INT192055

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.57
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Pbx1) nucleus (Pbx1) DNA binding (Pbx1)
transcription factor binding (Pbx1) cytoplasm (Pbx1)
Anatomy Link Frequency
ducts 1
Pbx1 (Mus musculus)
Pain Link Frequency Relevance Heat
sodium channel 1 37.44 Quite Low
Bile 16 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
endometriosis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
agonist 1 5.00 Very Low Very Low Very Low
Eae 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 24 92.44 High High
Leukemia 5 89.48 High High
B-cell Acute Lymphoblastic Leukemia 1 88.84 High High
Myeloid Leukemia 1 79.40 Quite High
Disease 6 79.16 Quite High
Acute Myeloid Leukemia 4 71.96 Quite High
Aplasia 4 68.88 Quite High
Cancer 8 43.28 Quite Low
Hyperplasia 1 37.20 Quite Low
Obesity 17 36.48 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, PBX1 is expressed in the Müllerian ducts at the onset of genital tract differentiation whereas it is absent of Wolffian ducts (the primordia for male inner genital tract) during the same period and in both sexes [30].
Neg (absent) Gene_expression (expressed) of PBX1 in ducts
1) Confidence 0.65 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1444933 Disease Relevance 0.16 Pain Relevance 0
CDKN1A reporter expression is enhanced after transfection with PBX1 and HOXA10, especially when MEIS1 was co-transfected (Bromleigh and Freedman, 2000).
Gene_expression (transfection) of PBX1
2) Confidence 0.39 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.24 Pain Relevance 0
Fgf15 was originally identified as a downstream target of the chimeric homoedomain oncoprotein E2A-Pbx1 in mice (McWhirter et al. 1997).
Gene_expression (target) of E2A-Pbx1
3) Confidence 0.35 Published 2010 Journal Cell Tissue Res Section Body Doc Link PMC2948652 Disease Relevance 0.17 Pain Relevance 0

General Comments

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