INT192165

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Context Info
Confidence 0.06
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.35
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BAK1, BCL2L1) intracellular (BAK1, BCL2L1) cytosol (BAK1, BCL2L1)
aging (BAK1) endoplasmic reticulum (BAK1) cytoplasm (BCL2L1)
Anatomy Link Frequency
PC-3 1
BAK1 (Homo sapiens)
BCL2L1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 14 61.92 Quite High
antagonist 10 34.80 Quite Low
cINOD 2 31.52 Quite Low
Potency 1 15.40 Low Low
Inflammation 9 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Hippocampus 7 5.00 Very Low Very Low Very Low
Eae 6 5.00 Very Low Very Low Very Low
long-term potentiation 5 5.00 Very Low Very Low Very Low
Kinase C 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 152 99.02 Very High Very High Very High
Bladder Cancer 10 85.24 High High
Cancer 16 78.24 Quite High
Prostate Cancer 19 72.40 Quite High
Breast Cancer 3 62.40 Quite High
Coronary Artery Disease 1 55.84 Quite High
Disease 128 50.00 Quite Low
Acidosis 1 47.52 Quite Low
Colon Cancer 1 39.04 Quite Low
Death 56 38.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, TGZ-induced apoptosis in PC-3 cell lines was shown to involve reduced association of Bcl-2 and Bcl-xL with Bak, leading to caspase-dependent apoptosis [15].
Bak Binding (association) of Bcl-xL in PC-3 associated with apoptosis
1) Confidence 0.06 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450298 Disease Relevance 1.06 Pain Relevance 0.03
In viable cells, Bcl-XL binds Bax and Bak, thus keeping them in an inactive form.
Bak Binding (binds) of Bcl-XL
2) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.28 Pain Relevance 0

General Comments

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