INT192152

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Context Info
Confidence 0.24
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.69
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp14) cytoplasm (Mmp14)
Anatomy Link Frequency
fibroblasts 2
Mmp14 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 340 100.00 Very High Very High Very High
rheumatoid arthritis 38 96.28 Very High Very High Very High
cytokine 14 85.52 High High
anesthesia 2 76.64 Quite High
Arthritis 5 34.72 Quite Low
Osteoarthritis 19 24.56 Low Low
Inflammation 10 5.00 Very Low Very Low Very Low
Neuropeptide 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 246 98.00 Very High Very High Very High
Rheumatoid Arthritis 38 96.28 Very High Very High Very High
Severe Combined Immunodeficiency 10 86.40 High High
Arthritis 6 34.72 Quite Low
Osteoarthritis 19 24.56 Low Low
Congenital Anomalies 1 17.88 Low Low
Disease 15 16.92 Low Low
Fibrosarcoma 2 10.80 Low Low
Skin Cancer 9 9.84 Low Low
INFLAMMATION 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, loss of MT1-MMP consistently decreased the invasion or growth promoting influence of fibroblasts in vivo and in vitro and loss of MMP-2 and MMP-9 altered tumor growth with increasing complexity of the model system.
Negative_regulation (loss) of MT1-MMP in fibroblasts associated with cancer and metalloproteinase
1) Confidence 0.24 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.87 Pain Relevance 0.93
Consistent with other reports that have identified the importance of MT1-MMP in remodeling of type I collagen matrices [8,14], we hypothesized that MT1-MMP deficient fibroblasts would be unable to invade type I collagen matrices.
Negative_regulation (deficient) of MT1-MMP in fibroblasts associated with metalloproteinase
2) Confidence 0.20 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.39 Pain Relevance 0.42
Because TIMP-3, for instance, both inhibits MT1-MMP (which can activate other MMPs) and inhibits the shedding of TNF-?
Negative_regulation (inhibits) of MT1-MMP associated with metalloproteinase
3) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2212555 Disease Relevance 0.43 Pain Relevance 0.38

General Comments

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