INT19215

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Context Info
Confidence 0.65
First Reported 1991
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 1.63
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Cpm) plasma membrane (Cpm) nucleus (Cpm)
cytoplasm (Cpm)
Anatomy Link Frequency
MAC 2
spicules 1
knee 1
Cpm (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain management 8 100.00 Very High Very High Very High
Action potential 152 93.96 High High
dorsal root ganglion 204 93.36 High High
Enkephalin 2 85.08 High High
bradykinin 2 83.80 Quite High
palliative 19 83.04 Quite High
Pain 25 77.92 Quite High
cytokine 2 70.32 Quite High
Kinase C 8 60.76 Quite High
Osteoarthritis 27 32.00 Quite Low
Disease Link Frequency Relevance Heat
Cancer 41 99.70 Very High Very High Very High
Hypersensitivity Pneumonitis 2 96.20 Very High Very High Very High
Graft Vs Host Disease 2 95.28 Very High Very High Very High
Ganglion Cysts 204 93.36 High High
Pain 21 77.92 Quite High
Cancer Pain 2 75.00 Quite High
Bordatella Infection 28 59.16 Quite High
Rheumatoid Arthritis 3 52.52 Quite High
Aids-related Complex 3 48.64 Quite Low
Disease 14 36.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the biological importance of CPM expression on MAC in vivo is difficult to predict, since a wide range of biologically active peptides are substrates for CPM, and the relevance for most of those peptides to be processed by CPM during an immune reaction is only poorly understood at present.
Gene_expression (expression) of CPM in MAC
1) Confidence 0.65 Published 1998 Journal Immunol. Rev. Section Abstract Doc Link 9553769 Disease Relevance 0.33 Pain Relevance 0.15
Additional significant sources of CPM have been consultations with expert physicians, conferences and the literature.
Gene_expression (sources) of CPM associated with pain management
2) Confidence 0.52 Published 1991 Journal J Pain Symptom Manage Section Abstract Doc Link 2030297 Disease Relevance 0.31 Pain Relevance 0.75
A synchronous expression of CPM together with MAC cytotoxic function makes a functional relationship very well possible.
Gene_expression (expression) of CPM in MAC
3) Confidence 0.51 Published 1998 Journal Immunol. Rev. Section Abstract Doc Link 9553769 Disease Relevance 0.36 Pain Relevance 0.16
e. adherence to treatment protocols and use of CPM (in hours);
Gene_expression (use) of CPM
4) Confidence 0.50 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386789 Disease Relevance 0 Pain Relevance 0
Although we prestratified on preoperative active RoM (strata > 100° <), mean preoperative flexion RoM was slightly higher in the CPM group.
Gene_expression (group) of CPM
5) Confidence 0.50 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386789 Disease Relevance 0.05 Pain Relevance 0
It also suggested, however, that more research was required to assess the differences in CPM effectiveness with different characteristics of application, such as total duration of treatment and intensity of CPM interventions.
Gene_expression (effectiveness) of CPM
6) Confidence 0.50 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2386789 Disease Relevance 0 Pain Relevance 0
e. adherence to treatment protocols and use of CPM (in hours), measured with a patient diary;
Gene_expression (use) of CPM
7) Confidence 0.39 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1403777 Disease Relevance 0 Pain Relevance 0
M CPM compared with 100 ?
Gene_expression (compared) of CPM
8) Confidence 0.14 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1538584 Disease Relevance 0.18 Pain Relevance 0.14
We estimate that the soft coral extract contained ~7% CPM, which would give approximately 50 ?
Gene_expression (contained) of CPM
9) Confidence 0.14 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1538584 Disease Relevance 0.09 Pain Relevance 0.08
Thus, we suggest that Sinularia that is heavily encrusted and is highly packed with dense spicules does not produce CPM: while the fleshy flourishing Lobophyton and Sarcophyton samples produce defences that might include CPM for protection.
Neg (not) Gene_expression (produce) of CPM in spicules
10) Confidence 0.13 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1538584 Disease Relevance 0 Pain Relevance 0
However, all three species studied have symbiotic Zooxanthellae and the biosynthesis of CPM may reflect common ancestry.
Gene_expression (biosynthesis) of CPM
11) Confidence 0.13 Published 2006 Journal BMC Pharmacol Section Body Doc Link PMC1538584 Disease Relevance 0.05 Pain Relevance 0.03
In this study we found an 8 degrees difference in flexion ROM when using CPM in the in hospital phase after total knee arthroplasty.
Gene_expression (using) of CPM in knee
12) Confidence 0.08 Published 2006 Journal BMC Musculoskelet Disord Section Body Doc Link PMC1579215 Disease Relevance 0 Pain Relevance 0
Although the majority of patients with advanced cancer in this study expressed preferences for CPM, younger age, higher baseline PPSv2, and involvement of SDMs in the decision process were significantly associated with preferences for AAMM.



Gene_expression (expressed) of CPM associated with cancer
13) Confidence 0.05 Published 2010 Journal BMC Cancer Section Abstract Doc Link PMC2988029 Disease Relevance 0.26 Pain Relevance 0.15

General Comments

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