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Context Info
Confidence 0.19
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp14, Mmp2) cytoplasm (Mmp14, Mmp2) extracellular space (Mmp2)
extracellular region (Mmp2) proteinaceous extracellular matrix (Mmp2) plasma membrane (Mmp2)
Anatomy Link Frequency
fibroblasts 1
Mmp14 (Mus musculus)
Mmp2 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 203 100.00 Very High Very High Very High
cytokine 10 85.80 High High
chemokine 6 85.36 High High
Spinal cord 9 76.64 Quite High
Multiple sclerosis 3 40.80 Quite Low
Central nervous system 30 27.12 Quite Low
Inflammation 7 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
glial activation 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 124 99.60 Very High Very High Very High
Severe Combined Immunodeficiency 5 77.48 Quite High
Multiple Sclerosis 51 72.80 Quite High
Disease 6 71.12 Quite High
Malignant Neoplastic Disease 2 49.12 Quite Low
Bordatella Infection 3 23.20 Low Low
Targeted Disruption 17 18.24 Low Low
Injury 10 12.08 Low Low
Head & Neck Cancer 1 6.00 Low Low
INFLAMMATION 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because MT1-MMP is known to activate MMP-2, reduced tumor cell invasion and tumor growth demonstrated in coculture experiments with MT1-MMP null fibroblasts may in part result from a failure to activate pro-MMP-2.
MT1-MMP Positive_regulation (activate) of MMP-2 in fibroblasts associated with cancer and metalloproteinase
1) Confidence 0.19 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450297 Disease Relevance 0.85 Pain Relevance 0.99
In addition, MT-MMPs are known to cleave and activate secreted MMPs, which was first described for activation of MMP-2 by MMP-14 through interaction with tissue inhibitor of metalloproteinases-2 (TIMP-2) [15,16].
MMP-14 Positive_regulation (activation) of MMP-2 associated with metalloproteinase
2) Confidence 0.16 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2075488 Disease Relevance 0.38 Pain Relevance 0.82

General Comments

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