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Context Info
Confidence 0.03
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.19
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CASP3, ESR1) cytoplasm (CASP3, ESR1) nucleus (CASP3, ESR1)
plasma membrane (CASP3, ESR1) mitochondrion (CASP3) enzyme binding (ESR1)
CASP3 (Homo sapiens)
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 4 67.92 Quite High
Inflammation 1 5.00 Very Low Very Low Very Low
wide dynamic range 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Carcinoma 4 95.44 Very High Very High Very High
Cancer 107 92.28 High High
Breast Cancer 97 90.04 High High
INFLAMMATION 2 66.48 Quite High
Colon Cancer 3 61.36 Quite High
Apoptosis 5 47.12 Quite Low
Metastasis 13 43.04 Quite Low
Adhesions 1 9.60 Low Low
Disease 15 5.00 Very Low Very Low Very Low
Recurrence 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
BRCA1 could be characterized as having a basal phenotype, ER-negative and HER2-negative, with up-regulation of cyclin A and caspase 3, but downregulation of cyclin D1 and D3, CDKIs (p16, p21, p27), and BCL2, the opposite phenotype from most BRCA2 carcinomas.
caspase 3 Regulation (regulation) of ER associated with carcinoma
1) Confidence 0.03 Published 2006 Journal Proteome Sci Section Body Doc Link PMC1456950 Disease Relevance 1.19 Pain Relevance 0.19

General Comments

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