INT192167

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Context Info
Confidence 0.05
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.89
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (BAK1, BCL2) endoplasmic reticulum (BAK1, BCL2) intracellular (BAK1, BCL2)
cytosol (BAK1, BCL2) cell morphogenesis (BCL2) aging (BAK1)
Anatomy Link Frequency
PC-3 2
BAK1 (Homo sapiens)
BCL2 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 42 62.24 Quite High
antagonist 32 35.12 Quite Low
cINOD 4 31.52 Quite Low
Potency 1 15.72 Low Low
qutenza 3 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 159 99.18 Very High Very High Very High
Bladder Cancer 10 85.56 High High
Cancer 80 78.24 Quite High
Prostate Cancer 19 72.40 Quite High
Reprotox - General 1 4 68.08 Quite High
Breast Cancer 10 62.40 Quite High
Carcinoma 9 57.68 Quite High
Acidosis 1 47.52 Quite Low
Colon Cancer 12 39.04 Quite Low
Death 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, TGZ-induced apoptosis in PC-3 cell lines was shown to involve reduced association of Bcl-2 and Bcl-xL with Bak, leading to caspase-dependent apoptosis [15].
Negative_regulation (reduced) of Bak Binding (association) of Bcl-2 in PC-3 associated with apoptosis
1) Confidence 0.05 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1450298 Disease Relevance 1.06 Pain Relevance 0.03
2-TG reduced the association of Bak with Bcl-2
Negative_regulation (reduced) of Bak Binding (association) of Bcl-2
2) Confidence 0.02 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 0.83 Pain Relevance 0

General Comments

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