INT192094

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.38
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Rxrg)
Anatomy Link Frequency
lung 2
Rxrg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 97 96.40 Very High Very High Very High
Central nervous system 2 76.24 Quite High
dexamethasone 244 71.88 Quite High
alcohol 2 56.96 Quite High
corticosteroid 16 45.12 Quite Low
fibrosis 4 19.96 Low Low
Inflammation 110 5.00 Very Low Very Low Very Low
ischemia 75 5.00 Very Low Very Low Very Low
cytokine 26 5.00 Very Low Very Low Very Low
tolerance 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 305 100.00 Very High Very High Very High
Cancer 47 100.00 Very High Very High Very High
Apoptosis 33 98.74 Very High Very High Very High
Stroke 75 84.88 Quite High
Uterine Fibroids 144 83.44 Quite High
Emphysema 6 79.00 Quite High
Starvation 4 63.80 Quite High
Targeted Disruption 7 63.20 Quite High
Diabetes Mellitus 33 60.40 Quite High
Obesity 8 59.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, the regulation of free all-trans-RA by RA-binding proteins and interactions with RA receptors (RAR and RXR) contribute to appropriate lung development.
RXR Binding (binding) of in lung associated with rheumatoid arthritis
1) Confidence 0.05 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.82 Pain Relevance 0.13
In addition, the regulation of free all-trans-RA by RA-binding proteins and interactions with RA receptors (RAR and RXR) contribute to appropriate lung development.
RXR Binding (interactions) of in lung associated with rheumatoid arthritis
2) Confidence 0.05 Published 2006 Journal Respir Res Section Body Doc Link PMC1448204 Disease Relevance 0.82 Pain Relevance 0.10
When their respective ligands bind to PPAR and RXR,
RXR Binding (bind) of
3) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 0.08 Pain Relevance 0.08
 :RXR complex can recruit corepressor complexes
RXR Binding (complex) of
4) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 0.18 Pain Relevance 0.08
Both RXR and PPAR are composed of a ligand
RXR Binding (Both) of
5) Confidence 0.04 Published 2008 Journal PPAR Research Section Body Doc Link PMC2293414 Disease Relevance 0.08 Pain Relevance 0.07
RA acts on tumor growth by binding and regulating the tumor cell heterodimeric receptors RAR and RXR.
RXR Binding (binding) of associated with cancer and rheumatoid arthritis
6) Confidence 0.02 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.32 Pain Relevance 0.03
It was demonstrated that its nuclear export and initiation of NR4A1-dependent apoptosis depends on the nuclear exporting signal (NES) residing on its binding partner RXR and is suppressed by RA [36].
RXR Binding (binding) of associated with rheumatoid arthritis and apoptosis
7) Confidence 0.02 Published 2007 Journal BMC Womens Health Section Body Doc Link PMC1852551 Disease Relevance 1.08 Pain Relevance 0.04

General Comments

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