INT192236

Context Info Confidence 0.24 First Reported 2006 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.59 Pain Relevance 0.08

unfolded protein binding (Hsp90aa1) protein folding (Hsp90aa1) cytosol (Hsp90aa1) ATPase activity (Hsp90aa1) intracellular (Hsp90aa1) response to stress (Hsp90aa1)

Anatomy Link Frequency artery endothelium 2 Hsp90aa1 (Mus musculus)

Pain Link Frequency Relevance Heat Inflammation 5 55.08 Pain 1 54.56 midbrain 8 49.12 Potency 1 41.72 Hippocampus 4 5.00 medulla 4 5.00 cytokine 3 5.00 cerebral cortex 2 5.00 ischemia 2 5.00 Thalamus 2 5.00

Disease Link Frequency Relevance Heat Cancer 6 99.04 Muscular Atrophy 1 80.16 Shock 15 69.12 Cataract 1 57.68 Mycobacterium Infection 1 56.96 INFLAMMATION 5 55.08 Vasculitis 2 53.52 Clinical Trials And Case Reports 1 50.00 Systemic Lupus Erythematosus 3 48.12 Acquired Immune Deficiency Syndrome Or Hiv Infection 3 47.80

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Hspabp, thought to be a tumor suppressor, is important for Hsp70 function by mediating its interaction with Hsp90 [86].

Positive_regulation (mediating) of Hsp90 Binding (interaction) of associated with cancer

1) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965669 Disease Relevance 0.36 Pain Relevance 0

NO is also instrumental in promoting Ang1-induced angiogenesis in combination with HSP90 and Akt in coronary artery endothelium [12].

Positive_regulation (induced) of HSP90 Binding (combination) of in artery endothelium

2) Confidence 0.05 Published 2006 Journal BMC Cell Biol Section Body Doc Link PMC1456963 Disease Relevance 0.23 Pain Relevance 0.08

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