INT192092

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Context Info
Confidence 0.32
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 4.41
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Rara) nucleus (Rara) enzyme binding (Rara)
DNA binding (Rara) transcription factor binding (Rara) cytoplasm (Rara)
Anatomy Link Frequency
immune cells 2
spinal cord 2
peripheral nervous system 2
Rara (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 128 99.38 Very High Very High Very High
Peripheral nervous system 24 99.16 Very High Very High Very High
Central nervous system 69 97.40 Very High Very High Very High
Arthritis 10 95.72 Very High Very High Very High
agonist 35 95.60 Very High Very High Very High
Multiple sclerosis 1 94.56 High High
cytokine 58 85.36 High High
alcohol 4 60.80 Quite High
antagonist 13 60.16 Quite High
dexamethasone 244 58.00 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 16 99.76 Very High Very High Very High
Injury 81 99.68 Very High Very High Very High
Asthma 9 96.32 Very High Very High Very High
Arthritis 10 95.72 Very High Very High Very High
Diabetes Mellitus 25 95.12 Very High Very High Very High
Multiple Sclerosis 3 94.56 High High
Rheumatoid Arthritis 490 92.52 High High
Frailty 80 86.92 High High
Aging 57 84.60 Quite High
Disease 38 81.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Manipulation of RAR/RXR signaling in the peripheral nervous system
Positive_regulation (Manipulation) of Gene_expression (/) of RAR in peripheral nervous system associated with peripheral nervous system
1) Confidence 0.32 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.46 Pain Relevance 0.32
They observed that the RAR?
Positive_regulation (observed) of Gene_expression (observed) of RAR
2) Confidence 0.32 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.39 Pain Relevance 0.36
About 500 genes have been suggested to be regulated by RAR/RXR
Positive_regulation (by) of Gene_expression (/) of RAR
3) Confidence 0.32 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.75 Pain Relevance 0.15
axonal regeneration into the spinal cord in vivo, Wong and others [99] transfected RAR?
Positive_regulation (transfected) of Gene_expression (transfected) of RAR in spinal cord associated with spinal cord
4) Confidence 0.28 Published 2007 Journal PPAR Research Section Body Doc Link PMC1950239 Disease Relevance 0.19 Pain Relevance 0.42
Our microarray data showed reduced expression with age for genes encoding proteins in complex I, III, and V of the oxidative phosphorylation pathway, whereas expression of genes in RAR activation pathway (such as Rdh9) mostly increased.
Positive_regulation (increased) of Gene_expression (expression) of RAR
5) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2975639 Disease Relevance 0.20 Pain Relevance 0
Similarly, action of vitamin A, so called retinol, is mediated over antigen presenting cells (APC) through specific intracellular retinoid acid receptors (RAR) [10] and retinoid × receptors (RXR)[11], which are present in the immune cells [12].
Positive_regulation (mediated) of Gene_expression (presenting) of RAR in immune cells
6) Confidence 0.24 Published 2009 Journal Nutr Metab (Lond) Section Body Doc Link PMC2773769 Disease Relevance 0.91 Pain Relevance 0.20
Meanwhile, the expression of RAR-?
Positive_regulation (Meanwhile) of Gene_expression (expression) of RAR
7) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.74 Pain Relevance 0.10
However, RAR-?
Positive_regulation (However) of Gene_expression (However) of RAR
8) Confidence 0.04 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.77 Pain Relevance 0.13

General Comments

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