High Very High
medulla 19 100.00 Very High Very High Very High
Rostroventromedial medulla 17 100.00 Very High Very High Very High
antagonist 16 100.00 Very High Very High Very High
lidocaine 11 99.98 Very High Very High Very High
Serotonin 7 99.84 Very High Very High Very High
Morphine 20 99.74 Very High Very High Very High
ascending facilitation 11 99.62 Very High Very High Very High
Hyperalgesia 34 99.48 Very High Very High Very High
spinal dorsal horn 7 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 24 99.56 Very High Very High Very High
Hyperalgesia 39 99.48 Very High Very High Very High
Hypersensitivity 21 98.62 Very High Very High Very High
Hypothermia 3 98.52 Very High Very High Very High
Diabetes Mellitus 7 97.64 Very High Very High Very High
Nociception 43 97.36 Very High Very High Very High
Injury 28 95.96 Very High Very High Very High
Neuropathic Pain 68 95.20 Very High Very High Very High
Peripheral Neuropathy 1 95.12 Very High Very High Very High
Pain 99 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
That inactivation of RVM reduces the hyperalgesia indicates that the CNS is capable of generating a facilitating action on nociceptive transmission.
Negative_regulation (inactivation) of RVM in RVM associated with nociception, hyperalgesia and rostral ventromedial medulla
1) Confidence 0.37 Published 1991 Journal J. Neurosci. Section Abstract Doc Link 2027054 Disease Relevance 0.60 Pain Relevance 1.53
In contrast, lidocaine inactivation of the RVM completely reversed the hindpaw reflex facilitation produced by tail heat, indicating the involvement of RVM ON-cells in facilitation of this reflex. 4.
Negative_regulation (inactivation) of RVM associated with lidocaine and rostral ventromedial medulla
2) Confidence 0.37 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7807201 Disease Relevance 0.27 Pain Relevance 0.81
Lidocaine inactivation of the RVM shortened the latency for both reflexes but had no effect on tail flick inhibition produced by the noxious conditioning stimulus.
Negative_regulation (inactivation) of RVM in RVM associated with tail-flick, lidocaine and rostral ventromedial medulla
3) Confidence 0.37 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7807201 Disease Relevance 0.35 Pain Relevance 0.75
By pharmacologically blocking RVM activity with the local anesthetic lignocaine, and then measuring evoked responses of dorsal horn neurons to a range of applied peripheral stimuli, our aim was to determine the prevailing descending influence operating in normal anesthetized animals and animals with experimental neuropathic pain.
Negative_regulation (blocking) of RVM in dorsal horn associated with neuropathic pain, dorsal horn neuron, local anesthetic and rostral ventromedial medulla
4) Confidence 0.37 Published 2007 Journal Neuroscience Section Abstract Doc Link 17570596 Disease Relevance 0.09 Pain Relevance 0.62
These findings demonstrate activity-dependent plasticity in brain stem circuits that includes changes in excitatory amino acid receptor activation and sensitivity and a phenotypic switch of some RVM neurons.
Negative_regulation (switch) of RVM in neurons associated with excitatory amino acid
5) Confidence 0.37 Published 2004 Journal Suppl Clin Neurophysiol Section Abstract Doc Link 16106600 Disease Relevance 0.53 Pain Relevance 0.40
Lidocaine inactivation of the RVM did not block antinociception produced by Ficoll infusion.
Negative_regulation (inactivation) of RVM in RVM associated with antinociception, lidocaine and rostral ventromedial medulla
6) Confidence 0.28 Published 1993 Journal Pain Section Abstract Doc Link 8446430 Disease Relevance 0.24 Pain Relevance 1.01
Such hypersensitivity was reversed in a time-dependent manner by L365,260 in the RVM, and blockade of CCK2 receptors in the RVM also blocked the rightward displacement of the spinal morphine antinociceptive dose-response curve.
Negative_regulation (blockade) of RVM in RVM associated with hypersensitivity, antinociceptive, morphine and rostral ventromedial medulla
7) Confidence 0.23 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 15647484 Disease Relevance 0.75 Pain Relevance 2.48
Blocking afferent drive with bupivicaine also restored lost potency of PAG morphine, as did CCK antagonists in the RVM.
