INT192080

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Context Info
Confidence 0.14
First Reported 2006
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.72
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
nucleus (Foxm1) embryo development (Foxm1) DNA binding (Foxm1)
Anatomy Link Frequency
brain 1
Foxm1 (Mus musculus)
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 63 100.00 Very High Very High Very High
Cannabinoid receptor 31 100.00 Very High Very High Very High
agonist 28 100.00 Very High Very High Very High
antagonist 24 98.92 Very High Very High Very High
qutenza 28 87.92 High High
Nucleus accumbens 2 70.00 Quite High
Central grey 1 60.00 Quite High
Dopamine 24 57.48 Quite High
substance P 9 30.48 Quite Low
dopamine receptor 1 25.40 Quite Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 3 98.48 Very High Very High Very High
Targeted Disruption 3 97.48 Very High Very High Very High
Cough 64 88.52 High High
Urological Neuroanatomy 1 60.00 Quite High
Stress 2 41.20 Quite Low
Recurrence 3 5.00 Very Low Very Low Very Low
Sprains And Strains 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Psychosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In a similar way to WIN, SR 141716 is reported to exhibit an independent CB1 activity; for instance, it exerts an anxiolytic effect on CB1 knockout mice [30] The aversive effects of cannabinoid agonists observed in many studies, and the rewarding effect of cannabinoid antagonists are suggestive of a cannabinergic tone in the rat brain.
WIN Neg (independent) Positive_regulation (exhibit) of CB1 in brain associated with targeted disruption, antagonist, cannabinoid, anxiety disorder and agonist
1) Confidence 0.14 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2858089 Disease Relevance 0.31 Pain Relevance 0.69
We previously demonstrated that WIN 55212-2, a cannabinoid receptor agonist, had an antitussive effect through the activation of cannabinoid CB1 receptors [3].
WIN Positive_regulation (activation) of CB1 associated with cannabinoid receptor, cannabinoid and agonist
2) Confidence 0.06 Published 2006 Journal Cough Section Body Doc Link PMC1448189 Disease Relevance 0.41 Pain Relevance 0.61

General Comments

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