INT1920

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Context Info
Confidence 0.40
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.29
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PLAT) protein modification process (PLAT) extracellular space (PLAT)
extracellular region (PLAT) cytoplasm (PLAT)
Anatomy Link Frequency
blood vessels 2
BC-1 2
PLAT (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 13 95.08 Very High Very High Very High
palliative 1 72.24 Quite High
iatrogenic 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
withdrawal 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Breast Disease 2 99.88 Very High Very High Very High
Cancer 53 99.44 Very High Very High Very High
Metastasis 25 92.48 High High
Advanced Or Metastatic Breast Cancer 3 92.04 High High
Breast Cancer 4 88.12 High High
Viral Infection 7 87.60 High High
Hypergammaglobulinemia 1 85.44 High High
Recurrence 1 83.36 Quite High
Disease 60 82.84 Quite High
Sarcoma 195 61.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CEA levels were not elevated in patients with benign breast disease, but levels of TPA were elevated in 27% of those studied.
Positive_regulation (elevated) of Positive_regulation (levels) of TPA associated with breast disease
1) Confidence 0.40 Published 1979 Journal J. Natl. Cancer Inst. Section Abstract Doc Link 292806 Disease Relevance 1.01 Pain Relevance 0.07
There are two types of plasminogen activators (PA), the urokinase-type (uPA) and the tissue-type (tPA). uPA is generally agreed to be the enzyme of most relevance to tumor biology, while the primary role of tPA is generation of plasmin for fibrinolysis in blood vessels.
Positive_regulation (generation) of Positive_regulation (role) of tPA in blood vessels associated with cancer
2) Confidence 0.21 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2956083 Disease Relevance 0.59 Pain Relevance 0
It is a Class II transcript in that it is constitutively expressed in the BCP-1 cell line, but its expression is greatly increased after induction with TPA; it is a Class III transcript in the BC-1 cell line [63].
Positive_regulation (increased) of Positive_regulation (induction) of TPA in BC-1
3) Confidence 0.12 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 0.69 Pain Relevance 0.15

General Comments

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