Negative_regulation (antagonists) of RVM in RVM associated with rostroventromedial medulla, antagonist, urological neuroanatomy, morphine and potency
8) Confidence 0.21 Published 2000 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 10911921 Disease Relevance 0.81 Pain Relevance 2.47
Spinal antinociception induced by electric stimulation of M1 was reduced following block of the RVM with intramedullary injection of muscimol, a GABA(A) receptor agonist, or following intrathecal administration of WAY-100635, a 5-HT(1A) receptor antagonist.
Negative_regulation (block) of RVM in RVM associated with antinociception, gaba, rostroventromedial medulla, antagonist, agonist and intrathecal
9) Confidence 0.17 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20398735 Disease Relevance 0.51 Pain Relevance 1.11
However, given the high basal levels of pERK reported here, it is unlikely that direct injections of ERK inhibitors into the RVM would resolve this issue.
Negative_regulation (inhibitors) of RVM associated with rostral ventromedial medulla
10) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.70 Pain Relevance 1.09
Finally, inactivation of the RVM with lidocaine or excitatory block with the glutamate receptor antagonist kynurenate lead to attenuation of mechanical allodynia caused by inflammation or peripheral nerve ligation respectively [12,13].
Negative_regulation (inactivation) of RVM in peripheral nerve associated with inflammation, allodynia, antagonist, glutamate receptor, lidocaine and rostral ventromedial medulla
11) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.74 Pain Relevance 1.04
This effect was mimicked by down-regulation of RVM sigma(1) receptors using an antisense approach.
Negative_regulation (down-regulation) of RVM in RVM associated with medulla
12) Confidence 0.15 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17545312 Disease Relevance 0.56 Pain Relevance 2.46
Compared to negative control shRNA, Tph-2 shRNA induced significantly prolonged downregulation of Tph-2 in the RVM and 5-HT in spinal dorsal horn.
Negative_regulation (downregulation) of RVM in dorsal horn associated with spinal dorsal horn and rostral ventromedial medulla
13) Confidence 0.10 Published 2010 Journal J. Neurosci. Section Abstract Doc Link 20573908 Disease Relevance 0.85 Pain Relevance 1.20
Inactivation of the RVM by muscimol microinjections completely attenuated antincociceptive responses produced by intraventricular improgan.
Negative_regulation (Inactivation) of RVM in RVM associated with rostral ventromedial medulla
14) Confidence 0.09 Published 2004 Journal Brain Res. Section Abstract Doc Link 15342273 Disease Relevance 0.59 Pain Relevance 1.25
Blocking descending facilitation, by lesion of the RVM or spinal blockade of serotonin receptors, is antinociceptive [67-69].
Negative_regulation (blockade) of RVM in spinal associated with rostroventromedial medulla, ascending facilitation, antinociceptive and serotonin
15) Confidence 0.08 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.76 Pain Relevance 0.84
The present study evaluated whether serotonergic (methysergide: 5-10 microg) or competitive [AP7 (2-amino-7-phosphonoheptanoic acid): 0.01-0.1 microg] or non-competitive [MK-801 (dizocilipine maleate): 0.3-3 microg] NMDA antagonists in the RVM altered CCWS and ICWS analgesia and hypothermia as well as basal nociceptive latencies.
Negative_regulation (antagonists) of RVM in RVM associated with nociception, hypothermia, antagonist, analgesia and rostral ventromedial medulla
16) Confidence 0.07 Published 1998 Journal Physiol. Behav. Section Abstract Doc Link 9748086 Disease Relevance 0.72 Pain Relevance 1.66
Conditioning electrical stimulation and a lidocaine block of the rostroventromedial medulla (RVM) had a similar modulatory effect on evoked responses of spinal dorsal horn WDR neurons in all experimental groups.
Negative_regulation (block) of RVM in neurons associated with rostroventromedial medulla, spinal dorsal horn and lidocaine
17) Confidence 0.07 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11161631 Disease Relevance 1.01 Pain Relevance 1.02

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox