INT192058

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Context Info
Confidence 0.65
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 1.11
Pain Relevance 0.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hoxa10) DNA binding (Hoxa10)
Anatomy Link Frequency
uterine 2
embryo 1
adult uterus 1
patterning 1
Hoxa10 (Mus musculus)
Pain Link Frequency Relevance Heat
endometriosis 8 95.92 Very High Very High Very High
cva 8 66.64 Quite High
anesthesia 10 5.00 Very Low Very Low Very Low
imagery 7 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
abdominal pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Leukemia 40 99.40 Very High Very High Very High
Endometriosis (extended) 8 95.92 Very High Very High Very High
Ovarian Cancer 8 95.32 Very High Very High Very High
Myeloid Leukemia 8 92.64 High High
Reprotox - General 3 8 92.36 High High
Acute Myeloid Leukemia 32 85.20 High High
Hemorrhage 8 66.64 Quite High
Anaemia 8 64.00 Quite High
Targeted Disruption 21 60.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 8 55.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to examining this RNA sample for the presence of Hoxc11-specific transcripts, we determined whether there was evidence for expression of the remaining AbdB-type Hoxc genes (Hoxc9, Hoxc10, Hoxc12, and Hoxc13), as well as for the Hoxc11 and Hoxc10 paralogous genes (Hoxa11, Hoxd11, and Hoxa10, Hoxd10).
Gene_expression (expression) of Hoxa10
1) Confidence 0.65 Published 2008 Journal BMC Dev Biol Section Body Doc Link PMC2570687 Disease Relevance 0.06 Pain Relevance 0
Finally HOXA10 to HOXA13 are also expressed in the developing kidney [21] and are both required for correct patterning of the skeleton [22].
Gene_expression (expressed) of HOXA10 in patterning
2) Confidence 0.57 Published 2006 Journal J Negat Results Biomed Section Body Doc Link PMC1444933 Disease Relevance 0 Pain Relevance 0
CDKN1A reporter expression is enhanced after transfection with PBX1 and HOXA10, especially when MEIS1 was co-transfected (Bromleigh and Freedman, 2000).
Gene_expression (transfection) of HOXA10
3) Confidence 0.54 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.24 Pain Relevance 0
MEIS1 mRNA levels appeared significantly increased in the mid secretory phase, closely resembling the expression pattern of HOXA10.
Gene_expression (expression) of HOXA10
4) Confidence 0.54 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.19 Pain Relevance 0.03
Hoxa10 expression persists in the adult uterus and is important for implantation of the embryo.
Gene_expression (expression) of Hoxa10 in adult uterus
5) Confidence 0.54 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
In addition, Pineault et al. (2004) demonstrated that MEIS1 enhances the effect of a HOXA10 rearrangement releasing HOX expression necessary for leukemia induction.
Gene_expression (expression) of HOXA10 associated with leukemia
6) Confidence 0.47 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.28 Pain Relevance 0
Together, these results showed that, in a murine uterine receptivity model, the expression of the known Hoxa10 target Itgb3 could be regulated by the manipulation of Meis1 expression, suggesting Meis1 action through co-operation, or possibly interaction, with Hoxa10.


Gene_expression (expression) of Hoxa10 in uterine
7) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0
Defective endometrial HOXA10 expression has been described in several conditions that result in diminished human embryo implantation such as endometriosis, polycystic ovarian syndrome, and hydrosalpinx fluid (Taylor et al., 1999; Daftary and Taylor 2002; Cermik et al., 2003).
Gene_expression (expression) of HOXA10 in embryo associated with endometriosis and ovarian cancer
8) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.26 Pain Relevance 0.05
In humans, HOXA10 expression is up-regulated in the mid-luteal phase at the time of implantation, and its expression is driven by estrogen and progesterone (Taylor et al., 1998).
Gene_expression (expression) of HOXA10
9) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0.09 Pain Relevance 0
In the developing mouse embryo, altered Hoxa10 expression as a result of targeted mutation (Satokata et al., 1995) or exposure to diethylstilbestrol leads to abnormal uterine development (Block et al., 2000).
Gene_expression (expression) of Hoxa10 in uterine
10) Confidence 0.42 Published 2008 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2387222 Disease Relevance 0 Pain Relevance 0

General Comments

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