INT192277
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
However, as variant NUT-rearrangements have been described [4], FISH techniques that detect both BRD4-NUT fusions and variant NUT-rearrangements should also be considered. | |||||||||||||||
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However, as variant NUT-rearrangements have been described [4], FISH techniques that detect both BRD4-NUT fusions and variant NUT-rearrangements should also be considered. | |||||||||||||||
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We herein describe, in detail, the laboratory methods by which the BRD4-NUT -rearrangement can be detected.
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BRD4 (bromodomain containing 4) is a bromodomain protein with an important role in cell cycle regulation inhibiting cell cycle progression from G1 to S, whereas NUT (nuclear protein in testis) is a protein of unknown function, normally only expressed in testis tissue [3]. | |||||||||||||||
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General Comments
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