INT192277

Context Info Confidence 0.44 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 4 Disease Relevance 2.07 Pain Relevance 0.04

nucleus (C15orf55) cytoplasm (C15orf55)

Anatomy Link Frequency testis 1 C15orf55 (Homo sapiens)

Pain Link Frequency Relevance Heat epidural 8 71.64 backache 4 39.60 vincristine 4 5.00 Spinal cord 4 5.00

Disease Link Frequency Relevance Heat Carcinoma 40 92.56 Cancer 76 91.24 Bone Cancer 4 80.84 Disease Progression 4 74.24 Sarcoma 12 72.96 Low Back Pain 4 39.60 Weight Loss 4 38.40 Hot Flashes 4 37.12 Superior Vena Cava Syndrome 16 18.00 Pressure And Volume Under Development 12 14.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, as variant NUT-rearrangements have been described [4], FISH techniques that detect both BRD4-NUT fusions and variant NUT-rearrangements should also be considered.

Gene_expression (detect) of NUT

1) Confidence 0.44 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1456975 Disease Relevance 0.55 Pain Relevance 0

However, as variant NUT-rearrangements have been described [4], FISH techniques that detect both BRD4-NUT fusions and variant NUT-rearrangements should also be considered.

Gene_expression (fusions) of NUT

2) Confidence 0.44 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1456975 Disease Relevance 0.54 Pain Relevance 0

We herein describe, in detail, the laboratory methods by which the BRD4-NUT -rearrangement can be detected.

Gene_expression (detected) of NUT

3) Confidence 0.39 Published 2006 Journal BMC Cancer Section Abstract Doc Link PMC1456975 Disease Relevance 0.59 Pain Relevance 0.04

BRD4 (bromodomain containing 4) is a bromodomain protein with an important role in cell cycle regulation inhibiting cell cycle progression from G1 to S, whereas NUT (nuclear protein in testis) is a protein of unknown function, normally only expressed in testis tissue [3].

Gene_expression (expressed) of NUT in testis

4) Confidence 0.34 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1456975 Disease Relevance 0.39 Pain Relevance 0

General Comments

This test has worked.