INT192225

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Context Info
Confidence 0.58
First Reported 2006
Last Reported 2011
Negated 3
Speculated 2
Reported most in Body
Documents 35
Total Number 40
Disease Relevance 32.82
Pain Relevance 6.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (HDAC9) transcription factor binding (HDAC9) cytoplasm (HDAC9)
Anatomy Link Frequency
spinal cord 4
pancreas 1
HDAC9 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 156 99.68 Very High Very High Very High
Osteoarthritis 252 99.64 Very High Very High Very High
Thermal hyperalgesia 56 99.58 Very High Very High Very High
rheumatoid arthritis 519 99.36 Very High Very High Very High
Inflammation 335 98.88 Very High Very High Very High
Hyperalgesia 68 97.84 Very High Very High Very High
Arthritis 42 96.20 Very High Very High Very High
IPN 20 94.52 High High
spinal dorsal horn 8 92.32 High High
chemokine 9 87.04 High High
Disease Link Frequency Relevance Heat
Myeloproliferative Disorder 92 100.00 Very High Very High Very High
Cancer 1108 99.96 Very High Very High Very High
Pancreatic Cancer 77 99.84 Very High Very High Very High
Stomach Cancer 73 99.84 Very High Very High Very High
Ovarian Cancer 36 99.72 Very High Very High Very High
Pulmonary Disease 33 99.72 Very High Very High Very High
Frailty 267 99.64 Very High Very High Very High
Hyperalgesia 124 99.58 Very High Very High Very High
Disease 389 99.54 Very High Very High Very High
Rheumatoid Arthritis 543 99.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the inhibition of class I HDAC with MS-275 showed no effect on CFA-induced thermal hyperalgesia and in addition the expression of this class of HDACs in the spinal cord was not induced by CFA.


Gene_expression (expression) of HDAC in spinal cord associated with thermal hyperalgesia and spinal cord
1) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 1.01 Pain Relevance 0.81
Comparison of the effects of HDACIs specific to class II and IIa as well as the expression pattern of different HDACs in the spinal cord in response to CFA suggests that the members of class IIa HDACs may be potential targets for attenuating persistent inflammatory pain.



Gene_expression (expression) of HDAC in spinal cord associated with ipn and spinal cord
2) Confidence 0.58 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2942827 Disease Relevance 0.66 Pain Relevance 0.76
In addition, analyses of expression of HDACs in the spinal cord following tissue damage caused by CFA revealed that the members in class IIa HDACs underwent upregulation.
Gene_expression (expression) of HDAC in spinal cord associated with spinal cord
3) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2942827 Disease Relevance 0.48 Pain Relevance 0.65
Several classes of histone deacetylases (HDACs) are expressed in the spinal cord that is a critical structure of the nociceptive pathway.
Gene_expression (expressed) of HDAC in spinal cord associated with nociception and spinal cord
4) Confidence 0.58 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2942827 Disease Relevance 0.59 Pain Relevance 0.52
Hydralazine and magnesium valproate produce DNA demethylation, HDAC inhibition, and gene reactivation in primary tumors.
Gene_expression (produce) of HDAC associated with cancer
5) Confidence 0.49 Published 2006 Journal PLoS ONE Section Abstract Doc Link PMC1762324 Disease Relevance 0.55 Pain Relevance 0
To provide insight into the biological behavior of pancreatic cancer and to identify new potential biomarkers, a study aiming to examine the levels of HDAC and SIRT gene expression in pancreatic cancer compared to normal pancreas tissue has been initiated.
Gene_expression (expression) of HDAC in pancreas associated with pancreatic cancer
6) Confidence 0.41 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 1.41 Pain Relevance 0.12
Taking into account that angiogenesis is required for tumor progression, it is reasonable to suggest that molecules that are able to interfere with HDAC expression/activity may be of particular therapeutic benefit.
Gene_expression (expression) of HDAC associated with cancer
7) Confidence 0.41 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 0.63 Pain Relevance 0
Due to the fact that almost 90% of the patients are unsuitable for resection, our own data are the first to demonstrate that HDAC gene expression, particularly HDAC7, could be a possible marker of PA [64].
Gene_expression (expression) of HDAC associated with adenocarcinoma
8) Confidence 0.41 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2964042 Disease Relevance 1.22 Pain Relevance 0.18
Here we investigated the expression profiles of class I and II HDACs (HDAC 1-8) in OA and RA synovial tissues, to identify the candidate HDAC gene in synovial inflammation in RA.
Spec (investigated) Gene_expression (expression) of HDAC associated with inflammation, rheumatoid arthritis and osteoarthritis
9) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.26 Pain Relevance 0.55
The HDAC activity was expressed as arbitrary fluorescence units.
Gene_expression (expressed) of HDAC
10) Confidence 0.38 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.13 Pain Relevance 0.06
In addition, it is also reported that the histone deacetylase (HDAC) inhibitors have a
Gene_expression (histone) of HDAC
11) Confidence 0.37 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408709 Disease Relevance 0.74 Pain Relevance 0.11
ITF2357 is a synthesized HDAC inhibitor containing a hydroxamic acid moiety linked to an aromatic ring.
Gene_expression (synthesized) of HDAC
12) Confidence 0.36 Published 2010 Journal J Hematol Oncol Section Body Doc Link PMC2827364 Disease Relevance 1.48 Pain Relevance 0.13
Total nuclear HDAC activity (expressed as micromolar values of the deacetylated HDAC substrate standard per 6 ?
Gene_expression (expressed) of HDAC
13) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.61 Pain Relevance 0.30
Measurement of HDAC activity
Gene_expression (activity) of HDAC
14) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0 Pain Relevance 0
We examined HAT and HDAC activities in the total nuclear extracts of synovial tissues from RA patients predominantly treated with conventional DMARDs, and their relationship with the cytoplasmic level of TNF?.
Spec (examined) Gene_expression (activities) of HDAC associated with rheumatoid arthritis
15) Confidence 0.33 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 1.30 Pain Relevance 0.58
The purpose of this study was to investigate the profile of histone deacetylase (HDAC) expression in the synovial tissue of rheumatoid arthritis (RA) compared with that of normal control and osteoarthritis (OA), and to examine whether there is a link between HDAC activity and synovial inflammation.


Gene_expression (expression) of HDAC associated with inflammation, rheumatoid arthritis and osteoarthritis
16) Confidence 0.29 Published 2010 Journal Arthritis Res Ther Section Abstract Doc Link PMC2945023 Disease Relevance 1.06 Pain Relevance 0.39
Array data showed that the expression of a number of histone deacetylase (HDAC) genes (HDAC3, 7A, 11) was suppressed by PAR2 activation, as were the related sirtuins 2, 3, 5 and 6 (Table 6).
Gene_expression (expression) of HDAC
17) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 0.05 Pain Relevance 0.13
significantly increased nuclear HDAC activity in RASFs (n = 3) and peaked at 6 h (P = 0.0001 vs 0 and 24 h) (Figure 5a), indicating that TNF?
Gene_expression (activity) of HDAC
18) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945023 Disease Relevance 0.70 Pain Relevance 0.35
The HDAC inhibitor romidepsin (FK228; depsipeptide) has also been
Gene_expression (depsipeptide) of HDAC inhibitor romidepsin
19) Confidence 0.26 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 1.09 Pain Relevance 0
The HDAC inhibitor romidepsin (FK228; depsipeptide) has also been
Gene_expression (The) of HDAC inhibitor romidepsin
20) Confidence 0.26 Published 2009 Journal Sarcoma Section Body Doc Link PMC2659882 Disease Relevance 1.09 Pain Relevance 0

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