INT19211

Context Info Confidence 0.48 First Reported 1984 Last Reported 2010 Negated 3 Speculated 0 Reported most in Body Documents 35 Total Number 35 Disease Relevance 16.29 Pain Relevance 3.31

extracellular space (Shbg) extracellular region (Shbg)

Anatomy Link Frequency blood 4 follicle 2 patella 2 hair 1 float 1 Shbg (Rattus norvegicus)

Pain Link Frequency Relevance Heat abdominal pain 9 99.80 Pain 19 99.76 Dismenorea 7 98.76 Cluster headache 6 98.24 Bioavailability 14 96.44 Snapping jaw 7 96.36 Angina 15 89.68 analgesia 1 89.16 Morphine 8 88.76 narcan 1 83.28

Disease Link Frequency Relevance Heat Peritonitis 320 100.00 Disorder Of Lipid Metabolism 137 99.92 Abdominal Pain 9 99.80 Pain 19 99.76 Rheumatoid Arthritis 12 99.32 Nicotine Addiction 25 99.20 Cardiovascular Disease 77 99.04 Infection 82 98.84 Reprotox - General 1 53 98.76 Fever 8 98.44

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The newer progestogens, like norethisterone and levonorgestrel, are bound to sex hormone binding globulin (SHBG).

sex hormone binding globulin Binding (bound) of

1) Confidence 0.48 Published 1991 Journal Clin Pharmacokinet Section Abstract Doc Link 2029800 Disease Relevance 0 Pain Relevance 0.08

The binding capacity and affinity of SHBG do not increase in direct proportion to its concentration.

SHBG Binding (affinity) of

2) Confidence 0.48 Published 1991 Journal Clin Pharmacokinet Section Abstract Doc Link 2029800 Disease Relevance 0 Pain Relevance 0.24

The newer progestogens, like norethisterone and levonorgestrel, are bound to sex hormone binding globulin (SHBG).

SHBG Binding (bound) of

3) Confidence 0.48 Published 1991 Journal Clin Pharmacokinet Section Abstract Doc Link 2029800 Disease Relevance 0 Pain Relevance 0.08

The observed positive association between SHBG and patella bone volume may reflect a favorable effect of estrogen exposure on patella bone volume.

SHBG Binding (association) of in patella

4) Confidence 0.46 Published 2007 Journal Semin. Arthritis Rheum. Section Body Doc Link 17303218 Disease Relevance 0.07 Pain Relevance 0

The most frequent symptoms associated with SBP are abdominal pain and/or tenderness, fever or new development of encephalopathy.

SBP Binding (associated) of associated with abdominal pain, encephalopathy, peritonitis and fever

5) Confidence 0.39 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 2.00 Pain Relevance 0.18

These results were consistent with the hypothesis that sex hormone status interacts with pain control systems to modify neural activity at the level of the Vc/C(2) junction region relevant for TMD pain.

sex hormone Binding (interacts) of in neural associated with pain

6) Confidence 0.39 Published 2005 Journal Pain Section Abstract Doc Link 15733646 Disease Relevance 0.76 Pain Relevance 1.41

The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome.

sex hormone binding globulin Binding (binding) of associated with dismenorea

7) Confidence 0.37 Published 1984 Journal J. Steroid Biochem. Section Title Doc Link 6538615 Disease Relevance 0.20 Pain Relevance 0.20

The blood test included serum testosterone, free testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone and luteinizing hormone.

sex hormone Binding (binding) of in follicle

8) Confidence 0.35 Published 2008 Journal Digestion Section Body Doc Link 18974649 Disease Relevance 0 Pain Relevance 0

The blood test included serum testosterone, free testosterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone and luteinizing hormone.

SHBG Binding (binding) of in follicle

9) Confidence 0.35 Published 2008 Journal Digestion Section Body Doc Link 18974649 Disease Relevance 0 Pain Relevance 0

SHBG showed a statistically positive association with patella bone volume after adjusting for confounders (P = 0.02).

SHBG Binding (association) of in patella

10) Confidence 0.35 Published 2007 Journal Semin. Arthritis Rheum. Section Body Doc Link 17303218 Disease Relevance 0.08 Pain Relevance 0

Chang and colleagues (1998) demonstrated that the prevalence of bacterial overgrowth was higher in patients with a history of SBP associated to disturbances in small intestinal motility.

SBP Binding (associated) of associated with peritonitis

11) Confidence 0.33 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 1.06 Pain Relevance 0

Three-way interactions emerged for SBP and DBP: Only for those in expressive suppression condition, anger-out was related significantly to SBP during and following cold pressor and to DBP following cold pressor.

SBP Binding (interactions) of

12) Confidence 0.31 Published 2007 Journal Ann Behav Med Section Body Doc Link 17927554 Disease Relevance 0 Pain Relevance 0

Mercury remained positively associated with SBP (beta = 4.77; p = 0.01) and PP (beta = 3.40; p = 0.0036) after adjusting for confounders.

SBP Binding (associated) of

13) Confidence 0.30 Published 2008 Journal Environ Health Section Body Doc Link PMC2443124 Disease Relevance 0 Pain Relevance 0

Furthermore, our results are in accordance with results derived from hair's mercury measurement showing an association with increased SBP [20].

SBP Binding (association) of in hair

14) Confidence 0.30 Published 2008 Journal Environ Health Section Body Doc Link PMC2443124 Disease Relevance 0.34 Pain Relevance 0.03

The ascitic total protein has been recognized as predictive of SBP development and the risk is higher when values of less than 1 g/dL of total protein are found (Runyon 1986; Llach et al 1992) and some experts recommend primary prophylaxis (Frazee et al 2005).

SBP Binding (recognized) of associated with peritonitis

15) Confidence 0.29 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 1.09 Pain Relevance 0

Some authors have pointed the existence of several risk factors associated with SBP.

SBP Binding (associated) of associated with peritonitis

16) Confidence 0.29 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621420 Disease Relevance 1.24 Pain Relevance 0

For the most part, steroid hormones in the bloodstream do not float around freely, but are bound to carrier proteins, such as SHBG and albumin.

SHBG Binding (bound) of in float

17) Confidence 0.28 Published 2006 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1524969 Disease Relevance 0 Pain Relevance 0.08

Total testosterone concentrations and sex hormone-binding globulin (SHBG) were significantly associated with LDL size in men (Haffner et al., 1996).

SHBG Binding (associated) of

18) Confidence 0.23 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788163 Disease Relevance 1.03 Pain Relevance 0

Total testosterone concentrations and sex hormone-binding globulin (SHBG) were significantly associated with LDL size in men (Haffner et al., 1996).

hormone-binding globulin Binding (associated) of

19) Confidence 0.20 Published 2009 Journal Nutrition Research and Practice Section Body Doc Link PMC2788163 Disease Relevance 1.04 Pain Relevance 0

DRSP is highly bound to serum metabolites (approximately 97%) but does not bind to sex hormone binding globulin (SHBG).

SHBG Neg (not) Binding (bind) of

20) Confidence 0.19 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778416 Disease Relevance 0.07 Pain Relevance 0.09

General Comments

This test has worked.