INT192164

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Context Info
Confidence 0.04
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.80
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BAK1, BCL2) endoplasmic reticulum (BAK1, BCL2) intracellular (BAK1, BCL2)
cytosol (BAK1, BCL2) cell morphogenesis (BCL2) aging (BAK1)
Anatomy Link Frequency
PC-3 1
BAK1 (Homo sapiens)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 42 61.92 Quite High
cytokine 1 47.12 Quite Low
antagonist 32 34.80 Quite Low
cINOD 4 31.52 Quite Low
Potency 1 15.40 Low Low
metalloproteinase 14 5.00 Very Low Very Low Very Low
qutenza 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 180 99.54 Very High Very High Very High
Bladder Cancer 11 85.24 High High
Cancer 182 81.32 Quite High
Metastasis 46 77.12 Quite High
Prostate Cancer 19 72.40 Quite High
Death 34 68.96 Quite High
Hyperplasia 5 68.96 Quite High
Reprotox - General 1 62 68.08 Quite High
Breast Cancer 32 62.40 Quite High
Carcinoma 9 57.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, TGZ-induced apoptosis in PC-3 cell lines was shown to involve reduced association of Bcl-2 and Bcl-xL with Bak, leading to caspase-dependent apoptosis [15].
Bak Binding (association) of Bcl-2 in PC-3 associated with apoptosis
1) Confidence 0.04 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450298 Disease Relevance 1.06 Pain Relevance 0.03
2-TG reduced the association of Bak with Bcl-2
Bak Binding (association) of Bcl-2
2) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.83 Pain Relevance 0
Antagonizing this reaction are the BH3-only proteins, which promote apoptosis by displacing Bax and Bak bound to the Bcl-2 proteins.
Bak Binding (bound) of Bcl-2 associated with apoptosis
3) Confidence 0.01 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2933845 Disease Relevance 0.91 Pain Relevance 0

General Comments

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